The lack
of effect of exercise on progranulin in older mice is similar to the pattern of exercise effects on hippocampal BDNF, which also decrease with age (Adlard et al., 2005a; van Praag et al., 2005).
Keep a track
of the effects of the exercises that you are doing.
As you can see, most
of these effects of exercise have to do with energy efficiency and utilization.
Not exact matches
Not eating enough, in combination with
exercising regularly puts the body at risk
of numerous short - term and long - term deleterious
effects.
Even five minutes
of moderate
exercise can create a mood - enhancement
effect.
According to the New York Times, scientists discovered that when we sit all day, «electrical activity in the muscles drops... leading to a cascade
of harmful metabolic
effects,» and sadly even getting regular doses
of exercise doesn't offset the damage.
«Walking is one
of the best
exercises,» Nirav says, «because
of its positive
effect on posture, sustainable intensity, and anyone can do it, anywhere!»
The only place the authors observed some benefits
of vitamin C supplementation was in marathon runners, skiers, and soldiers on «subarctic
exercise» — and even in those small populations, the observed
effect was small.
To gauge the
effects of this creative
exercise on the participants» stress levels, the research team tested their levels
of the hormone cortisol, a bodily marker
of stress, both before and after the art - making session.
Sessions himself has said a «properly
exercised» Civil Rights Division «provides tremendous benefit to American citizens» but should not be used as «a sword to assert inappropriate claims that have the
effect of promoting political agendas.»
There have been a number
of studies conducted into the
effects and benefits
of using caffeine while
exercising.
For context, it said that while «ergogenic
effects of caffeine on aerobic or endurance
exercise are well documented,» its impact on «high - intensity, primarily anaerobic performance, was not well understood.»
Beyond the fact that
exercising in the morning means they can't later run out
of time, Vanderkam says a pre-breakfast workout helps reduce stress later in the day, counteracts the
effects of high - fat diet, and improves sleep.
The print edition
of July's Vanity Fair doesn't hit newsstands until Tuesday, June 9, so until then, any speculation about the
effect of the Internet response on sales is a purely academic
exercise.
Any form
of consistent
exercise tends to result in a snowball
effect: Most people who stick with an
exercise program typically start eating better, too.
The suggestion comes from work done at the Donders Institute at the Radboud University Medical Center in the Netherlands, which examined the
effects of exercise on memory.
Leaving aside the fact that a relatively anemic 15 %
of Canadians are physically active enough to satisfy even modest government recommendations — Health Canada suggests 150 minutes per week
of moderate - to - vigorous physical activity — the evidence is mounting that you can not offset the deleterious
effects of sitting simply by
exercising more.
We don't need to wait and see the positive
effects of exercise on preventing heart attacks and dementia in later life.
24/7 Wall St. can tally up losses
of more than $ 25 billion that would be in
effect if Buffett were forced into an instant mark - to - market or similar
exercise.
in the case
of our directors, officers, and security holders, (i) the receipt by the locked - up party from us
of shares
of Class A common stock or Class B common stock upon (A) the
exercise or settlement
of stock options or RSUs granted under a stock incentive plan or other equity award plan described in this prospectus or (B) the
exercise of warrants outstanding and which are described in this prospectus, or (ii) the transfer
of shares
of Class A common stock, Class B common stock, or any securities convertible into Class A common stock or Class B common stock upon a vesting or settlement event
of our securities or upon the
exercise of options or warrants to purchase our securities on a «cashless» or «net
exercise» basis to the extent permitted by the instruments representing such options or warrants (and any transfer to us necessary to generate such amount
of cash needed for the payment
of taxes, including estimated taxes, due as a result
of such vesting or
exercise whether by means
of a «net settlement» or otherwise) so long as such «cashless
exercise» or «net
exercise» is
effected solely by the surrender
of outstanding stock options or warrants (or the Class A common stock or Class B common stock issuable upon the
exercise thereof) to us and our cancellation
of all or a portion thereof to pay the
exercise price or withholding tax and remittance obligations, provided that in the case
of (i), the shares received upon such
exercise or settlement are subject to the restrictions set forth above, and provided further that in the case
of (ii), any filings under Section 16 (a)
of the Exchange Act, or any other public filing or disclosure
of such transfer by or on behalf
of the locked - up party, shall clearly indicate in the footnotes thereto that such transfer
of shares or securities was solely to us pursuant to the circumstances described in this bullet point;
The number
of shares
of our Class A common stock outstanding after this offering as shown in the tables above is based on the number
of shares outstanding as
of September 24, 2014, after giving
effect to the Transactions and the Assumed Redemption, and excludes 5,952,917 shares
of Class A common stock reserved for issuance under our 2015 Incentive Award Plan (as described in «Executive Compensation — New Employment Agreements and Incentive Plans»), consisting
of (i) 2,689,486 shares
of Class A common stock issuable upon the
exercise of options to purchase shares
of Class A common stock granted on the date
of this prospectus to our directors and certain employees, including the named executive officers, in connection with this offering as described in «Executive Compensation --
Based on shares outstanding as
of December 31, 2016, on the closing
of this offering, we will have outstanding a total
of shares
of Class A common stock, shares
of Class B common stock, and shares
of Class C common stock, assuming no
exercise of outstanding options, and after giving
effect to the conversion
of all outstanding shares
of our preferred stock into shares
of Class B common stock on the closing
of this offering and the sale
of Class A common stock by the selling stockholders in this offering.
The number
of shares
of our Class A common stock outstanding after this offering as shown in the tables above is based on the number
of shares outstanding as
of September 24, 2014, after giving
effect to the Transactions and the Assumed Redemption, and excludes shares
of Class A common stock reserved for issuance under our 2015 Incentive Award Plan (as described in «Executive Compensation — New Employment Agreements and Incentive Plans»), consisting
of (i) shares
of Class A common stock issuable upon the
exercise of options to purchase shares
of Class A common stock granted on the date
of this prospectus to our directors and certain employees, including the named executive officers, in connection with this offering as described
Upon the completion
of this offering and after giving
effect to the planned recapitalization
of our common stock into a single class
of common stock and stock split, SIH will own shares
of our outstanding common stock (representing %
of the shares outstanding), our founders and their family trusts will own an aggregate shares
of our outstanding common stock (representing %
of the shares outstanding) and our employees who received shares upon the liquidation
of the special purpose employee ownership vehicle will own shares
of our outstanding common stock under a restricted stock award (representing %
of the shares outstanding), in each case as it relates to the percentage ownership assuming that the underwriters do not
exercise their option to purchase additional shares.
The diluted net income (loss) per share calculations include shares
of Class A, Class A-1, and Class B common stock, as well as warrants to purchase shares
of Class A and Class C common stock where the warrant
exercise price is below the fair value
of the underlying common stock and therefore would have a dilutive
effect.
These changes to the essential service regime will have the
effect of meaning that a larger number
of public servants can not
exercise their right to strike.
If at the Date
of Exercise, Participant is not in compliance with the Company's minimum stock ownership guidelines then in
effect for Participant's job grade or classification, if any, Participant will not be entitled to
exercise the Option using a «cashless
exercise program»
of the Company (if then in
effect), unless the net proceeds received by Participant from that
exercise consist only
of Shares and Participant agrees to hold all those Shares for at least one year.
You can get the same physiological, and psychological benefits
of prayer by meditating,
exercising, singing, humming, or making human connections, without the side
effects of irrationality.
The Court held that where a prohibition on the
exercise of religion «is not the object... but merely the incidental
effect of a generally applicable and otherwise valid provision, the First Amendment has not been offended» (494 US at 878).
Instead he speculates that they
exercise their
effects, not only in the realm
of physics but also in biology, in a manner open to experimentation.
Sheldrake pictures morphogenetic fields as being the context in which forms (
of life or physical reality) which arose in the past
exercise their causal influence by a non-energetic «resonance» with subsequent similar systems13 Resonance
of course is a physical analogy for something that is not physical: «A «resonant»
effect of form upon form across space and time would resemble energetic resonance in its selectivity, but it could not be accounted for in terms
of any
of the known types
of resonance, nor would it involve a transmission
of energy «14 In order to distinguish it from energetic resonance, Sheldrake calls this process morphic resonance.
The problem is one
of practical reason; but if reason is to be
exercised properly it must undergo constant purification, since it can never be completely free
of the danger
of a certain ethical blindness caused by the dazzling
effect of power and special interests.
That through which all religion lives, religious reality, goes in advance
of the morphology
of the age and
exercises a decisive
effect upon it; it endures in the essence
of the religion which is morphologically determined by culture and its phases, so that this religion stands in a double influence, a cultural, limited one from without and an original and unlimited one from within.
God, then, in Dr. Cumming's conception, is a being who has no pleasure in the
exercise of love and truthfulness and justice, considered as
effecting the well - being
of His creatures; He has satisfaction in us only in so far as we exhaust our motives and dispositions
of all relation to our fellow - beings, and replace sympathy with men by anxiety for the «glory
of God.»
In addition, the older Puritanism
exercised a powerful
effect on his imagination by its clarity, its drama, its understanding
of evil, and its contrast to the bland optimism and secularizing, genteel Protestantism and liberalism
of eastern New England in his time.
Only in a setting where the poor and the alien have a right to the produce
of the fields and where laws regarding land and family» were designed to prevent the rise
of a pertnanent underclass could Ruth's initiative have been
exercised with any
effect at all.
In relation to American religious culture, therefore, television has
exercised a major status - conferral
effect, not on the basis
of a representativeness, nor on a calculated moral - evaluative basis, but solely on the basis
of a correspondence
of a minority religious ethos with television's own economic, functional, and mythical goals.
Finally, secular individualism can defend legislative, but not judicial, free
exercise exemptions only by draining the free
exercise clause
of substantive content and
effect.
The works they perform might turn out to be helpful» though it would not be beyond the pale
of reason to have one's doubts about that» but the
effect on them, which is after all the object
of the
exercise, will only be to reconfirm the message society has for so long and so damagingly been giving them.
In the general theory
of relativity it has, as von Weizsäcker has said, become a «physical object in the full sense
of exercising action and suffering
effects.»
The evidence suggests that all
of these influences have indeed
exercised a negative
effect on traditional religious beliefs and practices.
Through its fusing
of the field
of force with space it has turned space into a physical object in the full sense
of exercising action and suffering
effects....
But this is not what is meant here, for von Weizsäcker said, «a physical object in the full sense
of exercising action and suffering
effects.»
It may be that Brown can be so sanguine about overcoming the fragmenting
effects of disciplinary diversity because the national scholarly organizations that institutionalize the various academic guilds today
exercised less political power in the 1930s over scholars» standing with peers, mobility from school to school, and promotion to tenure.
The movement
of man in this direction, long before he could
exercise control over his own development, is the
effect of the initial aim
of his own occasion
of experience combined with those in all the occasions making up his body.
Television's managers have
exercised a powerful censoring
effect on the expression
of religious faith in America, giving them consequentially an exaggerated influence over the development
of American religious culture and institutions and possibly over the nature
of American and even global religious life.
If my colleague Brad Gregory's historical assessment is true, and if Ephraim Radner's «Protestant version»
of the Reformation's purported beneficial
effects» that it «gave us back our consciences, granted us freedom, unleashed reason,» etc., and has given rise to modern secular institutions that have
exercised caritas even better than have Christian institutions» are arguable if not actually overstated, what then are modern Christians (Protestant and Catholic) to do in the face
of contemporary culture's relentless hostility to sacred things?
In a passage which deserves a great deal
of attention in our country, more than two centuries after it was written, he said: «The man whose life is spent in performing a few simple operations,
of which the
effects are perhaps always the same, or very nearly the same, has no occasion to exert his understanding or to
exercise his invention in finding out expedients for removing difficulties which never occur.
Do the sacraments
of the church stand for something ultimately real, or are they merely pious
exercises, valuable only because
of the psychological
effect they have on those who practice them?
(b) Notes
of the May meeting made well after it by Bishop Fliss,
of the diocese
of Superior, state that the CDF «was not encouraging us to proceed with any formal dismissal on the basis
of 24 yrs
of apparent good conduct and the precept impeding
exercise of orders currently in
effect».