Hear about the Science Exchange's Reproducibility Initiative, which aims to reward high - quality, reproducible research and provide a mechanism for industry to identify robust new drug targets for the development
of effective new therapies.
Not exact matches
Like
effective and respectful
therapy, persuasion brings about
new wants and aims, but it does so, not by coercion or by frustrating desires, but by opening
new possibilities, which is the result
of divine «creativity.»
The principles that have emerged thus far are these: We should seek
new knowledge
of our genes (and we can say this without deciding whether the Human Genome Initiative is the wisest and most cost -
effective way to do so) We should seek
therapies for the genetic disorders that afflict many people.
Creator
of an
effective new model
of relationship repair (Emotionally Focused Couple
Therapy), she has written numerous articles and trained thousands
of therapists around the world.
A number
of new, highly
effective therapies to treat both Hepatitis C and HIV / AIDS have been approved by the Food and Drug Administration in recent years, but their extraordinary costs have raised questions about states» ability to pay the sticker price.
While many researchers have tried to identify
effective new therapies to mitigate motor function impairment and enhance quality -
of - life, discoveries have been lacking.
Not so, the authors
of the
new research suggest: The three
therapies were equally
effective.
Despite current standard
of care, the prognosis for patients with PDAC is poor and
effective new therapies are needed.
«It is expected that this study will lay the foundation for developing a
new class
of potent and
effective cancer
therapies and the development
of reagents targeting epigenetic events in immune - mediated diseases as well as other epigenetically - influenced diseases,» said Alani, who also is chief
of dermatology at Boston Medical Center.
«Unsuspected characteristics
of new cystic fibrosis drugs found, offering potential paths to more
effective therapies.»
«Early diagnosis,
effective therapy vital for treatment
of deadly invasive aspergillosis:
New guidelines focus on new treatments, early diagnosis of fungal infection.&raq
New guidelines focus on
new treatments, early diagnosis of fungal infection.&raq
new treatments, early diagnosis
of fungal infection.»
«By helping us understand that lower levels
of RNF125 confer resistance to BRAF inhibitors, we have a
new strategy to stratify patients for currently approved
therapy versus participation for human clinical trials to investigate whether targeting JAK1 will be more
effective in patients whose tumors exhibit reduced RNF125,» said Keith T. Flaherty, M.D., associate professor, Harvard Medical School, and director
of Developmental Therapeutics, Cancer Center, Massachusetts General Hospital, and co-author
of the study.
Hormone replacement
therapy (HRT) is the most
effective treatment for menopausal symptoms, in particular for younger women at the onset
of the menopause, suggests a
new review published today (19 December) in The Obstetrician & Gynaecologist (TOG).
Payment vouchers eliminated price differences between an older generic
therapy called clopidogrel and a
newer, more
effective version
of the
therapy, ticagrelor.
The
new therapy has successfully gone through a pilot study with six patients conducted at the Singapore National Eye Centre and has yielded exceptional results, having shown to be both safe and
effective in the treatment
of glaucoma.
Electroconvulsive
therapy remains one
of the most
effective treatments for severe depression, but
new UNSW research shows ultra-brief pulse stimulation is almost as
effective as standard ECT, with far fewer cognitive side effects.
«Our findings may not only help to understand the causes
of depression, but also may provide a
new biochemical target for developing more
effective therapies.»
The NIHR Leicester Respiratory Biomedical Research Unit — a partnership between the University
of Leicester and Leicester's Hospitals — focuses on promoting the development
of new and
effective therapies for the treatment
of respiratory diseases including severe asthma and chronic obstructive pulmonary disease (COPD).
«The complex pathophysiology
of schizophrenia and resultant patient heterogeneity present significant challenges to developing
new and
effective therapies for this disorder,» said corresponding author Dr. Bruce Kinon
of Lundbeck LLC.
And while
new therapies have been
effective in releasing the immune system's restraints to unleash the body's own cancer - fighting powers, they only work in about half
of melanoma patients and often lose their potency as the cancer develops resistance.
«At Exeter we are already developing specific psychological
therapies, running clinical trials
of novel drug approaches and using - cutting edge genetic techniques to identify
new targets for safe and
effective therapies and to allow us to use current treatments in a more focussed way.»
A
new study published in the International Journal
of Molecular Sciences, describes a
new concept
of how these two cancers may evolve in a similar way and may eventually lead to more
effective therapies for both.
According to Saura, «this study opens up
new perspectives on therapeutic prevention and treatment
of Alzheimer's disease, given that we have demonstrated that a gene
therapy which activates the Crtc1 protein is
effective in preventing the loss
of memory in lab mice».
«This could help revolutionize cardiology research by improving the ability to efficiently discover, design, develop and deliver
new therapies for the treatment
of heart disease, and by providing more efficient screening tools to identify and prevent cardiac side effects, ultimately leading to safer and more
effective treatments for patients suffering from heart disease.»
The real value
of the
new research may be that these receptors can provide
new and more
effective therapies for current addicts, says Michael Nader, a physiologist and pharmacologist at the Wake Forest University School
of Medicine in Winston - Salem, N.C. «This identifies a target,» he says.
Knowing what these defenses are could lead to
new ways
of making existing
therapies more
effective.
«The turbulent healing powers
of plasma: By revealing the origins
of turbulence,
new computer simulations may lead to more
effective medical
therapies using plasma.»
He adds, «We have shown in a previous study that mindfulness group
therapy is just as
effective as individual CBT for the treatment
of typical depression and anxiety symptoms; something we also observed in the
new study.»
The results from our
new study suggest that entinostat may enhance the anti-tumor efficacy
of PD - 1 targeted
therapy through MDSC targeting, potentially providing an
effective combination treatment approach for patients with solid tumors, including lung and renal cell carcinoma.»
While a
new generation
of safer, more
effective oral medications to treat hepatitis C patients may cost tens
of thousands
of dollars for a 12 - week regiment, investing in these
new therapies could generate savings estimated at more than $ 3.2 billion annually in the U.S. and five European countries, according to a
new study (abstract 228) released today at Digestive Disease Week ® (DDW) 2015.
The field has experienced monumental challenges developing
new and
effective drug
therapies, not the least
of which was the discovery that — until recently - clinical trials were conducted where up to 30 %
of participants did not have the Alzheimer's disease - related brain change targeted by the experimental drug.
More than 11,880
new cases
of GBM were estimated to occur in 2015, with overall survival averaging 12 to 15 months, so there is an urgent need for more
effective therapies.
«Although surgical
therapy is remarkable and
effective, it is incumbent on us to move to a higher genetic level
of understanding
of these diseases,» said senior author John Elefteriades, M.D., the William W. L. Glenn Professor
of Surgery (Section
of Cardiac Surgery) at Yale School
of Medicine, and director
of the Aortic Institute at Yale -
New Haven Hospital.
Scientists have been trying to identify antibodies that can attack all strains
of the Ebola virus; this
new technology will improve their chances
of developing an
effective therapy.
New studies from the Abramson Cancer Center
of the University
of Pennsylvania are providing fresh clues on potentially
effective combinations with CAR T
therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding
of the mechanisms
of resistance in pancreatic cancer.
Treatment success rate
of drug - resistant tuberculosis in HIV - positive patients is low and requires more
effective regimen using
new drugs compatible with antiretroviral
therapy.
«It suggests to us that targeting the pathways used in regulating cell fate decisions — how stem cells choose between cell proliferation and differentiation — could be a more
effective way
of halting tumours in their tracks and lead to potential
new therapies.»
UCLA Researchers are dedicated to understanding the mysteries
of how the brain develops and works, what goes wrong in brain diseases, and developing
effective new therapies to treat diseases from brain tumors, depression and Alzheimer's disease.
High throughput screening in motor neurons is a
new approach to identifying
effective therapy for SMA, said Lee L. Rubin, PhD, Senior Vice President for Research and Development and Chief Scientific Officer for Curis, Inc., and former Professor
of Anatomy and Developmental Biology and Director
of the Eisai Institute at University College in London.
This strategy is expected to improve early diagnoses and intervention, predict the course
of a disease, identify
new drug targets and select the most
effective therapies for individual patients.
At 13 different
New Jersey locations, our pediatric specialists partner with families to make our many innovative
therapies and medical treatments more personalized and
effective... so children can achieve more
of their goals.
For a
therapy involving
new cancer medicines to be
effective, the mutation status
of the tumour must be known.
At thirteen different
New Jersey locations, our pediatric specialists partner with families to make our many innovative
therapies and medical treatments more personalized and
effective... so children can achieve more
of their goals.
Additional insight into the biology
of ER - positive breast cancers, particularly the higher risk luminal B cancers, could aid in identifying potential targets and
new,
effective therapies.
The
new studies identify activation
of endothelial Toll - like receptor 4 by Gram - negative bacteria as a critical event in formation
of cerebral cavernous malformations, a significant predisposing condition for stroke and seizure for which
effective medical
therapies are lacking.
The Lymphoma Program is dedicated to the integration
of laboratory and clinical research to increase our understanding
of lymphoma and to develop
new, more
effective therapies for these conditions.
These results reveal
new risk markers in the genome that could be used to predict which children are likely to respond poorly to albuterol and other current first - line anti-asthma drugs, and to guide the development
of new therapies that will be more
effective and reduce the outsize burden
of mortality in minority populations.
CAR T - cell
therapy targeting B - cell maturation protein may be a
new effective type
of immunotherapy treatment for patients with multiple myeloma.
New research into CAR - T cell
therapy has revealed crucial mechanisms that could help the immunotherapy technique, which is currently only
effective against blood cancers, be adapted for the treatment
of brain tumors and other forms
of solid cancers.
The Leukemia Program is dedicated to integrating laboratory and clinical research to increase our understanding
of leukemia and to develop
new, more
effective therapies for the disease.