While the report claims to find
evidence of endocrine disruption by some chemicals in wildlife, its authors conclude there is insufficient evidence to establish that endocrine disrupting chemicals have produced effects in humans.
But some of the impacts — such as the reduction in number of «heat» cycles for the females — are «hormonally driven,» raising
suspicion of endocrine disruption, she said.
While this wealth of knowledge was piling up, EPA, held back by institutional inertia, continued to attempt to validate a handful of single - focus assays to detect only a very small
component of endocrine disruption.
Although underlying
mechanisms of endocrine disruption through chemicals in humans are still unclear, the peroxisome proliferator - activated receptors (PPARs) and reactive oxygen species are yet suspected to play a major role (183).
A study on rabbits found that after exposure to dibutyl phthalate, rabbits exhibited
symptoms of endocrine disruption including reduced testicle size, reduced sperm counts and reduced testosterone levels.
Synthetic sunscreens, like oxybenzone, because it accumulates in the body and has been cited as a cause of endocrine disruption
Bisphenol - A and the great divide: A review of controversies in the field of endocrine disruption
Newbold primarily looked at the effects of the synthetic estrogen DES on the development and growth of rats; but she also examined other
sources of endocrine disruption, including the phytoestrogens genistein and diadzen in soy.