The major discovery
of embryonic stem cells by Martin Evans in 1981 has indeed been recognized by a Lasker and other awards.
Cardiac differentiation
of embryonic stem cells by substrate immobilization of insulin - like growth factor binding protein 4 with elastin - like polypeptides.
The isolation
of embryonic stem cells by Dr. James Thomson in 1998 put the issue of stem cell research on the map.
Not exact matches
One can not help but be intrigued
by the implications
of the fact that these adult
stem cells can be induced to «reprogram» themselves back to their beginning — all the way back to their
embryonic beginning.
While the entity generated
by deleting or disabling early
embryonic genes would produce only an unorganized collection
of stem cells, it would do so after a period
of what appears to be relatively normal development.
Attempts have been made to bridge this divide
by proposing alternative sources
of embryonic stem cells for research and therapeutic purposes.
Embryonic stem cells are produced during development
by the same process
of epigenetic programming that later will produce adult
cells such as skin and brain.
Such a single - step conversion
of an adult
cell into an
embryonic stem cell entirely avoids the question
of whether an embryo has been created, since the
cell produced
by ANT - OAR never exhibits any
of the properties
of a single -
cell embryo.
Let us be thankful that a tool for discrediting the pro-life movement (shaming us for opposing magical cures promised
by embryonic stem -
cell research) has itself been taken out
of their hands.
Sullivan went on to suggest that Chaput is using a double standard in the 2008 election
by criticizing Catholic supporters
of Barack Obama, while turning a blind eye to John McCain's support for
embryonic stem cell research.
In our day it has been thrust into the realm
of immediate urgency
by advances in
embryonic stem cell and cloning technologies.
This question has been the topic
of considerable legal and social debate over the years since the Supreme Court's Roe v. Wade decision» debate that has only been intensified
by the recent controversies over human
embryonic stem cells and human....
He decreed that the case brought
by researchers Drs James Sherley and Theresa Deisher, along with a number
of Christian groups including the Christian Medical Association, should be heard; and ordered an injunction temporarily blocking federal funding allocated for human -
embryonic -
stem -
cell research.
Embryonic stem cell research has the potential to save millions
of lives, but this is being prevented
by religious radicals and therefore religion is detrimental to the preservation
of life.
One
of the best talks
of this conference was given
by Dr. Renee Reijo Pera, Professor and Director
of the Center for Human
Embryonic Stem Cell Research at Stanford University.
Furthermore,
by making use
of embryonic stem cells and in vitro differentiation, SIF - seq can be used to assess enhancer activity in a wide variety
of disease - relevant
cell types.»
Some scientists had claimed that the lymphatic system was derived from specialized
stem cells called angioblasts, whereas others had argued that it originated
by the differentiation
of pre-existing
embryonic veins.
Faced with an often - hostile Congress, Obama enacted many
of his signature policies
by executive order — from reversing restrictions on research with human
embryonic stem cells to helping communities prepare for climate change.
The scientists rescued the microcephaly during mouse
embryonic development
by removing a protein that caused the loss
of stem cells.
By analysing the early steps that precede tumor formation, Alexandra Van Keymeulen and colleagues found that expression
of oncogenic Pik3ca reactivates a multilineage differentiation program in adult
stem cells that resembles to an immature
embryonic state.
Oliver Brüstle, director
of the Institute
of Reconstructive Neurobiology at the University
of Bonn, Germany, who had a patent on a method for generating neurons from human
embryonic stem cells rejected
by the court, called the ruling «the worst possible outcome», and «a disaster for Europe».
The latest findings show that genetic defects in the body's ability to manufacture carnitine might be associated with an increased risk
of autism because carnitine deficiency interferes with the normal processes
by which neural
stem cells promote and organize
embryonic and fetal brain development.
Some
of the researchers at the centre will study the differentiation
of stem cells into other
cell types, one group
by using human
embryonic stem cell biology and another
by studying early embryo development.
Stephen Minger, director
of the
Stem Cell Biology Laboratory at King's College London, UK, says he is «intrigued»
by the claims but would like to see more proof
of the
cells»
embryonic character.
They then argue that «
By creating a financial incentive for embryonic stem cell research — an incentive that by NIH's own admission involves investments of «hundreds of millions of dollars» — and by specifying the precise means by which embryos must be destroyed in order to qualify for federal funding, the NIH necessarily and knowingly subjects embryos to a substantial risk of injury or death.&raqu
By creating a financial incentive for
embryonic stem cell research — an incentive that
by NIH's own admission involves investments of «hundreds of millions of dollars» — and by specifying the precise means by which embryos must be destroyed in order to qualify for federal funding, the NIH necessarily and knowingly subjects embryos to a substantial risk of injury or death.&raqu
by NIH's own admission involves investments
of «hundreds
of millions
of dollars» — and
by specifying the precise means by which embryos must be destroyed in order to qualify for federal funding, the NIH necessarily and knowingly subjects embryos to a substantial risk of injury or death.&raqu
by specifying the precise means
by which embryos must be destroyed in order to qualify for federal funding, the NIH necessarily and knowingly subjects embryos to a substantial risk of injury or death.&raqu
by which embryos must be destroyed in order to qualify for federal funding, the NIH necessarily and knowingly subjects embryos to a substantial risk
of injury or death.»
They also showed that the
cells have most
of the surface «markers» considered as identifiers
of embryonic stem cells and form «embryoid bodies» — characteristic clumps
of cells formed
by ESCs.
Then, a team led
by Robert Lanza, the chief scientific officer
of Advanced
Cell Technology Inc. in Marlborough, Massachusetts, and his colleagues published the first results ever
of a clinical trial using human
embryonic stem cells.
The only previous demonstration —
by researchers led
by Shou - Wei Ding, PhD, a professor
of Plant Pathology and Microbiology at UC Riverside and co-corresponding author
of the current study — was done in
embryonic stem cells and in newborn mice.
To see whether cancer
stem cell renewal involves a chain
of events similar to that used
by embryonic stem cells, and whether the process was affected
by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer
cell lines that responded to low oxygen
by ramping up production
of the protein ALKBH5, which removes methyl groups from mRNAs.
In collaboration with Ding, the lab
of Olivier Voinnet at the Swiss Federal Institute
of Technology in Zurich also reported in an accompanying paper the detection
of viral siRNAs in cultured mouse
embryonic stem cells infected
by the Encephalomyocarditis virus.
Studies
of embryonic stem cells revealed that NANOG protein levels can be lowered
by a chemical process known as methylation, which involves putting a methyl group chemical tag on a protein's messenger RNA (mRNA) precursor.
Research on
embryonic stem cells funded
by the U.S. government must stop immediately for a court - ordered review, Judge Royce Lamberth
of the U.S. District Court for the District
of Columbia ruled today.
For the purpose
of additional experiments, the researchers generated myocardial
cells from
embryonic stem cells and human skin
cells, in collaboration with the lab headed
by Prof Dr Jürgen Hescheler at the University
of Cologne.
Newcastle University and the NorthEast England
Stem Cell Institute are aware that the research paper «Derivation
of Human Sperm from
Embryonic Stem Cells»
by a group led
by Professor Karim Nayernia has been withdrawn from the academic journal
Stem Cells and Development.
The final guidelines on research with human
embryonic stem cells issued on Monday
by the National Institutes
of Health set out criteria for determining which ES
cell lines can be used in federally funded experiments and give NIH discretion to approve old lines that don't meet stringent modern ethical requirements.
Lamberth granted a preliminary injunction on this research after hearing a petition from a group
of advocates who argued that, contrary to the U.S. government's view, research on
embryonic stem cells does in fact destroy embryos — action that is prohibited
by legislation known as the «Dickey - Wicker Amendment» to the bill that funds the Department
of Health and Human Services.
The results help fill in the scientific puzzle kicked off
by Dolly's cloning, which proved that mammalian egg
cells were capable
of dissolving the genetic roadblocks that limit the potential
of most adult
cells to give rise to only a single type
of tissue — that
of the organ from which they hail — whereas
embryonic stem cells have the potential to become virtually any kind
of body tissue.
In 2008 a group
of medical researchers led
by Robert Lanza at Advanced
Cell Technology in Worcester, Massachusetts, reported another leap: They discovered a way to avoid destroying the embryo by deriving an entire stem cell line from a single embryonic c
Cell Technology in Worcester, Massachusetts, reported another leap: They discovered a way to avoid destroying the embryo
by deriving an entire
stem cell line from a single embryonic c
cell line from a single
embryonic cellcell.
They are easier than
embryonic stem cells to come
by and they match the genetic background
of the person from whom they were obtained.
• A team led
by Ron McKay at the National Institute
of Neurological Disorders and Stroke in Bethesda, Maryland, turned mouse
embryonic stem cells into isletlike
cells, another step down the long road to a cure for diabetes.
Mouse
embryonic stem cells, reported in 1981
by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains
of mice that have revolutionized studies
of organismic development and immunity and have provided countless models
of human disease.
The ethics council finally issued its 20 - page report just before Christmas, voting in favor
of allowing the import
of human
embryonic stem cells, under certain conditions,
by a small majority
of 15 to 9, paving the way for next week's final showdown.
The researchers confirmed Olig2's role in promoting motor neuron formation
by increasing or blocking the function
of Olig2 in the spinal cords
of developing mouse and chicken embryos, as well as during motor neuron formation in mouse
embryonic stem cells.
Scientists were even more stunned in July 2002 when researchers led
by stem cell biologist Catherine Verfaillie at the University
of Minnesota reported that bone marrow — derived
cells they had injected into young embryos contributed to all three
embryonic layers, just as
embryonic stem cells would do.
Eva Mezey, a
stem cell biologist at the National Institutes
of Health who published one
of the transdifferentiation studies and stands
by the effect, notes that
embryonic cells are naturally more versatile than adult
stem cells.
The National Institutes
of Health (NIH) pleased
stem cell watchers today
by announcing the names
of 10 companies and research groups that have human
embryonic stem cells federally funded researchers can use.
Not only do many
of the ethical challenges posed
by embryonic stem cells remain, but the relative ease and low cost
of iPS techniques, combined with the accessibility
of cells, accelerate the need to address futuristic - sounding possibilities such as creating gametes for reproduction.
This discovery
by the scientists at the CRG provides an insight into
stem cell - forming molecular mechanisms, and is therefore
of great interest for studies on the early stages
of life, during
embryonic development.
This year, a team led
by the Hebrew University
of Jerusalem finally produced haploid human
embryonic stem cells by forcing unfertilized egg
cells to divide.
In his January 2008 State
of the Union address, President George W. Bush claimed that research
by James Thomson
of the University
of Wisconsin and Shinya Yamanaka
of the University
of Kyoto in Japan would finally end the morally and politically nettlesome debate over
embryonic stem cell research.