Sentences with phrase «of embryonic mouse»

The human - specific gene ARHGAP11B is expressed only in the right half of this embryonic mouse cerebral cortex.

They found that the combination of the transcription factors Brn3a plus Ngn1, or Brn3a plus Ngn2, reprogrammed a significant percentage of the embryonic mouse fibroblasts into what looked — and acted — like mature DRG - type sensory neurons.

The current research team, which includes Dr. Minoda and Dr. Hiroki Takeda of Kumamoto University, and several researchers from Keio University, have successfully grafted human iPS - derived cells into the inner ear of embryonic mice, a feat with a high level of technical difficulty.

Furthermore, transplantation into the inner ears of embryonic mice was successful.

When the FGF8 gene was injected into or removed from the front part of the brains of embryonic mice, structures toward the front became elongated or foreshortened, respectively.

Not exact matches

He wrote papers like «Cloning and characterization of mouse brush border myosin - I in adult and embryonic intestine.»

They confirmed these same opposite patterns of SMA protein and SMN lnc - RNA in embryonic mice too.

«Our research on mice and rats shows that these chemicals affect the embryonic development of these animals.

Menke and postdoctoral researcher Carlos Infante examined patterns of enhancer activity in embryonic limbs and genitalia of mice and limbed reptiles (anole lizards).

The ability of SIF - seq to use reporter assays in mouse embryonic stem cells to identify human embryonic stem cell enhancers that are not present in the mouse genome opens the door to intriguing research possibilities as Dickel explains.

The scientists rescued the microcephaly during mouse embryonic development by removing a protein that caused the loss of stem cells.

Repeated transfection of two expression plasmids, one containing the complementary DNAs (cDNAs) of Oct3 / 4, Sox2, and Klf4 and the other containing the c - Myc cDNA, into mouse embryonic fibroblasts resulted in iPS cells without evidence of plasmid integration, which produced teratomas when transplanted into mice and contributed to adult chimeras.

The study results were found using mouse embryonic stem cells, which are good cell models for the study of processes seen in human stem cells.

Base oxidation regulates gene activity In cooperation with colleagues at LMU, as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of mice.

For this study, Guttridge, first author David J. Wang, who developed many of the study's concepts, and their colleagues monitored NF - kB activity during tumor development using mouse embryonic fibroblasts and two mouse models.

Scientists have known for 20 years that SMN is necessary in every cell of the body, since disrupting the gene in a mouse causes early embryonic death, before muscle or nerve cells form.

So Harkany and his colleagues cultured mouse embryonic brain cells that expressed cannabinoid receptor proteins (CBRs) and exposed them to gradients of synthetic cannabinoids.

Here (from left to right), they're shown on the embryonic skin of a mouse, a snake, a chicken and a Nile crocodile.

During embryonic development of mice, however, the situation is different: To build up the system, all mature blood and immune cells develop much more rapidly and almost completely from stem cells.

The only previous demonstration — by researchers led by Shou - Wei Ding, PhD, a professor of Plant Pathology and Microbiology at UC Riverside and co-corresponding author of the current study — was done in embryonic stem cells and in newborn mice.

In collaboration with Ding, the lab of Olivier Voinnet at the Swiss Federal Institute of Technology in Zurich also reported in an accompanying paper the detection of viral siRNAs in cultured mouse embryonic stem cells infected by the Encephalomyocarditis virus.

The research team used mass spectrometry to compare phosphorylation of proteins from mouse embryonic stem cells with fully functioning GSK - 3 to cells in which the gene encoding GSK - 3 had been deleted.

Mouse embryos: Scientists first found embryonic stem cells in mice in the 1970s, but an understanding of the critical role they play in cell differentiation only emerged years later.

Now you know that if you take a mouse embryonic stem cell that is, say, labeled so all of the developed cells will be blue, and you inject it into a mouse blastocyst, you'll get a chimera.

The paper doesn't include any genetic analysis of the final eggs that confirms they are healthy, notes Mitinori Saitou, a stem cell biologist at Kyoto University in Japan whose team developed methods to create mouse egg cells from embryonic or reprogrammed stem cells.

Early in embryonic development, both mouse and human placentas rely on the same set of ancient cell - growth genes.

Upon further investigation, the team found that Noxo1 is highly expressed in the embryonic inner ear of normal mice, though its expression drops sharply after birth.

In the past few months, researchers in the United States and Japan have described a promising way of deriving embryonic stem cells from skin cells (of mice) without destroying embryos — the «Holy Grail of biotechnology,» as The Times of London put it.

• A team led by Ron McKay at the National Institute of Neurological Disorders and Stroke in Bethesda, Maryland, turned mouse embryonic stem cells into isletlike cells, another step down the long road to a cure for diabetes.

One of the greatest came in November 2007, when scientists in Japan and the United States reported that they could make adult skin cells from mice revert to the embryonic state.

Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.

A tooth grown from embryonic cells has been successfully transplanted into the jaw of a mouse.

Wondering why the third protein, an enzyme called p66, was not, despite being very similar to the other two, Pelicci's team knocked out the piece of the gene that enabled it to code for p66, in order to make mice and mouse embryonic cells that lacked p66.

«Observing the changes in the architecture of islets during embryonic development in mice and in pseudoislets — a model we generated in our lab — was also very interesting.

The researchers confirmed Olig2's role in promoting motor neuron formation by increasing or blocking the function of Olig2 in the spinal cords of developing mouse and chicken embryos, as well as during motor neuron formation in mouse embryonic stem cells.

When he injected mice with embryonic stem cells genetically identical to the mice's own tissues, the new cells thrived, growing into a large clump of adult tissues.

Manuel Eguren has analysed the biological consequences of Cdh1 elimination in rapidly dividing cells, as part of his doctoral research project in Malumbres's group; he focused on progenitors from the nervous system during embryonic development in mice.

«Fear was three times less likely to return in mice that had received a transplant of embryonic neurons»

All of the mice produced normal amounts of SOX2 during development, when the transcription factor plays a critical role in the genesis of embryonic and neural stem cells.

Mitchell and her colleagues eliminated this possibility when they deleted these nearby regions in the genome of mice and found there was no impact on the gene's ability to be turned on in embryonic stem cells.

After analysing the presence of NANOG in different mouse tissues by immunohistochemistry, the CNIO team demonstrated that, in addition to being present in embryonic tissue, this factor is also found in stratified epithelia such as the esophagus, skin or vagina.

These are images of mouse embryonic stem cells which grow in a round colony of cells (A) and express Sox2 (B), shown in red.

«We studied how the Sox2 gene is turned on in mice, and found the region of the genome that is needed to turn the gene on in embryonic stem cells,» said Professor Jennifer Mitchell of U of T's Department of Cell and Systems Biology, lead invesigator of a study published in the December 15 issue of Genes & Development.

Other mice had implants of dead embryonic brain cells for comparison.

Yong - Chun Yu at Fudan University in Shanghai, China, and his team wondered if fearful adult mice could be helped by a transplant of embryonic brain cells.

Confocal microscopy image showing a spinal cord section of a mouse embryo (embryonic day 11.5).

Similar SH3 binding motifs exist in the formins, proteins that function in pattern formation in embryonic limbs of the mouse, and one subtype of the muscarinic acetylcholine receptor.

McKay announced that he had mitigated the symptoms of Parkinson's in rats by using mouse embryonic stem cells that he had turned into dopamine - producing brain cells.

Three teams of scientists reported earlier this year that they had directly reprogrammed adult mouse skin cells into embryonic cells, although the process involved viruses and cancer - causing genes.

Embryonic stem (ES) cells, harvested from three - and - a-half-day-old mouse embryos or five - and - a-half-day-old human embryos, are referred to as pluripotent because they can become any of the thousands of cell types in the body.