Sentences with phrase «of epidermal»

Speaker: Dr. Dorothy Supp Title: The role of epidermal keratinocytes in keloid scarring.

Now that I've realized the error of my ways, I've repented of my epidermal sins and turned my back on my sun worshipping ways.

The levels of omega 6: omega 3 are critical for the development and regulation of epidermal barrier integrity and sebum formation.

With that, we can expect to see a steady decline of epidermal collagen (this makes up about 80 % of of the protein in your skin).

In support of this threshold effect, doubling or tripling peel - 1 copy number among male - sired embryos did not produce a more severe phenotype, at least as measured by the onset of epidermal leakage (Figure 5D).

To measure the onset of epidermal leakage in peel -1-affected embryos, pre-arrest embryos were dissected from the following crosses.

During wound healing differentiated Gata6 (+) cells migrate from the SD into the interfollicular epidermis and dedifferentiate, acquiring the ability to undergo long - term self - renewal and differentiate into a much wider range of epidermal lineages than in undamaged tissue.

The cells are held close to the base of the epidermal derived cells that produce the hair fiber and root sheaths but there is a thin layer, called the basement membrane (or basement lamina, or glassy membrane) that separates the DP cells from the hair fiber / sheath cells.

Morphologically, the DZ in the wild type (WT) is marked by the appearance of epidermal root hairs on the external surface of outer cell files (trichoblast) and the existence of fully differentiated xylem for internal cell files (Dolan et al, 1993; Ishikawa & Evans, 1995; Beemster et al, 2003; Verbelen et al, 2006; Zhang et al, 2010; Mähönen et al, 2014).

Along the same lines, in non-small cell lung cancer (NSCLC), acquired resistance to Gefitinib / Erlotinib kinase inhibitors has also been associated with a secondary mutation of the gatekeeper Thr790 residue of the epidermal growth factor receptor (EGFR).

His graduate work at Yale University involved making lots of mutations in the transmembrane region of the epidermal growth factor receptor (EGFR) and collecting data on which mutations affected dimerization.

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.

Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy - refractory, advanced colorectal cancer.

Urokinase - type plasminogen activator receptor regulates a novel pathway of fibronectin matrix assembly requiring Src - dependent transactivation of epidermal growth factor receptor.

Ng explains, «The two - step bioprinting strategy involves the fabrication of hierarchical porous collagen - based structures (that closely resembles the skin's dermal region), and deposition of epidermal cells such as keratinocytes and melanocytes at pre-defined positions on top of the biomimetic dermal skin constructs, to create 3D in - vitro pigmented human skin constructs.

In addition to causing proteins to be secreted through general pathways from the cell and pathways involving metalloproteases, PMA specifically causes activation of an epidermal growth factor receptor (EGFR).

Multiple mechanisms collectively regulate clathrin - mediated endocytosis of the epidermal growth factor receptor.

RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis.

Basic fibroblast growth factor reduces scar by inhibiting the differentiation of epidermal stem cells to myofibroblasts via the Notch1 / Jagged1 pathway.

However, its use is hampered by the difficulty in supplying the amount of epidermal substitute needed in order to extend the application to all patients who may benefit from it.

Changes in cell junctions induced by inhibition of epidermal growth factor receptor in oral squamous cell carcinoma cells.

The discovery of the shape and binding capability of epidermal cells could explain how skin maintains a barrier even when it is shedding.

The researchers suggest that a shape of an epidermal cell is actually a flattened version of a tetrakaidecahedron — a 14 - sided 3D solid made out of six rectangular and eight hexagonal sides.

In other cases, fails in the interlocking barrier between cells — the tight junctions — may partly explain why in psoriasis there is an overproduction of epidermal cells, causing thick patches of skin on the surface.

Now, a team from Keio University in Japan, working with a researcher at Imperial College London, have discovered that the shape of the epidermal cells combined with their ability to temporarily glue together, may explain how they form this strong barrier.

One of the key metabolic alterations that takes place during EMT is that of the epidermal growth factor receptor (EGFR) which is a pathway that regulates growth, survival, proliferation, and differentiation in mammalian cells.

Wei Long Ng explained: «The two - step bioprinting strategy involves the fabrication of hierarchical porous collagen - based structures (that closely resembles the skin's dermal region), and deposition of epidermal cells such as keratinocytes and melanocytes at pre-defined positions on top of the biomimetic dermal skin constructs, to create 3D in - vitro pigmented human skin constructs.

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

A comparison of epidermal equivalents generated from iPSC, hESC and primary human keratinocytes (skin cells) from skin biopsies showed no significant difference in their structural or functional properties compared with the outermost layer of normal human skin.

This keeps a portion of the incoming light from reaching the starch layer, ensuring that it is reflected in a directional manner by the flat cells at the base of the epidermal layer.

The key to the buttercup's glow seems to lie in the exceptionally flat cells of its epidermal layer.

About 15 to 20 % of breast cancers are classified as «triple negative,» so called because these tumors do not express three key proteins that are biomarkers and / or drug targets for breast cancer: the estrogen receptor, the progesterone receptor, and HER2 (a member of the epidermal growth factor receptor family).

HPV is an infection of epidermal tissue, so infection only requires skin to skin contact.

Right after childbirth, the colostrum contains high amounts of epidermal growth factor.

Not exact matches

Increased epidermal growth factor levels in human milk of mothers with extremely premature infants.

Findings of the research, published April 22 in the journal Mucosal Immunology, reveal that a substance found in animal and human breast milk called epidermal growth factor, or EGF, blocks the activation of a protein responsible for unlocking the damaging immune cascade that culminates in NEC, a disease marked by the swift and irreversible death of intestinal tissue that remains one of the most - challenging - to - treat conditions.

Our patented NIA - 114 ™ helps to increase skin firmness, diminish trans - epidermal water loss, and reduce the appearance of sagging over time.

High total and saturated fat intake were associated with greater risk of estrogen receptor - and progesterone receptor - positive (ER+PR +) breast cancer (BC), and human epidermal growth factor 2 receptor - negative (HER2 --RRB- disease, according to a new study published April 9 in the Journal of the National Cancer Institute.

Clinically important findings suggest that targeting the epidermal growth factor receptor (EGFR) and the fibroblast growth factor receptor (FGFR) cellular pathways may benefit thousands of patients with this disease, according to the study published today in the journal PLOS Genetics.

Interestingly, they found that stem cells coming from different epidermal compartments present very similar response during wound repair, despite the fact that they are recruited from different regions of the epidermis.

Between 10 and 30 percent of NSCLC cases are driven by mutations in the epidermal growth factor receptor (EGFR) gene.

Researchers found that a combination of drugs — one targeting epidermal growth factor receptor (EGFR) and one targeting tumor necrosis factor (TNF)-- effectively blocks the cancer from using TNF as an escape route.

The grafts that best approximate the look and feel of a face are «full - thickness» grafts, which involve harvesting the outer (epidermal) layer of skin along with the underlying (dermal) layers from elsewhere on the body.

Francesco Greco, materials scientist at the Institute of Solid State Physics of TU Graz explains: «With this method we have managed to take a big step forward in further developing epidermal electronics.

By using a range of tissue stains, they were able to assess levels of oestrogen receptor (ER), progesterone receptor (PR) and HER2 — human epidermal growth factor — in order to divide the samples into four subtypes.

Ullrich Steiner, at the University of Cambridge, and colleagues separated the layers that make up buttercup petals — an inner layer of starch and an outer epidermal layer that holds the yellow pigment — and shone light onto each.

«CRKII most likely regulates the stability of mutated epidermal growth factor receptors and drives cancer growth by promoting signaling, or communication, within cancer cells,» said Julia Petschnigg, lead author on the paper and a postdoctoral fellow at U of T. «We found that a combinatorial chemotherapy that inhibits those mutated receptors and CRKII could be beneficial in treating lung cancer.»

Potential adverse side effects include toxicity of the nervous system, kidney and liver, headaches, and rare, but serious skin conditions such as Stevens Johnson syndrome and toxic epidermal necrolysis.

Importantly, the new technique grows the pluripotent stem cells as floating spheres in high concentrations of two growth factors, fibroblast growth factor - 2 and epidermal growth factor.

«We also need to establish the role of the host epidermal cells that the dermal papilla cells interact with, to make the new structures.»