Sentences with phrase «of endothelin»

Short - term hemodynamic effects of endothelin receptor blockade in dogs with chronic heart failure

-- We have shown that the genetic change causing fibromelanosis is a complex rearrangement that leads to increased expression of Endothelin 3, a gene which is known for promoting the growth of pigment cells, explains Ben Dorshorst the post-doctoral researcher responsible for the work.

But the team determined that the SNP, called rs9349379, actually regulates the expression of a different gene upstream: EDN1, which codes for a precursor of the endothelin - 1 protein.

Higher levels of endothelin - 1 can cause the arteries to harden, suggesting a mechanism of action for rs9349379 to increase risk for certain vascular disorders.

The presence of a guanine nucleotide at rs9349379 was associated with higher levels of the endothelin - 1 precursor protein produced by EDN1, as well as higher rates of coronary artery disease and lower rates of migraine headache, cervical artery dissection, fibromuscular dysplasia, and hypertension.

Knockout of endothelin type B receptor signaling attenuates bleomycin - induced skin sclerosis in mice.

Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of endothelin - 1

Gender differences in the expression of endothelin receptors in human saphenous veins in vitro

«The biggest value of this work is the pinpointing of endothelin - 1 as a core gene for multiple vascular diseases.»

«The main value of our research is the pinpointing of the importance of endothelin - 1 and blood vessel constriction to multiple vascular diseases,» says senior author Sekar Kathiresan, a cardiologist at the Broad Institute of MIT and Harvard University.

It combines some of the actions of ARBs with those that reduce the effects of endothelins, compounds that increase blood pressure.

Not exact matches

In the journal Cell on July 27, researchers show how this DNA variant enhances the activity of a gene called endothelin - 1 (EDN1), which is known to promote vasoconstriction and hardening of the arteries.

In an accompanying editorial, Kiran Chandrashekar, MD and Luis Juncos, MD (University of Mississippi) noted that there is a critical need to develop additional therapies to improve the treatment of diabetic nephropathy and that endothelin inhibitors hold considerable promise.

Stimulation of Transforming Growth Factor - ß1 - Induced Endothelial - To - Mesenchymal Transition and Tissue Fibrosis by Endothelin - 1 (ET - 1): A Novel Profibrotic Effect of ET - 1.

Mechanisms behind the consequences of castration resulting in endogenous androgen withdrawal were explained by effects on NO production, which is higher if testosterone is absent, and the endothelin B receptor, which may be directly influenced by testosterone and causes vasoconstriction.

Additional confirmation was given by another animal study showing more negative effects of androgens on glycemic control, BP, and endothelial and vascular response to endothelin - 1, thromboxane or NO (327).

One of the factors now implicated in glaucoma - associated neurodegeneration is the endothelin (EDN) system, but the mechanisms are not yet known.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Magnesium - deficiency elevates circulating levels of inflammatory cytokines and endothelin

, Thyme extract, but not thymol, inhibits endothelin - induced contractions of isolated rat trachea, 2008

A recent study found that older individuals have up to 130 percent more endothelin - 1 in their blood than do younger people.8 That suggests that in the elderly, insulin may not be able to overcome elevated levels of the powerful vasoconstrictor ET - 1.

Her research interests during her residency included novel therapies for the treatment of canine pulmonary hypertension (endothelin) antagonists as well as echocardiographic evaluation of the heart's «pump» function in the setting of mitral valve disease.