Sentences with phrase «of differentiation factors»

«In order to carry out the switch from self - renewal to differentiation, Bam must inactivate the functions of self - renewing factors as well as activate the functions of differentiation factors.»

Not exact matches

With the development of culture, differentiation within the different societies increased; hence the sociologist of religion has to take into account the temporal, regional, ethnic, cultural and social factors.

They make for differentiation within the practice, tradition, and organization of a religious community in certain periods, locally and otherwise, particularly if combined with the second factor.

Fetuses use vitamin D in the womb for many important processes including regulation of the metabolism of neurotropic factors and neurotoxins, signaling neuronal differentiation, and protecting the brain from inflammation.

Granulocyte colony - stimulating factors (G - CSFs) are commonly used as a supportive measure to boost the survival, proliferation and differentiation of neutrophils.

The research team, led by bioengineering professor Adam Engler, also found that a protein binding the stem cell to the hydrogel is not a factor in the differentiation of the stem cell as previously suggested.

After deciphering this natural differentiation process, the investigators duplicated it in the laboratory dish by adding a sequence of proteins, called growth factors, to the fluid bathing the stem cells.

Drosha degrades the messenger RNA for NFIB in the adult hippocampal stem cells and prevents the expression of this transcription factor which is necessary for the differentiation of oligodendrocytes and thus blocks their development and therefore biases differentiation towards neurons.

[Praveen R. Arany et al, Photoactivation of Endogenous Latent Transforming Growth Factor — β1 Directs Dental Stem Cell Differentiation for Regeneration] Could a light - based treatment for cavities and chipped teeth eventually be in the offing for people?

In 1991, Japanese researchers discovered that Lion's Mane contains two novel classes of nerve growth factor — molecules called hericenones and erinacines — that stimulate the differentiation and re-myelination of neurons.

The study revealed that growth factors — especially one known as growth differentiation factor 9 — coming from the eggs drove the feeding tube multiplication and growth process, acting directly upon the genetic machinery of the follicle cells surrounding the egg.

Now, two studies, one led by Fejzo, suggest that an excess of a blood - borne protein, growth differentiation factor 15 (GDF15), is a cause of HG, and perhaps other cases of nausea and vomiting in pregnancy.

Epidermal growth factor receptor (EGFR) signal transduction plays a major role in growth, proliferation and differentiation of mammalian cells.

These findings reveal molecular factors that can be used to evaluate the differentiation potential of different cell lines, which should expedite the progress of iPS cells to clinical use.

Another factor that could also contribute to the efficiency of iPS cell line differentiation is the method with which the iPS cells were made.

The study, performed in an animal model, was the first to identify growth differentiation factor 10, or GDF10, a molecule that previously had no known role in the adult brain, said Dr. S. Thomas Carmichael, the study's senior author and a professor and vice chair for research and programs in the UCLA department of neurology.

One of the key metabolic alterations that takes place during EMT is that of the epidermal growth factor receptor (EGFR) which is a pathway that regulates growth, survival, proliferation, and differentiation in mammalian cells.

miRNA - 335, a messenger nucleic acid, regulates the endodermal transcription factors Sox17 and Foxa2 and is essential for the differentiation of cells within this germ layer and their demarcation from the adjacent mesoderm.

These products, including the major malarial by - product hemozoin, malarial proteins and as yet undefined virulence factors, induce MyD88 - dependent inflammatory responses in osteoclast and osteoblast precursors, leading to increased RANKL expression (a key molecule inducing osteoclast differentiation), and over-stimulation of osteoclastogenesis favoring bone resorption.»

Studying mouse models of glaucoma, Ban, Apte and their colleagues identified a molecule in the eye called growth differentiation factor 15 (GDF15), noting that the levels of the molecule increased as the animals aged and developed optic nerve damage.

In addition, when these transcription factors lose their function, terminal differentiation into the vascular endothelium (completion of differentiation) is completely suppressed, and genes that are key to differentiation into vascular endothelial cells as well as transcription factors that maintain the undifferentiated state are adversely induced.

The differentiation of stem cells is largely controlled by external cues, including morphogenic growth factors, in the three - dimensional environment that surrounds the cells.

Previously, in the region that controls the function of the transcription factor that promotes differentiation from ES cells to a specific cell type, bivalent modifications of histones such as the accelerator and brake histone marks for transcription were thought to have coexisted.

Expanding from their previous studies with mice, the researchers first established that under specific conditions, culturing human embryonic stem cells with fibroblast growth factor 2 (FGF2) leads to neural differentiation particular to the midbrain / hindbrain region — the location of the cerebellum — within three weeks, and the expression of markers for the cerebellar plate neuroepithelium — the part of the developing nervous system specific for the cerebellum — within five.

In vitro, Pkn1 — / — Cgcs exhibited deregulated axonal outgrowth, elevated AKT phosphorylation, and higher levels of neuronal differentiation - 2 (NeuroD2), a transcription factor preventing presynaptic maturation.

A study of the development of the nervous system of the nematode Caenorhabditis elegans by Neda Masoudi, Oliver Hobert and colleagues reveals a novel function for a member of the basic helix - loop - helix family of transcription factors in controlling terminal neuron differentiation (rather than initial commitment to a neural fate).

OPC differentiation was selectively blocked by bHAf in a maturation - dependent fashion at the late OPC (preOL) stage by a noncanonical TLR4 / TRIF pathway that induced persistent activation of the FoxO3 transcription factor downstream of AKT.

The transcription factor Runx3 enhances the differentiation and survival of CD8 + resident memory T cells; enhancing Runx3 expression in responding T cells could lead to better therapies for infection and cancer.

FoxO3 constraint of OPC maturation was bHAf dependent, and involved interactions at the FoxO3 and MBP promoters with the chromatin remodeling factor Brg1 and the transcription factor Olig2, which regulate OPC differentiation.

«We found that IL - 34 is an essential growth factor for the differentiation of Langerhans cells and microglia during embryonic development,» says senior author Marco Colonna, MD, professor of medicine and of pathology and immunology.

We will develop mathematical models to predict the pathways of differentiation from naive to memory and effector T - cell subsets based on the characterisation of surface marker expression, transcription factors and cytokines production at early and late time points after immunisation.

Lohoff, M. & Mak, T. W. Roles of interferon - regulatory factors in T - helper - cell differentiation.

Interestingly, Ascl1 alone already induces neuronal properties, but co-expression of the other factors strongly promotes a degree of differentiation, as you can see here in the acquisition of more mature electrophysiological properties.

The team then asked this minimal model set to predict whether knockdown of a specific transcription factor would maintain the stem cell state or prompt differentiation.

The quickest, most efficient way to micromanage the cells» developmental decisions was to apply a simultaneous combination of factors that both encouraged the differentiation into one lineage while also actively blocking the cells from a different fate — a kind of «yes» and «no» strategy.

Our laboratory is interested in exploring the molecular mechanisms that drive the production of cancer stem cells and specifically in dissecting the microRNA / transcription factor circuitry that connects such differentiation metastability to tumour aggressiveness.

Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4.

We are investigating the roles of various transcription factors, kinases, and molecules involved in intracellular vesicular traffic in order to understand the differentiation of Vα14 iNKT cells.

Basic fibroblast growth factor reduces scar by inhibiting the differentiation of epidermal stem cells to myofibroblasts via the Notch1 / Jagged1 pathway.

Nuclear Factor Kappa B Signaling Initiates Early Differentiation of Neural Stem Cells.

Human stem / progenitor cells from bone marrow enhance glial differentiation of rat neural stem cells: a role for transforming growth factor β and Notch signaling.

Finally, I will show how we have combined our results to generate a model of hematopoietic differentiation where specific transcription factors control lineage regulatory regions; our model predicts many already known lineage - controlling factors as well as finds new potential regulators of hematopoietic differentiation such as ATF3 in monocytes and Tcf7l2 and Runx2 in NK cells.

What are the direct targets of key transcription factors that regulate cardiogenesis and cardiomyocyte differentiation and how do they function in networks?

In addition to p53, there are other transcriptional activatory mechanisms that are not well understood for the most part and which operate in response to mitogenic stimulation (11, 12), transforming growth factor - β (13, 14, 15), and aberrant oncogenic signals (16, 17) or during a number of cell differentiation processes (18, 19).

Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin - like growth factors.

However, genome integrating viral vectors and oncogenic transcription factors are still key parts of many reprogramming schemes, and many early differentiation studies need to be confirmed using iPSCs generated using safer non-integrating viral vectors.

One is the molecular identification of cell growth and differentiation factors, and their receptors that mimic embryonic developmental cues, and allow PSCs to differentiate into almost any mammalian cell type.

(B) One proposed model for bristle versus spikelet differentiation in a wild - type S. viridis inflorescence depends on a diffusible factor that enhances spatiotemporal accumulation of BRs.

We have identified a number of key transcription factors that are deregulated during this process, and we are using this information to investigate mechanisms by which differentiation can be reprogrammed in tumour cells.

The contribution of apoptosis - inducing factor (AIF) to villous trophoblast differentiation.