«Detection of ctDNA allows identification of a subgroup of patients at high risk
of early relapse and inferior survival, allowing stratification of patients to adjuvant regimens associated with higher toxicity but greater potential for efficacy.»
Not exact matches
Early models
of addiction viewed successful treatment and
relapse as «all - or - nothing.»
He burst back to form in the last few games
of last season and came back
early from the summer break to make sure he was in top shape for the beginning
of the new campaign, only to be cruelly struck with a
relapse just before the Community Shield against Chelsea.
One
of those
early patients was a young girl named Emily Whitehead who arrived in June's clinic, «on death's door,» with an aggressive form
of relapsed childhood leukemia.
The company is also working on a similar test in solid tumors for
early diagnosis
of relapse, and is developing tests that will help diagnose some lymphomas that are notoriously tricky to detect.
Several months
earlier, a course
of 10 shock treatments over a three - week period had stopped her severe depression in its tracks; she was now in for a «maintenance» session to prevent a
relapse.
The study experienced very rapid enrollment and at the preplanned independent data and safety monitoring review panel, the study was stopped
early only 10 months after the study commenced because it met the primary endpoint
of improving progression - free survival (time to cancer
relapse).
«The recent discovery
of tumor - promoting milieus, referred to as metastatic niches, that are established at distant sites prior to or upon the arrival
of disseminated tumor cells could explain cancer cells that
relapse early, but in late
relapsing populations, what tumor cells do from the time
of dissemination to the time they become clinically detectable has been a big question.»
The cause
of early metastatic
relapse in breast cancer has long been debated, with many ascribing these
relapses to the natural progression
of the disease.
Such uncertainty hinders the development and application
of therapeutic approaches that could potentially reduce
early metastatic
relapse.
«Further studies will show whether the prevention
of these
early brain responses is associated with reduced rates
of craving and
relapse in cocaine - dependent patients,» added Childress.
«While each
of these genes was independently associated with metastatic prostate cancer, they have never been studied together in the context
of early detection
of patients with prostate cancer that will
relapse after localized therapy with curative intent, «according to the authors, led by Leigh Ellis, PhD, in the Dana - Farber Department
of Oncologic Pathology.
In this
early work they found they could see whether a patient was
relapsing by tracking levels
of circulating tumour DNA.
«Blood test may give
early warning
of skin cancer
relapse.»
Collaboration with Hematology and Bone Marrow Transplantation Unit research group in molecular diagnostics applied to the management
of patients undergoing allogeneic SCT, especially for the detection
of minimal residual disease and
early relapse.
Residual leukemic cells that remain in the bone marrow following treatment are a major cause
of disease
relapse and can also act as an
early indicator to the effectiveness
of a given treatment strategy.
Notes for editors Research: Contribution
of dietary intake to
relapse rate in
early paediatric multiple sclerosis doi 10.1136 / jnnp -2017-315936 Editorial: Diet and disease modification in multiple sclerosis: a nutritional epidemiology perspective doi 10.1136 / jnnp -2017-316375
Our team was the first to report that a single CTC detected in the blood
of early breast cancer patients was associated with a higher risk
of metastatic
relapse (Pierga, Clin Cancer Res 2008).
Guided / recorded awareness exercises directed at increasing nonjudgmental awareness
of bodily sensations, feelings and thoughts Taking on problems with a position
of self - compassion Establishing an «action plan» made up
of strategies for dealing with
early warning signs
of relapse / recurrence.
• Administer products for appropriate duration
of therapy o Discontinuing treatment
early can lead to ineffective treatment or disease
relapse.
This group
of diseases cause recurrent or
relapsing ear disease beginning in
early life, often between the ages
of 6 months and 3 years.
The paper describes a randomized controlled trial
of targeting cognitive behavioural therapy (CBT) during prodromal or
early signs
of relapse in schizophrenia.
Early identification
of changes in behaviour is important in preventing
relapse of the condition.
A review
of that evidence
earlier this year led researchers at the University
of St. George's London to conclude that oxytocin may hold the key to treating opiate addiction and fending off
relapse.
The authors remind us that the potential for unremitting affective illness justifies the initiation
of early, extended, and exhaustive clinical intervention, with regular follow up sessions to prevent
relapse.
Analysis showed that 15 %
of the graduate group experienced a
relapse during follow - up, compared to 50 %
of early drop - outs and 61 %
of late dropouts.
In the latter stages
of the course patients develop an «action plan» that sets out strategies for responding when they become aware
of early warning signs
of relapse / recurrence.
The intervention group received usual care plus 5 sessions
of cognitive behavioural therapy during the first 12 weeks and further targeted cognitive behavioural therapy (2 to 3 sessions per week) if
early signs
of relapse were present (e.g. racing thoughts, suspiciousness; assessed by fortnightly questionnaires or by the treatment team).
The different psychosocial interventions all have some overlapping paradigms; for example, psychoeducation is part
of CBT.47 It may also reflect a similar approach to delivery, in that material is presented in a sequential and structured manner, with an emphasis on patients gaining personalised skills in the management
of their illness.34 Finally, the different psychological approaches each have their own emphasis, but share the strategies shown in Box 2 — that is, key content related to the therapeutic alliance, education, enhancement
of adherence,
early identification
of prodromes, awareness
of illness triggers, the importance
of supportive relationships, and development
of strategies such as
relapse prevention plans and constructive coping skills.
Relapse Prevention: Includes administering the functional analysis for relapse, discussing the behavioral chain of events, and describing and setting up an early warning
Relapse Prevention: Includes administering the functional analysis for
relapse, discussing the behavioral chain of events, and describing and setting up an early warning
relapse, discussing the behavioral chain
of events, and describing and setting up an
early warning system