Treating a drug side effect with another drug can start a vicious cycle
of drug side effects and interactions that can land you in the hospital or even kill you.
Scientists Miquel Duran (left) and Patrick Aloy studied the molecular mechanisms
of drug side effects.
In fact, the genetic underpinnings
of drug side effects, in general, are not well understood.
Not exact matches
These risks and uncertainties include, among others: the unfavorable outcome
of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any
of our products or products using our proprietary technologies, which may lead to competition from generic
drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components
of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence
of efficacy and adequacy
of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results
of our clinical development activities may not be positive, or predictive
of real - world results or
of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights
of third parties, or have unintended
side effects, adverse reactions or incidents
of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.
On this
side of the 49th parallel, the cash problem isn't so much tax evasion and
drug dealing as counterfeiting.
After Italy, Pessina set his sights on France, where, with Barra at his
side, he rolled up 30 %
of the
drug - wholesaling market within five years and then moved into other countries.
Canada's generic
drug king found himself on the wrong
side of several shaking fingers in the past year.
Companies like U.S. biotech giant Gilead and the U.K.'s GlaxoSmithKline (the majority stakeholder in global HIV partnership ViiV Healthcare) have developed
drugs that drastically lower the chance
of HIV infection — or which simply lower the number
of drugs you have to take to treat it, consequently curbing the risk
of toxic
side effects while simplifying medical regimens.
The new offering, «Watson for Patient Safety,» will gobble up anonymized medical records, claims data, and millions
of electronic submissions to the FDA about potential
drug side effects (known as individual case safety reports) to see if it can learn about the hidden dangers
of medicines before they become too costly.
In addition to partnering with Celgene (celg) to better track negative
drug side effects, IBM (ibm) is applying its cognitive computing AI technology to recommend cancer treatment in rural areas in the U.S., India, and China, where there is a dearth
of oncologists, said Deborah DiSanzo, general manager for IBM Watson Health.
Agios Pharmaceuticals shares plunged more than 18 percent after the company discontinued development
of an experimental
drug for rare blood disorder due to
side effects seen in a study.
The
side effect was first observed earlier this month at the American Society
of Hematology conference, where CEODavid Schenkein spoke with CNBC about the safety
of one
of the molecules in its
drug, which was meant to treat pyruvate kinase deficiency, a rare, genetic anemia.
A more leftist system
of greater
drug price regulation could come with other negative
side - effects, Miller continued.
Typically, the group consists
of a «tie - down team» who escort the prisoner from his cell to the death chamber and then strap him to the gurney; medically trained personnel who set the intravenous lines; and those, like Bracey and Baxley, who sit on the other
side of a glass wall and press the buttons to inject the lethal
drugs into the prisoner once the team leader gives the order.
She said that employers» increased use
of high - deductible plans, one
of the
side - effects
of the law, has resulted in patients paying more out
of pocket for the
drug, and that's «where you're seeing a lot
of noise around EpiPen.»
The flip
side of that, though, is that an increase in demand for prescriptions will only intensify government efforts to keep
drug costs down.
Our Government is also committed to ensuring that
drug labels are written in plain language, and that the potential
side effects
of medication are accurately indicated.
Even as his counterparts like Atlanta rapper Killer Mike — who has been very vocal about America's racist war on
drugs and his own political beliefs — used their celebrity for fundraising, meetings with politicians, and self - penned articles; the rapper usually left politics to the
side as he expanded his business and rose to the top
of the corporate ladder.
«There's no other injectable
drug that works like that,» Lewin said
of Isuprel, and other
drugs may have unwanted
side effects, he said.
These healthcare brands will have the effect
of soothing out the inevitable fluctuations that occur on the pharmaceutical
side, though right now, Glaxo's portfolio is boasting robust growth from small - scale HIV
drugs Triumeq and Trivicay (which, as the CEO noted in the last annual report, sport year - over-year sales growth
of 41 % and 43 %, respectively).
Doctors often use a combination
of off - label
drugs to try to manage patients» nightmares, flashbacks and depression, but the
drugs do nothing to treat the underlying condition, and can have negative
side effects.
Martin Shkreli, the founder and chief executive
of Turing, said that the
drug is so rarely used that the impact on the health system would be minuscule and that Turing would use the money it earns to develop better treatments for toxoplasmosis, with fewer
side effects.
To combat the activities
of Mexican, Central American, and South American transnational criminal organizations — including illicit finance and money laundering activities and the flow
of illegal
drugs — the FBI works
side - by -
side with its numerous domestic and international partners to infiltrate, disrupt, and dismantle these groups by targeting their leadership and using sensitive investigative and intelligence techniques in long - term, proactive investigations.
Luxury condo conversion
of drug rehab center in NYC's Upper West
Side priced for $ 61 million sellout
But Amsterdam, second only to Bruges for canal -
side prettiness, to Vancouver for
drugs and hookers, and to nowhere for massive mobs
of selfie - snapping sightseers, still hosts companies offering workshop tours.
The existing
drugs for osteoarthritis cause a high frequency
of stomach ulcers and other
side effects such as high blood pressure.
If there is a competitive
drug market, with limited advantage offered by the new
drug in terms
of increased effectiveness or reduced
side effects, the
drug will probably not win substantial market share in its product category.
As the Astra Zeneca Pfizer deal gets more bad tempered and political, what are the
side effects
of this massive
drug firm deal?
ALKS 3831 is a treatment for schizophrenia that avoids the
side effects
of weight gain and metabolic problems that the incumbent
drug has, and a phase 3 trial for it should read out in the fall
of 2018.
It tells the story
of «the guinea pigs»» the people most likely to be research subjects in Phase I trials, which test the safety
of a
drug under development by giving it to healthy subjects and examining any
side effects they experience.
The
drug has an unfortunate
side effect
of tricking the immune system into attacking healthy cells, but the relative damage was insignificant compared to what cancer would have done to them.
She suggests, convincingly, that much
of this was due to mercury poisoning, a
side - effect
of the terrifying array
of Victorian
drugs and potions Faber was prescribed by his doctors.
Many would argue that it's possible for her to feel better without taking
drugs: she could try the «talking cure» (regular sessions with a counselor), or an alternative treatment such as herbal or light therapy If she goes to an M.D., though, she'll likely carry my a prescription for an antidepressant such as Prozac or Zoloft — one
of these brave new medicines that promise such good results with so few
side effects,
• PLIVA vs. Mensing: Ruled that makers
of generic
drugs can not be sued for failing to warn patients
of new dangers or
side effects.
Many laboratory tests were performed and chemotherapy — requiring intravenous punctures — was resumed, even though studies had shown that this type
of cancer does not respond significantly, if at all, to
drug treatment, and even though complications and
side effects from the
drugs were expected.
Even if we can not know the answer to all
of society's ills, even if we can not pretend to know how to solve the problems
of crime and
drugs and inflation and poverty, we can still proclaim that it is obviously and unquestionably a moral wrong to maintain a penal system based on vengeance instead
of rehabilitation; to allow human rights violations to go unchallenged (on either
side of the iron curtain); to waste vast quantities
of food and resources while others are malnourished and sick and poor; or to allow so many children in our own midst to go through childhood unwanted and unloved and even abused.
The conclusion: given relatively unlimited availability, heroin users will voluntarily stabilize or reduce their dosage and some will even choose abstinence; long - addicted users can lead relatively normal, stable lives if provided legal access to their
drug of choice, and with few
side effects; and ordinary citizens (in Switzerland at least) will support such initiatives.
With all the commercialization
of drugs, promoting made up diseases and disorders, these companies are already brainwashing this country that everyone is sick and if you take there littel pill you can» sleep better, get rid
of skin disorders, etc.» The
side effects are worse than the dsupposed disorder to begin with.
«In upcoming episodes we will be showing the very negative
side of drug taking as Billy's life starts to fall apart.»
When inflammation strikes, we are conditioned into reaching for a quick fix in the way
of pharmaceutical or prescribed
drugs such as aspirin and ibuprofen, temporary panacea's that come with their own adverse
side effects and with long term use have the potential to create a host
of health problems independently.
Capsaicin can stimulate the body without the
side effects
of synthetic
drugs.
After suffering from the terrible
side effects
of steroids, antibiotics, and immunosuppressant
drug therapy, I decided to do some research
of my own and I soon discovered that my symptoms could be controlled simply by the food I put in my body.
Aside from tuna I have not had much desire to eat canned meat so I thought this stuff must be some kind
of magic to risk having to deal with
drug - sniffing dogs just to eat it on the other
side of the border.
As someone who attended Villanova on an athletic scholarship and who also had the opportunity to be a resident assistant responsible for overseeing one
of the male dorms, I have been exposed to both
sides of the
drug issue.
This was before Mackey had won a single Iditarod, let alone four straight; before he used what he calls his marathon style — catnapping as his sled moves and covering 100 - mile chunks at a moderate pace without prolonged rest, instead
of sprinting from rest stop to rest stop like most other racers — to win an unprecedented double (the Yukon Quest, the world's other 1,000 - mile dogsled race, and just weeks later the Iditarod) not once but twice; before he became so dominant that slower competitors complained they had no chance to finish within five days
of him (the requirement for an official place and a commemorative belt buckle); and before a rival pushed for
drug testing at the 2010 Iditarod, suspecting that Mackey's secret was his prescription for medical marijuana to alleviate the
side effects
of cancer treatment.
Zagreb midfielder Arijan Ademi failed a
drug test in the wake
of his
side's shock 2 - 1 win in their opening Champions League fixture against the Gunners on September 16.
«That would depend on a lot
of things, including the
side effects
of the
drugs,» says Dr. Barry Starr, a geneticist at Stanford University's Tech Museum
of Innovation and who runs its «Ask a Geneticist» column.
Her
side of the issue is understandable and My
side of the issue is understandable but it leaves a rift in our relationship that cant be filled by money or
drugs, ive tried... im still trying.
Babies have also been known to fall heavily asleep during or after breastfeeding, reacting to the sedating
side effects
of the
drug.
«No one explained that one
of the
side effects
of this
drug was dehydration, which significantly interferes with milk production,» she says.