«The idea is that as animals grow old, similar to in humans, the activity
of the endogenous cannabinoid system goes down — and that coincides with signs of aging in the brain,» Zimmer says.
More recently, Dr. Parsons has explored the involvement
of endogenous cannabinoid signaling in the rewarding effects of abused drugs.
We are also exploring the role
of the endogenous cannabinoid (endocannabinoid) system in fetal brain development and investigating how prenatal cannabis exposure affects brain development and later behaviors.
Not exact matches
The main difference between
endogenous cannabinoids and opioids, Felder explains, is that
cannabinoids are part
of the fat family, which also distinguishes them from other neurotransmitters.
Dr. Parsons gave many invited presentations at professional meetings and universities abroad, including a 2009 invited lecture in Jerusalem in a symposium that featured and honored Dr. Raphael Mechoulam, who is known for the initial identification and characterization
of Δ9 - tetrahydrocannabinol (the main active constituent in cannabis) and the
endogenous cannabinoids anandamide and 2 - arachidonoyl glycerol (2 - AG).
Twenty - eight years after discovering THC, in 1992, Dr. Mechoulam, along with Dr. William Devane and Dr. Lumir Hanus, identified the brain's first
endogenous cannabinoid (or endocannabinoid)-- the brain's natural version
of THC — which they named «anandamide,» from the Sanskrit word «ananda,» which means «eternal bliss» or «supreme joy.»
These
endogenous cannabinoids are a part
of a system that acts as the «master control»
of the body.
«CBD interacts with the body through the
endogenous cannabinoid system (ECS) which is the part
of the body that regulates the body's homeostasis or general state
of balance, which impacts integral functions
of the body such as mood, sleep, hormone regulation and pain / immune response,» says Madeleine Murphy, whose Brooklyn cafe sells a CBD - infused hot chocolate.
First, by interacting with CB1 receptors, the
endogenous cannabinoids released will help inhibit the firing
of cAMP into succeeding neurons.