Sentences with phrase «of endoplasmic reticulum stress»

In fact, genetic and pharmacological targeting of the IRE - 1 / XBP - 1 pathway of the endoplasmic reticulum stress response, which is critical for antibody production, results in decreased numbers and reduced functions of MDSCs.

Bottom: Human epithelial cells from breast tissue showing the effects of endoplasmic reticulum stress (blue) which fills the entire cell structure.

Not exact matches

When it reaches the brain, Zika virus infects neuronal stem cells, which will generate fewer neurons, and by inducing chronic stress in the endoplasmic reticulum, it promotes apoptosis, i.e. the early death of these neuronal cells.

They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).

Fat - induced stress and metabolic overload of the endoplasmic reticulum can alter its function, triggering chronic inflammation, which plays an important role in the development of atherosclerosis.

The researchers also examined BRAF mutant melanoma cell lines, and found that BRAF inhibition induced autophagy by way of an endoplasmic reticulum (ER) stress response.

It turns out that neuropathic pain is triggered when the body experiences endoplasmic reticulum (ER) stress, a condition in which the production and transport of protein exceeds the cells» capacities, say researchers from the University of California, Davis.

The findings reveal a causal chain of events whereby the decreased levels of wolframin protein destabilize the endoplasmic reticulum (causing endoplasmic reticulum stress), thereby reducing calcium release.

Specifically, under stress, caused by uncontrolled ingestion of fats for example, the endoplasmic reticulum — a cell organelle associated with protein synthesis and folding and lipid metabolism — stops its activity in order to re-establish cell equilibrium.

Lung fibrosis is thought to also come about when the endoplasmic reticulum (ER) in the cells of the lung becomes stressed and can no longer properly fold and unfold proteins.

Role of endoplasmic reticulum calcium stores in beta - cell ER stress and lipotoxicity.

Based on the study of the RB51 - macrophage interaction model, endoplasmic reticulum stress activates the inflammasome via NLRP3 - and caspase -2-driven mitochondrial damage (Bronner et al, 2015).

Endoplasmic Reticulum Stress Plays a Key Role in the Pathogenesis of Diabetic Peripheral Neuropathy.

Target of rapamycin signaling mediates vacuolar fission caused by endoplasmic reticulum stress in Saccharomyces cerevisiae.

Targeting of the c - Abl tyrosine kinase to mitochondria in endoplasmic reticulum stress - induced apoptosis.

Mu Y - ping, Ogawa T, Kawada N. Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine - choline - deficient diet.

The selective destruction of acinar cells by high dose of L - arginine may be partly attributed to disruption of protein metabolism, increased oxidative stress, and endoplasmic reticulum stress [6].

Current studies have demonstrated that the chronic endoplasmic reticulum stress and oxidative stress play an important role in development and progression of AP [4, 5].

He investigates endoplasmic reticulum - associated stress signaling molecules, which play important roles in the quality control of secretory and integral membrane proteins.

Cytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum - 2006 International Journal of Molecular Medicine.

An alternate mechanism through which alcohol may limit rates of protein synthesis is endoplasmic reticulum stress and the resultant unfolded protein response.

Alcohol consumption generates oxidative stress and inflammation and the potential to disrupt endoplasmic reticulum homeostasis; a consequence of this response is to limit the rate of protein synthesis [44], [45].