Sentences with phrase «of durable remission»

Not exact matches

Better understanding of how immune tolerance is lost and regained could inform efforts toward establishing stronger and more durable phases of remission in autoimmune disease and toward preventing cancer recurrence.

Of the 42 patients receiving the higher dosage, 36 percent experienced durable reponses, including two who had complete remissions and two more whose remissions also were high quality (known as very good partial responses).

Updated results from a global clinical trial of the CAR T - cell therapy for ALL reveal that children and young adults continued to show high rates of durable, complete remission.

Priority will be given to studies that evaluate combinations of agents that induce immune deviation and / or regulation, produce effector cell depletion or exhaustion, to achieve durable clinical remission of disease.

The cytokines interleukin - 2 (IL - 2) and interferon - alpha cause kidney cancers to shrink in approximately 10 % -20 % of patients, and provide durable remissions in a subset of these patients.

The other 5 vaccinated dogs that relapsed received single - agent prednisone as salvage therapy, one of which achieved a durable second remission and did not relapse.

Fifteen of 19 (79 %) vaccinated dogs in Group 2 eventually relapsed, but 4 dogs (21 %) did not and achieved a durable (> 16 months) first remission after chemotherapy and CD40 - B vaccination.

Three of these four vaccinated dogs with a chemotherapy - induced durable second remission are still alive with no evidence of lymphoma at 689, 1209, and 1216 days after the start of their initial chemotherapy.

Ten of the vaccinated dogs (52.6 %) have died due to lymphoma; six remain alive in durable first or second remission, and 3 were euthanized due to other causes.

In the unvaccinated Group 3, 39 of 46 dogs (84 %) that relapsed were treated with salvage chemotherapy and one dog received prednisone alone; however, only 3 (7.7 %) of the dogs in Group 3 that received salvage therapy achieved a durable second remission, compared to 40 % of vaccinated dogs that achieved a durable second remission to salvage therapy, a difference that was statistically significant (p = 0.025).

Ten of the 15 vaccinated dogs (66.7 %) in Group 2 that relapsed were treated with cyclophosphamide, vincristine, and prednisone (COP) as salvage therapy and four of these dogs (40 %) achieved durable second clinical remission (> 22 months) and did not relapse.