Sentences with phrase «of effect over time»

A common difficulty in couples therapy research conducting a randomly controlled study with a control group and follow up to determine if there is a loss of effect over time.

The utilities were assumed to remain constant over time, with missing values imputed using predictive mean matching and complete cases only to generate estimates of the cost per QALY gained from FLNP over 5 and 10 - year time horizons, based on linear extrapolation of effect over time.

The sum (integral) of this effect over time will be shown in LOD (not it's rate of change), so decadal scale change in SST will be reflected in LOD.

But will have less of an effect over time.

Decay of the effect over time would be consistent with a training imprint that wanes because of practice environment.

So on average, we help clients get past some problems and improve their well - being, with some fading of effects over time from a single dose of therapy.

Nevertheless, given the brevity of the intervention, longer - term outcomes are likely to show further fading of effects over time.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

These effects help explain the recent announcement by Starbucks and several major American corporations of a program to offer full - time positions as well as apprenticeships and internships to 100,000 disconnected youth over the next three years.

So far, the effects of existing probiotic supplements have been all over the map — sometimes they help, but most of the time, they don't.

«Having spare time and perceiving control over how to spend that time (i.e. discretionary time) has been shown to have a strong and consistent effect on life satisfaction and happiness, even controlling for the actual amount of free time one has.»

Many of those new employees lose the halo effect over time as their imperfections start to surface.

Over time, as people became more and more aware of the effects commonly used products can have on the environment, plastic - happy clients who once cared mostly for cost and convenience morphed into savvy customers with real concerns about the impact polyethylene and other petroleum - based products have on the ecosystem.

The app produces a set of graphs so you can compare the effect a factor had on your symptoms over time or compare the severity of two symptoms.

According to the TPC, the economic effects would slowly decrease over time, with a GDP boost of just 0.4 % in 2021 and 0.1 % in 2026.

While Mathew Ingram over at GigaOm has argued that people have always found ways to distract themselves and waste time, perhaps by watching television, the reality is they've never had this sort of fire hose effect before.

Even though computer screens don't give off radiation, the strain from staring over long periods of time can cause harm to your vision, though many effects are temporary.

The series of studies tested the effects of power hierarchies on team productivity by creating teams with either a mixed propensity towards leadership — in one case some participants were primed to feel powerful by thinking of a time they wielded power over others while others subjects were asked to envision a time they were bossed around before joining the group — or teams made up entirely of hard charging leadership types or participants primed for a meeker, go along, get along approach.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

CAP assumes annual wage growth matches the mean effect of experience and nonexperience on real wages measured in the NLSY data assuming full - time, full - year employment, and reports the cumulative difference between the no - leave earnings profile and the leave earnings profile over time.

But none of globalization's effects on inflation, not even the potential reduction in inflationary bias, diminish the importance of the principal objective of central banks: setting policy to achieve low and stable rates of inflation over time.

Such conversions of Class B common stock to Class A common stock upon transfer will have the effect, over time, of increasing the relative voting power of those holders of Class B common stock who retain their shares in the long term.

As credibility builds over time, monetary policy does not have to respond to every hint of inflation, knowing that the small fluctuations in inflation over the course of the cycle will not have any permanent effects.

Since a larger share of deposit rates are fixed than are loan rates, this will overstate the effect on cash flows over longer time horizons, though the extent of this bias has not necessarily changed over time in an obvious way.

What social influencer lists don't account for is the cumulative effect of influence a person achieves over time and in the «real world».

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

Part of this decline in GDP, stemming from the oil production shortfall, will probably be made back sometime in the third quarter, but the net effect on the level of GDP over time will depend on the pace of rebuilding, which at present is difficult to foresee.

Critics of the Fed's easy - money policies say they had diminishing impact over time and subjected the nation to side effects that could lead to serious problems in the future.

They say the Fed's easy - money policies, including huge bond purchases and a seven - year period of record low rates, had diminishing effect over time and subjected the nation to side effects that could lead to serious problems in the future.

Over a long enough time period such effects tend to cancel out (a phenomenon called «regression to the mean»), thus it is unlikely that a firm is consistently high performing just because of chance events.»

Likewise, the frightening or exuberant features of any given business cycle typically have little effect on the very, very long - term stream of cash flows that stocks actually deliver over time.

Intermittent fasting over a certain period of time is a feature of great religions all over the world and it is well known that nutritional habits, sleeping patterns and meal frequency have profound effects on maintaining human health.

This is because interest rate changes have their largest effect on inflation risk, while stronger macroprudential settings will lead to a higher quality of household indebtedness over time.

This has the effect of depressing Mitel's revenues in the short term though over time the company's financial picture should improve.

Nevertheless, the early experience suggests that, while the resilience of both borrowers and lenders has no doubt improved, the initial effects on credit and some other indicators we use to assess risk may fade over time.

However, that approximation is less accurate over large movements or over extended periods of time, where growth in fundamentals and compounding effects become important.

Yet each time the requisite agreement has been impeded by various parties expressing concerns over the potential adverse effects of companion hikes in CPP premiums.

After maturity, if you choose to roll over your CD, you will earn the base rate of interest in effect at that time.

While it remains to be seen what the full effects of these two recent events will be, over time they are likely to prove to be healthy adjustments.

S&P noted that it expected that the breach will have a «somewhat lingering effect on customer traffic at least through the first half of fiscal 2014, but this should moderate over time.»

«t's actually quite hard to figure out how much of the change in median household incomes over time is due to Simpson's Paradox - type composition effects»

The fact is, the Earth's magnetic field has reversed thousands of times over the Earth's lifetime, with no apparent effect on it's rotation.

The same effect could have been achieved by temporary employment, as the Bible itself stipulates for Israelites (Lev 25:39)» @Chad «LOL you have ZERO understanding of the practice at the time, over 30 % of the Roman population was slaves.

Either they necessitate a deceptive «God», e.g. creating starlight «in transit» which means that for some light the star that supposedly sent said light would never have actually existed, or they would cause effect that should be evident but are not, e.g. temporarily fast starlight would effectively cook many things, such as life on earth, if the required light (and attendant gamma radiation) were compressed into a significantly shorter time frame (think of the radiation from the apparent 13 billion years of the universe arriving at the same time, or even over a 1000 years).

I personally think religion should not be a factor.No one should ask the candidates what their religious views are and they should never mention them.Their religious preferences have absolutely no effect on what type of leader they will be.Unless they are some kind of a religious fanatic.I think it's time for an atheist.There was not a Christian president for over the first 50 years of our nations existence.And, I do not think there has been one since.If you look it up you will find not one of our founding fathers were Christian.Not even Jefferson.I know he wrote the Jefferson bible, but, that's just because he, like the other founding fathers, did not believe Jesus to be of divine decent.So, he kept his philosophy while removing all the mystical and dogmatic concepts.

I would say guiding forces for me are not concretely one thing or another, but more of a culmination of many effects and experiences over time.

For our purposes, the medical and psychiatric therapies may be divided into three categories according to their purpose: (1) those therapies that aid in the physical rehabilitation of the person suffering from the effects of an acute binge and / or prolonged excessive drinking over many years; (2) those that help to keep the addictive cycle broken and thus maintain sobriety for sufficient time to allow other therapies to take effect; (3) those that aim at lessening the alcoholic's personality problems — both those that contributed to the causation of his addiction and those resulting from the interpersonal chaos of progressive alcoholism.

The few times when licenses have been withdrawn, the FCC has been ordered to do so by the courts, in effect, over the protests of the FCC itself.

Macroevolution is simply the acc - umlated effects of microevolution over longer time scales.

Despite formal separation of church and state, the effect of this arrangement over time has been to covertly control religious leaders by making it appear that the institutions they lead are the bulwark of democracy.