Sentences with phrase «of early stage disease»

Not exact matches

Darzalex, however, has not yet reached its peak potential as the drug moves into earlier stages of the disease and is being tested on solid tumours like lung cancer.

Furthermore, an early - stage study pumping up the dose of its hemophilia A treatment — which aims to be a one - time therapy for the rare blood clotting - related disease — appeared to hit its targets without serious side effects.

Years ago, when Mass Design was in the early stages of planning and designing Butaro Hospital in the Burera District of Rwanda, it faced a serious design challenge: To reduce the transmission of airborne diseases like TB.

Our goal is to complement the current strategic interest of Chiesi Farmaceutici in the space of rare diseases by investing in early stage opportunities and accelerate the expansion of the Chiesi network in the US among universities, venture capital investors, rare disease patient organizations and start - ups developing treatments for rare diseases.

BioNTech hit the headlines in July when its experimental personalized cancer vaccine, tailored to the tumors of individual patients, kept disease in check in an early - stage clinical trial.

Although Anavex Life Sciences» Alzheimer's disease program should offer up plenty of data to digest this year, its research program is very early stage, and the company's balance sheet is worrisome enough for me to avoid it until placebo - controlled trial results are available.

A married retired man who finds his wife sexually unattractive tracks down a college girlfriend, a widow in the early stages of Alzheimer's disease, and the two begin a passionate affair.

Gyan, who enjoyed a successful stint at the Stadium of Light but is best known for his exploits at the 2010 World Cup, was set to lead his team out for the crucial group stage clash, but is likely to sit this one despite having been released from hospital after just one night because the disease was caught so early.

«I'm sorry, but f**k cancer,» Kerr said in France after winning the contest staged in memory of LET player Cassandra Kirkland, who died earlier this year at age 32 from lung cancer, and just days after former LPGA Tour golfer Kelli Kuehne's mother passed away from the disease.

[210] By then Wilson was the last surviving member of Attlee's cabinet, [211] and the unveiling of the statue would be one of the last public appearances by Wilson, who was by that point, in the early stages of Alzheimer's Disease and died at the age of 79 in May 1995.

Comparing a new patient's information with millions of other cases, Patient Rescue might be able to predict that they are in the early stages of a disease that has not yet become symptomatic, for example.

24 Love and Other Drugs, a film by Edward Zwick, director of the 2006 film Blood Diamond, depicts an artist named Maggie (Anne Hathaway) in the early stages of Parkinson's disease.

«This is a big step forward for early - stage detection of arthritis that will help start treatment early and prevent painful and debilitating disease.»

The research, «Protein oxidation, nitration and glycation biomarkers for early - stage diagnosis of osteoarthritis of the knee and typing and progression of arthritic disease,» is published by Arthritis Research and Therapy.

The combination of changes in oxidised, nitrated and sugar - modified amino acids in blood enabled early stage detection and classification of arthritis — osteoarthritis, rheumatoid arthritis or other self - resolving inflammatory joint disease.

Patients with early - stage and advanced OA, RA or other inflammatory joint disease were recruited for the study alongside a control group of those with good skeletal health, with plasma and synovial fluid samples from both groups being analysed using mass spectrometry.

Studies on the origins of BSE — a fatal disease marked in the early stages by loss of balance — gained urgency with the 1996 emergence in humans of the BSE - like new variant Creutzfeldt - Jakob disease (nvCJD).

In her opinion, it remains essential to screen aggressively for breast cancer in hopes of catching the disease in an early, treatable stage.

«Ultrasound enables you to screen a larger population, and that in turn means that life - threatening cardiovascular diseases can be detected at an earlier stage,» says Magnus Cinthio, senior lecturer in biomedical engineering and one of the researchers leading the work.

«Unfortunately, the current standard laboratory test is often unable to detect Lyme disease at an early stage of the infection,» explains Hannes Stockinger, Head of the Institute for Hygiene and Applied Immunology of the Center for Pathophysiology, Infectionology and Immunology of MedUni Vienna.

However, even for an expert, it can be difficult to tell how severe the disease is from the sketches alone, especially at the early stages of the disease.

Electrophysiological testing to measure peripheral nerve conduction properties is not a viable alternative because current methods lack the sensitivity required to detect damage to small, unmyelinated fibers, especially in early stages of disease.

As rates of skin cancer, or melanoma, rise for men and women in the United States, health experts are debating the effectiveness of annual total body examinations in helping to detect the disease in its earlier stages.

The trial has also included 10 HER -2-negative breast cancer patients, all of them in early stages of the disease.

In the early stages of the disease, however, tau proteins undergo changes that nudge them off microtubules.

The biological molecules increase the sensitivity of the material, meaning it can sense extremely low concentrations of substances, such as antibodies, and thus potentially detect diseases in their earliest stages.

«Patients diagnosed with early - stage prostate cancer — and that's the vast majority of patients with this disease — face many treatment options that are thought to be similarly efficacious,» said Ronald C. Chen, MD, MPH, UNC Lineberger member and associate professor in the UNC School of Medicine Department of Radiation Oncology.

The marker of antigens produced by pancreatic cancer has a low positive predictive value for identifying early stage disease.

The AUC for those patients was 0.87 for Stage I / IIA, 0.93 for Stage IIB and 0.89 for all early stages of the disease using the combination, pointing to a potential ability to detect disease in those who lack either of those known risk - raising conditions.

While women with early stage breast cancer often are cured of their disease, they live with surgical consequences throughout survivorship.

The neuroprotective effects of nicotine were studied in a randomized clinical trial involving 67 subjects in the early stages of Alzheimer's disease, where memory was slightly impaired but decision - making and other cognitive abilities remained intact.

«We believe that we have made an important step forward in minimising post-operative complications for patient with early HNSCC, enabling a more accurate identification of the stage of their disease, and reducing the cost to healthcare systems at the same time,» Prof de Bree will conclude.

«Based on the results of this study, the side of origin of CC [colon cancer](left vs. right) should be acknowledged as a criterion for establishing prognosis in both earlier and advanced stages of disease.

Adding two blood - borne proteins associated with cancer cell migration increases the predictive ability of the current biomarker for pancreatic cancer to detect early stage disease, a research team from The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer Institute.

As well as revealing step by step how disease and infection can aggravate and accelerate the early stages of Alzheimer's, Perry and his colleague Clive Holmes have begun a pioneering trial in 40 people to see if a drug that acts to dampen inflammation in the body can help delay the progress of the brain disease.

«Awareness of this silent, but deadly killer may help prevent those with early - stage kidney disease from progressing,» Saran says.

Although tau imaging is still in its earliest stages, Ryan hopes that such imaging will accelerate drug development and that finding a blood - based biomarker for Alzheimer's to reveal risk (much like cholesterol serves as a marker for cardiovascular risk) will change the field dramatically in terms of how doctors can diagnose the disease.

The team is now planning a larger trial in people who have earlier stages of the disease.

Genetically reprogramming late - stage human cancer cells to a stem - cell state enabled them to force the reprogrammed cells to progress to an early cancerous state, revealing secreted blood biomarkers of early - stage disease along the way.

Treatment of knee osteoarthritis is shifting focus from end stage treatment to preventing the progression from early to the late stage of the disease, with the specific aim of decreasing the need for joint replacement and other costly treatments.

The Duke medical researchers and ecologists who have joined that project hope to identify which species flourish in early stages of the human microbiome, how they are influenced by the consumption of breast milk, and what role they play in critical diseases affecting infants as well as in chronic diseases that occur later in life.

«Physical therapy not associated with improvements in patients with early stages of Parkinson's disease.»

These tangle - like structures appear at early stages of Alzheimer's and are not found in other neurodegenerative diseases such as Parkinson's disease.

She recently co-authored research appearing in the peer - reviewed Journal of Alzheimer's Disease that used state - of - the - art accelerometers to track daily physical activity of healthy people and those in the early stage of AD.

There is not only a great interest worldwide to understand the causes and consequences of fatty liver disease, but also to diagnose fatty liver disease at an early stage.

«Our findings show that a specific genetic marker (known as allele * 2 of the HS1, 2 A enhancer region) influences not just disease activity in RA patients, but also response to therapy in the early stages of their disease,» said lead investigator Dr Gabriele Di Sante of the Institute of Rheumatology and Related Sciences, Catholic University of the Sacred Heart, Rome, Italy.

The same was also seen for the sub-group of patients with early stage I disease.

A specific genetic marker influences response to therapy in the early stages of RA; a link thought to be due to the gene activating a cell - signalling protein involved in the inflammatory disease process.

Even if chimps never develop the symptoms of Alzheimer's, knowing that they spontaneously develop biological signs of the disease could yield useful information about its early stages and potentially how to prevent it, she says.

«Early identification of patients more likely to experience end - stage kidney disease is an urgent, unmet clinical need,» Kretzler says.