Given the critical
shortage of donor organs to replace those damaged by accident or disease, it has long been a goal of science to create human organs from stem cells.
Despite concerted efforts to increase the
supply of donor organs, waiting lists are still lengthy in many places.
She adds that recipients could have a greater
choice of donor organs, improving their chances of a good match.
Having a clone would be more like having a baby — though you might be able to talk it
out of a donor organ or two when he or she is older.
But, what if instead of being discarded, these organs could be «recycled» to help solve the critical
shortage of donor organs?
This Centre develops and commercializes novel methods that enhance the usable
pool of donor organs that can be safely transplanted.
With the shortage
of donor organs becoming an increasingly acute crisis, Atala has been able to grow and transplant skin, cartilage, muscle, bladders, vaginal organs, kidney cells and more, engineered using patients» own tissue and organs.
Warm liver preservation could also open the door to further
treatment of donor organs, says Jedediah Lewis, chief executive of the Organ Preservation Alliance, a non-profit organization in Berkeley, California.
The recipe for these replacement organs begins with destruction: Wash away the
cells of a donor organ with detergent, leaving behind just its spongy, protein support structure.
Modified preservation techniques to minimize organ injury related to energy metabolism may improve the
quality of donor organs after circulatory death.
The results had been awaited eagerly, because pigs» physiological resemblance to humans makes them a potential
source of donor organs.
Three dimensional organoid production has been one of the «hot topics» in regenerative medicine of the past year, and this strategy is making some headway into solving the
problem of donor organ shortages.
Researchers suggest that this liver tissue could be used in
place of donor organs during liver transplantation or during the bridge period until a suitable donor is available for patients with acute liver failure.
He also instituted an intestinal transplant program at Cleveland Clinic, spearheaded the use of new minimally invasive surgical techniques and introduced procedures to improve
preservation of donor organs.
If we can demonstrate that it's possible to eradicate HCV from patients who contract the virus from a transplant, this approach could open up access to an entirely new
pool of donor organs that are currently being discarded.
«Islet transplants have been used to successfully treat patients with unstable, high - risk type 1 diabetes, but the procedure has limitations, including a very limited
supply of donor organs and challenges in obtaining reliable and consistent islet preparations,» said trial investigator James Shapiro, MD, PhD, FRCSC, Director of the Clinical Islet Transplant Program, University of Alberta.
In Western society the population is growing older, the incidence of chronic disabilities which could be treated by stem cell therapy is steadily rising, and the
availability of donor organs is not matching the need.
Scientists in Japan said Wednesday they had grown human liver tissue from stem cells in a first that holds promise for alleviating the critical
shortage of donor organs.
With a shortage
of donor organs, Mayo Clinic is exploring therapeutic strategies for patients with debilitating liver diseases.
The operation is not technically difficult, but there is a shortage
of donor organs and the bowel is hard to protect from rejection and infection.