Sentences with phrase «of endothelial dysfunction»

They also measured an extensive array of biomarkers of both endothelial dysfunction (such as von Willebrand factor) and low - grade inflammation (including C - reactive protein and serum amyloid A).

Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy.

The absence of sufficient dissolved nitric oxide (NO) is the cause of endothelial dysfunction.

In 2010 a study confirmed that in the early stages of menopause women have higher risks of endothelial dysfunction.

Multivariate - adjusted geometric means of markers of endothelial dysfunction across quintile (Q) categories of partially hydrogenated vegetable oils (PHVOs) and non-hydrogenated vegetable oils (non-HVOs) 1

Hypothyroidism is associated with signs of endothelial dysfunction despite 1 - year replacement therapy with levothyroxine.

Elevated plasma concentrations of soluble forms of endothelial adhesion molecules, released from shedding or proteolytic cleavage from the endothelial cell surface, are considered useful indicators of endothelial dysfunction and activation (20, 25).

In the present analysis, we also assessed the correlations between magnesium intake and the concentrations of 3 endothelial adhesion molecules, which are up - regulated in the early cascade of endothelial dysfunction.

Impaired penile microcirculation may serve as an early marker of endothelial dysfunction, indicating higher cardiovascular risk.

They suggested that the telomere G - tail might be a useful marker of endothelial dysfunction, as well as stroke and dementia.

Not exact matches

Endothelial dysfunction (low blood vessel reactivity) is considered an early indicator of cardiovascular disease risk.

This impaired responsiveness due to caffeine is worrisome, Aznaouridis notes, since «endothelial dysfunction is a precursor of atherosclerosis.»

We also demonstrate that NS1 from DENV1, DENV2, DENV3, and DENV4 triggers endothelial barrier dysfunction, causing increased permeability of human endothelial cell monolayers in vitro.

Therefore, the primary novelty of the discoveries reported here is that programming by prenatal chronic hypoxia of cardiac and vascular dysfunction in adulthood follows the induction of oxidative stress in the fetal heart and vasculature, and that cardiac and endothelial dysfunction in adulthood can both be prevented by maternal treatment with antioxidants during pregnancy.

It is interesting that the balance of redox modulation of vascular tone, imposed by the O2 • −: NO ratio, may be tipped in either direction to promote disequilibrium, as maternal treatment with vitamin C in normoxic pregnancy also promoted endothelial dysfunction.

Here, we tested the hypothesis that oxidative stress in the fetal heart and vasculature underlies the molecular basis through which prenatal hypoxia contributes to the developmental programming of cardiac and endothelial dysfunction.

Role of the endothelial - derived endogenous anti-inflammatory factor Del - 1 in inflammation - mediated adrenal gland dysfunction.

Protein nitrotyrosine is a marker for inflammatory or oxidative stress processes (characteristic of COPD) and may also indicate endothelial dysfunction (systemic malfunctioning of the inner lining of blood vessels), a common cause of cardiovascular disease.

Further studies present an association in women between the stress level and the activation of the vascular endothelial nitric oxide (NO) system, as well as with the carotid intima media thickness, suggesting a close link to stress induced cardiovascular dysfunction in women (99).

Research Interests: One - carbon metabolism; methionine cycle; transsulfuration; micronutrients; vitamin B12 (cobalamins); folates; homocysteine; homocystinuria; hyperhomocysteinemia; diagnosis of cobalamin deficiency; atherogenesis; endothelial cell dysfunction; alcoholic liver disease; biomarkers of one - carbon metabolism.

The results suggest that effective therapeutic agents could be developed to enhance the effects of GLP - 1R on the endothelium which may prevent glomerular endothelial dysfunction and slow the progression of diabetic nephropathy.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Edward Bullmore, UK Robert Dow, UK Garrett Fitzgerald, USA - Prostanoid biology and the role of peripheral molecular clocks in cardiovascular biology, metabolism and aging Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Patrick du Souich, Canada - Cytochrome P450, membrane carriers, disease, inflammation, rational use of drugs, clinical pharmacology David J. Webb, UK - hypertension, chronic kidney disease, endothelial function and dysfunction, arterial stiffness, health technology assessment, medicines regulation Don Birkett, Australia - Clinical pharmacology / pharmacokinetics and drug utilisation

Sep. 13, 2016 — High levels of blood markers for vascular endothelial dysfunction were associated with longer periods of confusion in ICU patients, Vanderbilt researchers have discovered.

Endothelial dysfunction has been shown to be closely related to insulin resistance (20, 24) and to precede the onset of early atherosclerotic CVD and type 2 diabetes (25).

Plasma concentrations of biomarkers of inflammation and endothelial dysfunction by quintile (Q) of dietary magnesium intake in 657 apparently healthy women in the Nurses» Health Study1

Early endothelial dysfunction can readily be assessed by measuring circulating concentrations of endothelial soluble adhesion molecules.

It seems likely that the observed associations between magnesium intake and markers of inflammation and endothelial dysfunction may, at least in part, reflect the direct effect of magnesium intake on glucose and insulin homeostasis.

Recognition is growing that, because they are common antecedents for the initiation of atherosclerosis and type 2 diabetes, systemic inflammation and endothelial dysfunction may be 2 integral components of the metabolic syndrome, (19, 20).

Both the egg group and sausage and cheese group caused endothelial dysfunction, a sign of inflammation.

Its going to be a short interventional study looking at the inflammatory effects of 1 meal + endothelial dysfunction but it will be very enlightening nonetheless.

Conclusions: These findings suggest that a single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone is effective for improving postprandial endothelial dysfunction.

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension.

Effect of a Mediterranean - style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial

Ahmad Esmaillzadeh, Leila Azadbakht; Home use of vegetable oils, markers of systemic inflammation, and endothelial dysfunction among women, The American Journal of Clinical Nutrition, Volume 88, Issue 4, 1 October 2008, Pages 913 — 921, https://doi.org/10.1093/ajcn/88.4.913

These nutritional markers provide a thorough assessment of cardiovascular health status, revealing the biochemical environment associated with inflammation, lipid deposits, endothelial dysfunction, and clotting factors underlying cardiovascular disease.

Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women.

This comes in the wake of over a decade worth of research showing that chocolate and / or cocoa lowers blood pressure, prevents or ameliorates endothelial dysfunction (a primary contributor to atherosclerosis), protects against coronary artery disease, reduces stroke risk, prevents cholesterol oxidation (which converts healthy lipoproteins into artherogenic ones), to name only 5 of 70 + potential health benefits associated with its regular consumption.

A diet including healthy foods, plenty of fish, and increased EPA and DHA, research shows, could reduce inflammation and decrease endothelial dysfunction.

In conclusion, alpha - lipoic acid may reduce the risk of vascular endothelial dysfunction.

High homocysteine levels can result in endothelial dysfunction (a narrowing of the arteries) which in turn is believed to be a precursor of atherosclerosis.

As a general maintenance dose, the authors of the study suggested individuals take a 500 mg, or more, daily dose of vitamin C during periods of stress, deficiencies, or anyone dealing with endothelial dysfunction.

Further analyses indicated that consumption of more lean fish and raw vegetables and fewer high - fat dairy products was associated with less endothelial dysfunction.

«Endothelial dysfunction and low - grade inflammation play important roles in the development of CVD,» the investigators wrote in their December 31 online paper in The Journal of Nutrition.

Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction

We will continue to explore Chrysalin's therapeutic value in tissues and diseases exhibiting endothelial dysfunction as well as the science behind and potential of Chrysalin.