Sentences with phrase «of efflux pump»

The genes MDR1 and NANOG, both involved in the regulation and expression of efflux pump mechanisms, were significantly suppressed.

«After more extensive analysis, we narrowed down our list to predict which molecules were most likely to disrupt the function of the efflux pump.»

One type of efflux pump, which until recently had only been studied in parts, was recently modeled in its entirety and simulated using supercomputers at Los Alamos National Laboratory.

To address this challenge, our research group is using nanoparticles not only to deliver more chemotherapy drugs to the target site within cancer cells, but also to compromise the function of the efflux pumps and thereby significantly improve safety and efficacy of cancer therapy.»

The findings, published November 28 in Scientific Reports, offer a better understanding of the motions and functions of efflux pumps.

If a pathogenic strain of bacteria acquires a gene encoding one of these efflux pumps, then it will suddenly become resistant to multiple antibacterial drugs.

Application of these computational techniques to the multitude of efflux pumps found in different Gram - negative pathogens should allow scientists to elucidate if general mechanisms are shared among different pumps or are pump - specific.

«We study a lot of efflux pumps to understand antibiotic resistance,» said Yu, an Iowa State professor with appointments in physics and astronomy; chemistry; biochemistry, biophysics and molecular biology; and the U.S. Department of Energy's Ames Laboratory.

Not exact matches

Fortunately, efflux pumps require a source of chemical energy to perform their function.

Recognizing this, He and his research team developed a way to reduce the amount of chemical energy — adenosine triphosphate (ATP)-- available to the efflux pumps in cancer cells.

We thought, if the latter scenario is operative, then a molecule comprising the minimal portion of the ADEP that is recognized by the pump could competitively interfere with efflux of the ADEP.»

«There are efflux pumps that can export multiple drugs that have different structures and mechanisms of action.

Bacterial efflux pumps, such as the P. aeruginosa MexAB - OprM pump shown here, are one of the dominant molecular mechanisms available to Gram - negative pathogens for removing toxins, including antibiotics.

New supercomputer simulations have revealed the role of transport proteins called efflux pumps in creating drug - resistance in bacteria, research that could lead to improving the drugs» effectiveness against life - threatening diseases and restoring the efficacy of defunct antibiotics.

It had been reported that the ADEP resistance of M. tuberculosis was due to the presence of one or perhaps more efflux pumps.

Since an efflux pump could compromise the potency of even a newly developed antibacterial drug, we need to think about ways to circumvent these efflux pumps.»

Some coded for multi-drug efflux pumps, which are multi-drug resistance mechanisms embedded in the bacterial membrane that pump specific antibiotics out of the bacteria.

Heterogeneity in a bacterial population that arises through a mechanism of biased partitioning of drug efflux pumps, as we identified in our study, could be a stepping - stone on the path of bacterial populations towards antibiotic resistance.»

Saint Louis University researchers then synthesized structural analogs of the discovered efflux pump inhibitors and identified properties essential for their activities.

«As a first in this field, we proposed the approach of essentially «screwing up» the efflux pump's protein assembly, and this led to the discovery of molecules with a new type of antibacterial activity,» said co-author Jeremy Smith, who serves as a UT - ORNL Governor's Chair and director of the UT - ORNL Center for Molecular Biophysics.

The researchers found four new chemicals that seek out and disrupt bacterial proteins called «efflux pumps,» known to be a major cause of antibiotic resistance.

They plan to leverage a recently awarded Innovative and Novel Computational Impact on Theory and Experiment (INCITE) allocation from DOE to perform larger simulations on the Titan supercomputer to gain deeper understanding of how bacterial efflux pumps function, identify more potent efflux pump inhibitors and optimize the best antibiotic - plus - inhibitor combinations to make them suitable for clinical trials.

This picture was suddenly complicated in 1999, when Gerd Jürgens and his colleagues at the University of Tübingen in Germany discovered a mutant of the model plant Arabidopsis with efflux pumps everywhere in the cell.

Specifically, these investigators showed that the levels of several efflux (P - glycoprotein, MRP1, ABCG1) and influx (SLC15A1) pumps were found to increase by several fold within hours of adjudin treatment (27).

Similarly in C. neoformans, Chr 1 disomy confers azole resistance because this chromosome harbors ERG11 and AFR1 (which encodes the major azole efflux pump) and aneuploidy can also influence the virulence of this pathogen [16], [20], [21].

Efflux pumps are surface proteins that prevent antimicrobial drugs from getting a foothold in a bacterial cell by identifying and pumping them out of the cell.

Among other things, we have identified one mechanism of multi-drug resistance (MDR) involving P - glycoprotein (Pgp) which functions as a drug efflux pump of broad specificity.

Furthermore, if an agent is able to penetrate one or both of these membranes, it is often subject to rapid efflux out of the cell by numerous broadly acting efflux pumps - rendering the agent ineffective.

: This study evaluated the effects of an antagonistic analog of growth hormone - releasing hormone, MIA - 602, on tumor growth, response to doxorubicin, expression of drug resistance genes, and efflux pump function in human triple negative breast cancers.

Introduction: This study evaluated the effects of an antagonistic analog of growth hormone - releasing hormone, MIA - 602, on tumor growth, response to doxorubicin, expression of drug resistance genes, and efflux pump function in human triple negative breast cancers.

We examined the effects of treatment on tumor growth, drug resistance, GHRH - R levels, expression of MDR1 and Nanog, and efflux pump activity.

In - vitro cell culture assays were used to analyze the effect of MIA - 602 on efflux pump function.

That's kind of what efflux pumps do.