Sentences with phrase «of effective immune responses»

Our goal is to understand the acute immune response associated with viral infections to better identify and interdict these pathogens to increase blood safety, as well as to capitalize to access to subjects identified at the earliest point of infection to better understand the generation of effective immune responses against acute and chronic viral infections.

The cholera studies led to the scuttling of a leading vaccine candidate, a finer understanding of effective immune responses, and, ultimately, compelling evidence that a different cholera vaccine worked.

An intervention would be ethically justified if the likelihood of an effective immune response significantly outweighs the risk and severity of adverse reactions to the intervention.

Regarding treatment for Canine Infectious Hepatitis, the virus will typically eventually run its course, but aforementioned supportive are sometimes useful in stabilizing the patient to enable the mounting of an effective immune response to hasten recovery.

Not exact matches

Many moms default to soy formula if their baby is reacting to a cow's milk version, but this is not necessarily the most effective move — soy protein may still cause an immune response and allergic sensitization (although less than that of cow's milk).

«This research represents a big step forward in understanding why some tumors are more aggressive than others and being able to predict rationally which neoantigens will be the most effective at stimulating an immune response,» said Dr. Balachandran, a member of the David M. Rubenstein Center for Pancreatic Cancer Research at MSK, and corresponding author of the companion study in Nature.

On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.

Professor Nutt said increasing our knowledge of the mechanisms that controlled the immune response was vital for understanding how immune and inflammatory diseases arise and, ultimately, developing more effective treatments.

«The amphibian chytrid fungus suppresses immune responses of amphibian hosts, so many researchers doubted that amphibians could acquire effective immunity against this pathogen,» Rohr said.

«The effective immune response didn't happen in every tumor model we tested, so we still need to figure out exactly what triggered the tumor shrinkage and how to predict which tumors will shrink in response to virotherapy,» said Leddon, who is also working toward her medical and doctoral degrees at the University of Cincinnati.

«We are pleased to have demonstrated such a potent and durable immune response to the vaccine,» said the study's lead author, Sita Awasthi, PhD, a research associate professor of Infectious Diseases at Penn. «If found effective in clinical trials, the vaccine will have a huge impact on reducing the overall prevalence of genital herpes infections and could reduce new HIV infections as well, especially in high - burden regions of sub-Saharan Africa.»

«The strategy of using peptides that mimic regions of a human immune receptor, to put the brakes on the excessive inflammatory response triggered by superantigen toxins, is a host - oriented strategy that is broadly effective against the diverse family of superantigens,» said Prof. Raymond Kaempfer.

Adjuvants can stretch the amount of vaccine made from a given amount of viral protein and reduce the number of shots needed to trigger an effective immune response.

To develop an effective vaccine, it is imperative to identify a suitable antigen structure of the virus which will create an effective immune response in humans.

Antiviral drugs can suppress the amount of HIV in the body to nearly undetectable levels, but only an effective immune response can eradicate the virus.

This discovery lays the groundwork for a better understanding of the role progenitor cells can play in immune system response and could lead to the development of more effective therapies for a wide range of diseases.

«Although data clearly indicate better immune responses and vaccine efficacy against both genital warts and cervical dysplasia when vaccination occurs before age 14, this study suggests that HPV vaccination may be effective in reducing abnormal Pap test results even after sexual debut,» explained co-author Rebecca Perkins, MD, MSc, assistant professor of Obstetrics and Gynecology at Boston University School of Medicine and a gynecologist at Boston Medical Center.

«We learned in this study that grabbing hold of these glycans can be a very important early step in an effective immune response to HIV, and with this knowledge, we believe we can design better candidate vaccines,» said principal investigator Dennis R. Burton, professor of immunology and microbiology at TSRI.

Moreover, going for the starches instead of proteins seems to delay the moth's ability to mount an effective immune response against this unwanted guest, the scientists report.

In their latest study, researchers at La Jolla Institute for Allergy and Immunology identified a key signal that drives the commitment of immature Tfh cells into fully functional Tfh cells and thus driving the step - by - step process that results in a precisely tailored and effective immune response.

«Our findings suggest that different prostaglandins have different roles in antiviral immunity and that specific inhibition of PGE2 will be an effective therapy against influenza viral infection by boosting immune responses.»

Unfortunately neither approach is totally effective, and in the case of dampening the immune response, can have significant drawbacks.

Cancer vaccines, engineered to continue to train T cells to mount a strong immune response against your cancer, also haven't been very effective at mounting a strong fight, says He, and likely one weak point is the lack of strong receptors.

Despite decades of attempts to develop effective cancer treatment vaccines, they have mostly failed at producing potent antitumor immune responses.

The vaccine, if effective, would be given in two doses, one to prime the immune system to recognize these dangerous invaders, and a booster shot of a different vaccine that would amplify the immune response.

Renal Carcinoma Immunology Laboratory: The overall goal of this laboratory research effort is to understand how renal tumors can inhibit the development of an effective anti-tumor immune response.

We are confident that, as a potent activator of the innate immune response, motolimod will prove even more effective as a component of combination immunotherapy.»

Because hemagglutinin also happens to be the part of the flu vaccine that induces an immune response in people (it's the H in a virus name like H5N1), each mutation renders the vaccine less effective.

«However, the unexpectedly large proportion of maternal blood cells in the fetus made us think that perhaps it was the maternal, rather than the fetal, immune response that poses the real barrier to effective stem cell transplantation.»

The hallmark of an effective T cell response is the formation of a stable long - lived population of cells that mediate immune memory.

These findings lead to the hypothesis that impaired immune responses in the elderly to infection or vaccination reflects dysregulation of immunoregulatory pathways and metabolic pathways, which work in concert to orchestrate an effective immune response in young healthy individuals.

The primary focus will be to work as a member of the team responsible for delineating the immune response against nairoviruses to aid effective vaccine design.

A new paper published in the February 2018 issue of Immunity by La Jolla Institute for Allergy and Immunology (LJI) researcher Yun - Cai Liu, Ph.D., reports mechanisms used by a subgroup of ILCs, known as ILC2 cells, to undergo maturation required for them to mount an effective immune response.

Since immune responses to vaccines can differ around the world, these findings are encouraging for the development of an effective Ebola vaccine for Africa,» said Merlin Robb, M.D., Director for Clinical Research at the US Military HIV Research Program (MHRP), whose site in Uganda, Makerere University Walter Reed Project (MUWRP), conducted the study.

In this study, investigators identified a mechanism that boosts the ability of regulatory T cells to cause problems by blocking an effective anti-tumor immune response.

Through long - established collaborations in Durban and Kimberley, these studies in particular seek to define: the immune responses that are effective in control of HIV infection; the impact of HLA - mediated selection pressure on HIV at the individual and population level; the mechanisms of HIV non-pathogenicity; the nature and consequences of ontogeny of the virus - specific immune response; and finally the prospects for interventions including antiretroviral therapy, alone or in combination with broadly neutralising antibodies and / or T - cell vaccines, to achieve HIV eradication.

NIMML researchers employ advanced computational tools in combination with experimental and clinical studies to capture variation and diversity of immune responses, and develop safer, more - effective precision medicine treatments for infectious and immune - mediated diseases.

We found that old animals bearing CD8 + TCE within Vbeta10 or Vbeta8 families failed to mount an effective immune response against HSV - 1, as judged by reduced numbers of peptide - major histocompatibility complex tetramer + CD8 T cells and an absence of antiviral lytic function.

BSI member Professor Michael Dustin, explains, «While an overwhelming T - cell response might on the face of it sound effective, it brings risks of immunopathology, where an over-active immune system destroys healthy human tissue, not just the invading disease - causing pathogen.

Immune Design is a new generation vaccine company built on emerging understanding of the role of dendritic cells in determining an effective immune response.

The innate immune system is a critical component of host defence against microbial pathogens, but effective responses require an ability to distinguish between infectious and non-infectious insult to prevent inappropriate inflammation.

Development of a focused immune response, possibly induced through vaccination, may be an effective strategy to promote protection to Ct infection.

Evidence is accumulating that DHEA may be effective as a treatment for the immunological abnormalities that arise in subjects with low circulating levels of this hormone, including the impaired immune response of older individuals and immune dysregulation in patients with chronic autoimmune disease.93

The risk of progressing to neurodistemper is less in adult dogs as they tend to mount more effective immune responses than puppies do.

Cats may mount a good immune response and contain infection effectively, resulting in a «regressive infection» - the virus may still be present in some cells, but an effective immune response stops widespread replication of the virus.