In addition, Dr. Reinholdt's laboratory developed a novel protocol for derivation
of embryonic stem cell line from a variety of strains that were previously deemed recalcitrant after years of failed attempts by the scientific community.
The National Institutes of Health (NIH) has allowed a contract for the dissemination
of embryonic stem cell lines approved for US government funding to lapse, shuttering a key stem cell bank, and doubling the price researchers pay for samples of some human embryonic stem cell (hESC) line... from $ 500 per vial of frozen cells to $ 1,000.
Collins and others argue not just for a permanent removal of the injunction to resume research with confidence, but also for an extension of the number
of embryonic stem cell lines available to federally funded researchers.
Under the Obama administration, the number
of embryonic stem cell lines available for federally funded research had more than tripled, but no money was going toward the creation of any cell lines (a process that destroys the embryo).
The National Institutes of Health (NIH) has allowed a contract for the dissemination
of embryonic stem cell lines approved for US government funding to lapse, shuttering a key stem cell bank, and doubling the price researchers pay for samples of some human embryonic stem cell (hESC) lines.
Nevertheless, the religious and political right has decried the development
of embryonic stem cell lines, and George W. Bush severed federal funding for their development.
Not exact matches
Not surprisingly, President Obama received high marks from the journal, largely because his response to the question
of whether he would lift Bush's ban on the federal funding
of new
embryonic stem -
cell lines is in
line with the view
of most in the scientific community.
In August
of last year, President Bush approved the use
of federal funds to support research on a limited number
of existing human
embryonic stem cell lines.
Advocates
of embryonic stem cell research were thought to be in a long
line of pioneers fighting the restraints
of religious doctrine to push forward with scientific research.
He ruled that work on existing
embryonic stem cell lines derived outside federally funded labs did not violate a ban on the destruction
of embryos.
The year's most prominent science issue, federal support
of embryonic stem cell research, is so controversial that the sons
of Ronald Reagan gave dueling speeches at the opposing party conventions; Michael Reagan backs President George W. Bush's policies, including the ban on funding for research on new
stem cell lines, while Ron supports Senator John Kerry's promise to lift restrictions.
Congressional supporters
of stem cell research have re-introduced legislation to codify President Barack Obama's 2009 executive order lifting restrictions on the number
of human
embryonic stem cell lines available to federally funded researchers.
CMRB has two parts: the
Cell Line Bank of Barcelona, which generates and maintains embryonic stem cell lines, and the CMRB research centre, which carries out basic and applied research to design future strategies for regenerative medic
Cell Line Bank
of Barcelona, which generates and maintains
embryonic stem cell lines, and the CMRB research centre, which carries out basic and applied research to design future strategies for regenerative medic
cell lines, and the CMRB research centre, which carries out basic and applied research to design future strategies for regenerative medicine.
In addition, where
cells derived from
embryonic stem cells are great at proliferating — a potentially critical feature if one wants to grow sufficient numbers
of cells for clinical use — ones from the iPS
lines were much feebler.
He has also been an inveterate foe
of abortion, a position that informed his repeated votes against expanding the number
of human
embryonic stem cell lines available to NIH - funded researchers during the George W. Bush administration.
But just how close adult and reprogrammed
stem cells can come to matching the capabilities
of embryonic stem cells has become a contentious question in the debate over whether the federal government should continue funding research on
embryonic lines.
«We can work with any
embryonic stem cell line from any source and are not restricted to working with the very small number
of federally approved
lines as is the case for researchers in the United States,» says Minger.
In May 2005, Hwang and his colleagues reported that it had produced 11 new human
embryonic stem (ES)
cell lines that carried the genetic signature
of patients with diabetes, spinal cord injury, or a genetic blood disorder (Science, 20 May, p. 1096).
To see whether cancer
stem cell renewal involves a chain
of events similar to that used by
embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer
cell lines that responded to low oxygen by ramping up production
of the protein ALKBH5, which removes methyl groups from mRNAs.
The laboratory process, described in the journal Scientific Reports, entails genetically modifying a
line of human
embryonic stem cells to become fluorescent upon their differentiation to retinal ganglion
cells, and then using that
cell line for development
of new differentiation methods and characterization
of the resulting
cells.
At the University
of Washington, Hannele Ruohola - Baker, professor
of biochemistry and associate director
of the Institute for
Stem Cell and Regenerative Medicine, Julie Mathieu, acting instructor and Henrik Sperber, graduate student, withdraw embryonic stem cell lines from liquid nitrogen stor
Stem Cell and Regenerative Medicine, Julie Mathieu, acting instructor and Henrik Sperber, graduate student, withdraw embryonic stem cell lines from liquid nitrogen stor
Cell and Regenerative Medicine, Julie Mathieu, acting instructor and Henrik Sperber, graduate student, withdraw
embryonic stem cell lines from liquid nitrogen stor
stem cell lines from liquid nitrogen stor
cell lines from liquid nitrogen storage.
On the other hand, the problem is, you know, with
embryonic stem cells, they haven't been able to get
stem cell lines from livestock animals that can proliferate in that way, without just sort
of veering up in their own direction and turning into, instead
of muscle, turning into brain tissue or bone tissue or something else.
Stem cell advocates have been expressing serious worry that ethical requirements spelled out in the draft guidelines — in particular, informed consent procedures for embryo donors — will rule out the use of many existing human embryonic stem cell lines, including the 21 lines approved under the Bush Administrat
Stem cell advocates have been expressing serious worry that ethical requirements spelled out in the draft guidelines — in particular, informed consent procedures for embryo donors — will rule out the use
of many existing human
embryonic stem cell lines, including the 21 lines approved under the Bush Administrat
stem cell lines, including the 21
lines approved under the Bush Administration.
The final guidelines on research with human
embryonic stem cells issued on Monday by the National Institutes
of Health set out criteria for determining which ES
cell lines can be used in federally funded experiments and give NIH discretion to approve old
lines that don't meet stringent modern ethical requirements.
In the past 3 years, the state has lured two key members
of the Victorian team that produced the world's second human
embryonic stem cell line.
«The beautiful thing,» Lanza says, «is that if you have an
embryonic stem cell line that is O negative, because it's immortal you could create an unlimited amount
of universal blood that would match virtually everybody, so you wouldn't have to worry about matching blood types.»
In 2008 a group
of medical researchers led by Robert Lanza at Advanced
Cell Technology in Worcester, Massachusetts, reported another leap: They discovered a way to avoid destroying the embryo by deriving an entire stem cell line from a single embryonic c
Cell Technology in Worcester, Massachusetts, reported another leap: They discovered a way to avoid destroying the embryo by deriving an entire
stem cell line from a single embryonic c
cell line from a single
embryonic cellcell.
While conservatives in Congress took turns echoing George W. Bush's opposition to destroying human embryos for research, Lensch's colleague Paul Lerou stepped into a small room behind a heavy black curtain to check up on a
line of nonpresidential
embryonic stem cells.
Last January, the House
of Representatives voted, 253 to 174, to pass a bill, H.R. 3, that would allow researchers to use leftover embryos from in vitro fertilization (IVF) clinics to create new
lines of embryonic stem cells, and in April, the Senate passed its version
of the bill.
They used the gene editing technology CRISPR to engineer a series
of human
embryonic stem cell lines, which were identical apart from the number
of DNA repeats that occurred at the ends
of their HTT genes.
In a statement put on the Web this morning, NIH reported that all 64
lines «show characteristics
of stem cell morphology» and have undergone several population doublings, and most
of them have demonstrated all the protein markers «known to be associated with human
embryonic stem cells.»
One is a relatively unknown company, CyThera, set up less than 2 years ago in San Diego, that claims to have nine
embryonic stem cell lines and is currently trying to develop pancreatic islet
cells for treatment
of diabetes.
In September the British Parliament funded an
embryonic -
stem -
cell bank that may eventually store thousands
of cell lines, which will help make Britain a leader in
embryonic -
stem -
cell research.
If there was one
embryonic stem cell, and it differentiated into five distinct specialized
cells, and then these specialized
cells were reprogrammed into five distinct induced
stem cell sets — then at least one
of these
lines would be similar to an
embryonic cell with 95 % confidence.
In August
of last year, President George W. Bush announced that scientists who received public research money could use only the human
embryonic stem -
cell lines that already exist — a decision that dismayed many researchers.
Salk scientists and colleagues have proposed new molecular criteria for judging just how close any
line of laboratory - generated
stem cells comes to mimicking
embryonic cells seen in the very earliest stages
of human development, known as naïve
stem cells.
But last April he also voted for the HOPEAct, a Bush - supported «compromise» bill that would open up federal funding for research that does not involve the creation, destruction, or injury
of embryos; seeing as there are not yet any
embryonic stem cells lines that meet this condition (ACT hasn't yet proven that their technique poses no «risk
of injury»), the HOPE funding would only be available for non-
embryonic stemcells.
This Korean researcher racked up a series
of important advances in
embryonic stem cell technology, including the first
lines of cells from patients
The only
stem cell research he would permit, Bush said, was research using existing
embryonic lines as well as so - called adult
stem cells, which occur in anyone
of any age.
In other cases, the goal was to establish a
line of embryonic stem cells.
The long - awaited registry
of human
embryonic stem cell lines approved by the National Institutes
of Health (NIH) went up on the Web this week.
Attempting to find middle ground in the contentious debate over human
embryonic stem cells, President George W. Bush announced 9 August that the National Institutes
of Health (NIH) will be allowed to fund work with
embryonic stem (ES)
cell lines — but only those
lines that have already been derived.
A bill that would allow federal funding for derivation
of new
lines of human
embryonic stem (ES)
cells passed the U.S. House
of Representatives yesterday 238 to 194 after more than four hours
of debate.
According to a new analysis, the
cell line they created represented the first example
of parthenogenetic human
embryonic stem (ES)
cells.
During the next five years, KOMP2 will transform the knockout mouse
embryonic stem (ES)
cells into adult mice for 2,500
lines of well - characterized knockout mice strains, and IMPC will create about 2,500 additional knockout mouse strains.
Twenty - seven human
embryonic stem cell (hESC)
lines are ethically derived and should be approved for use in research funded by the US linkurl: National Institutes
of Health; http://www.nih.gov/ (NIH), a committee advising the NIH director linkurl: recommended today (December 4).
His executive order allowed funding on
embryonic stem -
cell lines derived from embryos that had already been destroyed, but excluded funding
of research using
stem cells from embryos destroyed after August 9, 2001 (the date
of his announced policy).
The goal
of this protocol (written in French) is to describe the steps and quality controls to prepare new stable murine
embryonic stem cells lines: ① either from wild type mouse embryos to introduce a mutation by genetic targeting or homologous recombination to get a genetically modified mouse
line ② or from genetically modified mouse embryos with two aims:
Establishment
of a human
embryonic germ
cell line and comparison with mouse and human
embryonic stem cells.
KOMP2 and IMPC researchers will begin by creating
lines of knockout mice from
embryonic stem cells produced by KOMP.