Sentences with phrase «of drug resistance»

These findings provide a rich resource for researchers investigating the molecular mechanism of drug resistance.

An analogy between the evolution of drug resistance in bacterial communities and malignant tissues.

This work suggests a new direction of study that would allow researchers to capitalize on the natural competition between pathogens to control the emergence of drug resistance.

Current treatments require active viral replication and target late stages of infection, which has led to the development of drug resistance.

This treatment strategy has substantially reduced but, importantly, not eliminated, the evolution of drug resistance within patients.

«For years, researchers have focused on delivering more chemotherapy drugs into cancer cells using nanoparticles, without targeting the root of drug resistance,» He said.

Your local veterinarian will also make that decision based on which parasites are most common in your area and the degree of drug resistance that those parasites have attained.

The goals of this five - year grant are to better understand how drug resistance spreads in a population and to identify the genetic basis of drug resistance.

There's been an unexpected development in our understanding of drug resistance in bacteria.

And past research has shown a threshold at which treating more cases leads to a higher incidence of drug resistance, making the disease difficult to treat and contain.

But when three different drugs aim at three different targets, as in combination drug therapy, the probability of drug resistance is much smaller.

The new treatments have been specifically developed to reduce the chance of drug resistance evolving in the parasite population.

In addition, these data suggest that bacteria that survive within host cells contribute significantly to infectious disease pathology, and should be considered a potential source of drug resistance.

This opens immense potential to shorten the sample - to - results time and is likely to lead to enormous benefits in rapid diagnosis of bacterial infection and identification of drug resistance.

The study found several genes that are associated with resistance to antibiotics, including new genes that might point to previously unknown mechanisms of drug resistance.

The approach could also prevent the development of drug resistance.

For the past decade, Gerry Wright has been trying to understand the rise of drug resistance by combing through the world's richest natural source of resistance - enabling DNA: a clod of dirt.

Dantas and his colleagues continue to study factors that affect the spread of drug resistance in bacterial communities in hospitals, the environment and the human digestive tract.

Tumors were evaluated for changes in volume and the expression of the drug resistance genes MDR1 and NANOG.

The expression of the tumoral multidrug resistance gene (MDR1), which encodes P - glycoprotein, and NANOG, a stem - cell marker and a regulator of the expression of drug resistance genes, was determined using qRT - PCR.

Not only should pets NOT be given unnecessary medications, but the rapidly developing issue of drug resistance should make us even more reluctant to over-use heartworm preventatives.

When they periodically analyzed the levels of drug resistance in the colony, they saw something unexpected: although the entire population was thriving in the presence of the drug, only a few individual bacteria were actually resistant.

Three decades later, Prichard's laboratory is conducting vanguard research in understanding the genetics of drug resistance in parasitic nematodes, which infect more than 350 million people in dozens of developing countries.

A test that can distinguish between bacterial and viral infections could prevent unnecessary use of antibiotics that speeds the rise of drug resistance

Just five out of hundreds of S. aureus strains are responsible for 70 % of drug resistance cases, a study finds.

Instead, many people end up with less expensive but ineffective drugs such as chloroquine and artemisinin monotherapies, which increase the risk of drug resistance.

The most common cause of drug resistance is the development of a second EGFR mutation known as T790 - M.

We find evolution has shifted from multiple origins of drug resistance («soft sweeps») to single origins («hard sweeps») as treatments have improved.

[6, 20, 57, 58] The study presented herein illustrates the role of GHRH signaling in the regulation of drug resistance in TNBC.

«Seeing a common theme of drug resistance in this well - characterised worm is extremely important because both people and animals are reliant on so few treatments against parasitic worms.»

«Although initial remission rates are high with available treatments, the disease comes back because of drug resistance that leads to relapse.

Detection technique may pave the way for a more tailored treatment that delays the onset of drug resistance

«Our paper demonstrates in a laboratory model how cancer can evade this class of therapy, and it provides insights into how clinical trials for these therapies could be further developed to overcome the problem of drug resistance,» he adds.

Globalization, changing climate, and the threat of drug resistance have conspired to set the stage for that perfect microbial storm: a situation in which an emerging pathogen — another HIV or smallpox, perhaps — might burst on the scene and kill millions before we can respond.

«We always hear about the discussions of drug resistance.

The researchers previously emphasized that pretreatment of cancer cells with epigenetic drugs in addition to standard chemotherapy may sensitize these cells to other cytotoxic (anti-cancer) drugs, especially important in the setting of drug resistance.

The strategy was containment: Build a firewall around areas of drug resistance by ramping up control measures, such as bednets, rapid diagnostic tests, and ACTs.

The drug also confers a high barrier to developing the complication of drug resistance.

His current specific interest is the elucidation of novel mechanisms of drug resistance through the discovery / identification of novel gene function (s) and phenotypes using RNAi - mediated gene silencing or cDNA overexpression.

This special issue of Science focuses on diverse areas where public health can be improved by making better use of the resources we have in our grasp, ranging from tailoring engineering projects to meet the needs of material - and infrastructure - limited regions, to building a surveillance network for the detection of drug resistance, to empowering women.

«New, noncommittal mechanism of drug resistance discovered.»

Now a new study has shown that microorganisms can use a temporary silencing of drug targets — known as epimutations — to gain the benefits of drug resistance without the commitment.

However, questions remain about how hard sweeps of drug resistance can occur at all under combination therapy.

In answer to the first question, we analyze how the mode of drug resistance evolution changed within patients throughout the epidemic using historical HIV sequences.

The rate of drug resistance evolution has plummeted in response.

«Signs of drug resistance can be identified which can help doctors and patients make informed decisions about treatment,» Cebon says.

«Both the increase in cell envelope thickness and in the outer membrane vesicles may be indicative of drug resistance mechanisms being activated in the spaceflight samples,» Zea said.

Survivin is also a major determinant of drug resistance in cancer, and a viable target for novel cancer therapeutics.