Sentences with phrase «of epidermal cells»

Ng explains, «The two - step bioprinting strategy involves the fabrication of hierarchical porous collagen - based structures (that closely resembles the skin's dermal region), and deposition of epidermal cells such as keratinocytes and melanocytes at pre-defined positions on top of the biomimetic dermal skin constructs, to create 3D in - vitro pigmented human skin constructs.

The discovery of the shape and binding capability of epidermal cells could explain how skin maintains a barrier even when it is shedding.

In other cases, fails in the interlocking barrier between cells — the tight junctions — may partly explain why in psoriasis there is an overproduction of epidermal cells, causing thick patches of skin on the surface.

Now, a team from Keio University in Japan, working with a researcher at Imperial College London, have discovered that the shape of the epidermal cells combined with their ability to temporarily glue together, may explain how they form this strong barrier.

Wei Long Ng explained: «The two - step bioprinting strategy involves the fabrication of hierarchical porous collagen - based structures (that closely resembles the skin's dermal region), and deposition of epidermal cells such as keratinocytes and melanocytes at pre-defined positions on top of the biomimetic dermal skin constructs, to create 3D in - vitro pigmented human skin constructs.

The researchers suggest that a shape of an epidermal cell is actually a flattened version of a tetrakaidecahedron — a 14 - sided 3D solid made out of six rectangular and eight hexagonal sides.

Not exact matches

Interestingly, they found that stem cells coming from different epidermal compartments present very similar response during wound repair, despite the fact that they are recruited from different regions of the epidermis.

The key to the buttercup's glow seems to lie in the exceptionally flat cells of its epidermal layer.

This keeps a portion of the incoming light from reaching the starch layer, ensuring that it is reflected in a directional manner by the flat cells at the base of the epidermal layer.

«CRKII most likely regulates the stability of mutated epidermal growth factor receptors and drives cancer growth by promoting signaling, or communication, within cancer cells,» said Julia Petschnigg, lead author on the paper and a postdoctoral fellow at U of T. «We found that a combinatorial chemotherapy that inhibits those mutated receptors and CRKII could be beneficial in treating lung cancer.»

Importantly, the new technique grows the pluripotent stem cells as floating spheres in high concentrations of two growth factors, fibroblast growth factor - 2 and epidermal growth factor.

«We also need to establish the role of the host epidermal cells that the dermal papilla cells interact with, to make the new structures.»

A comparison of epidermal equivalents generated from iPSC, hESC and primary human keratinocytes (skin cells) from skin biopsies showed no significant difference in their structural or functional properties compared with the outermost layer of normal human skin.

Human epidermal equivalents representing different types of skin could also be grown, depending on the source of the stem cells used, and could thus be tailored to study a range of skin conditions and sensitivities in different populations.»

Among patients with advanced non-small cell lung cancer without a mutation of a certain gene (EGFR), conventional chemotherapy, compared with treatment using epidermal growth factor receptor tyrosine kinase inhibitors, was associated with improvement in survival without progression of the cancer, but not with overall survival, according to a study in the April 9 issue of JAMA.

Epidermal growth factor receptor (EGFR) mutations found in the circulating free tumor DNA (ctDNA) from the plasma of advanced non-small cell lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient - matched tumor tissue DNA.

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

«It turns out that the same signal — the so - called epidermal growth factor (EGF) pathway — control both the formation of pipes and beta cells through polarity changes.

De Luca's team used a patch of skin a little bigger than a U.S. postage stamp from an unblistered part of the boy's groin to culture epidermal cells, which include stem cells that periodically regenerate the skin.

The study, called «Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients.

Concurrently, this dermal cell aggregation triggers the mechanosensitive activation of β - catenin in adjacent epidermal cells, initiating the follicle gene expression program.

Epidermal growth factor receptor (EGFR) signal transduction plays a major role in growth, proliferation and differentiation of mammalian cells.

But Raz and colleagues have found that TPRV1 is also expressed by epithelial cells of the intestines, where it is activated by epidermal growth factor receptor or EGFR.

Josef Singer and Judith Fazekas, both lead authors of the study, discovered that a receptor frequently found on human tumor cells (epidermal growth factor receptor or EGFR) is nearly 100 percent identical with the EGF receptor in dogs.

One of the key metabolic alterations that takes place during EMT is that of the epidermal growth factor receptor (EGFR) which is a pathway that regulates growth, survival, proliferation, and differentiation in mammalian cells.

The researchers, including scientists from pharmaceutical company AstraZeneca, report in an advanced online publication in Nature Medicine on May 4, that their findings indicate «an underappreciated genomic heterogeneity» in mechanisms of resistance to tyrosine kinase inhibitor (TKI) drugs that target the Epidermal Growth Factor Receptor (EGFR) mutation that drive some cases of non-small cell lung cancer (NSCLC).

Scientists have previously known the epidermis consists of a thick outer barrier of dead epidermal cells, which are constantly shedding.

The authors of the study say their new understanding of how epidermal cells form a barrier may explain the paradox of how we can shed them without compromising our skin's integrity.

As soon as we got it out of the package, she became a diligent young investigator, studying the leg of a fly, dog cardiac muscle and onion epidermal cells.

If left untreated, transplanted pluripotent cells only form the epidermal layer of the skin.

In contrast to embryos, lipid - containing structures in enterocytes and in epidermal cells of adult animals are smaller in mutants than in wild type animals.

Changes in cell junctions induced by inhibition of epidermal growth factor receptor in oral squamous cell carcinoma cells.

(E) and (G) W01A8.1 a / c:: GFP expression in epidermal cells and intestinal cells of a young adult hermaphrodite.

Derivation of pluripotent stem cells, either of embryonic origin or following genetic reprogramming, has opened the path for an alternative source for epidermal cell therapy as these cells are both immortal and pluripotent, theoretically capable of providing any requested number of cells of any desired phenotype.

We observe that protein isoforms expressed from W01A8.1 are cytoplasmic proteins, residing predominantly on membranous structures of enterocytes and epidermal cells that have the characteristics of lipid droplets.

Cell division was also stimulated with epidermal growth factor (EGF) at 10 ng / ml in a total added volume of 20 ml.

(A) The onset of expression of W01A8.1 a / c:: GFP in epidermal cells and in intestinal cells of three-fold embryo.

Basic fibroblast growth factor reduces scar by inhibiting the differentiation of epidermal stem cells to myofibroblasts via the Notch1 / Jagged1 pathway.

The translational fusion constructs resulted in high levels of cytoplasmic proteins present in intestinal and epidermal cells on vesicular structures with the characteristic appearance of lipid droplets.

In addition to causing proteins to be secreted through general pathways from the cell and pathways involving metalloproteases, PMA specifically causes activation of an epidermal growth factor receptor (EGFR).

In contrast to embryos, lipid - containing structures in intestinal and epidermal cells of adult W01A8.1 null mutants (Figs. 5J and 5L) were smaller than lipid - containing structures in control animals (Figs. 5I and 5K).

Finally, we demonstrate that treatment of T - 47D cells with epidermal growth factor (EGF), which promotes cell ruffling, stimulates increased accumulation of activated matriptase at the sites of membrane ruffling, suggesting a possible functional role at these sites.

DENVER — Leptomeningeal metastases (LM), a devastating complication and predictor of poor survival in lung cancer patients, was found to be more prevalent in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations.

We are using live cell imaging, single cell analysis and gene editing to resolve the molecular determinants of human epidermal progenitor cell division outcomes (two progenitors, two differentiating cells or one or each) and the mode of cell division (maintenance mode vs repair mode).

Equally impressive is the ability of a caudal fin to regenerate bone, nerves, blood vessels, epidermal, and pigment cells in about 7 - 10 days following complete amputation.

Confocal images were taken at days 1, 2, 3, 4, 5, 6, 8, and 10, on another set of roots allowing the measurement and counting of the cells along single epidermal cell files.

To confirm, evaluate, and quantify the extent of such exponential behavior in individual plant roots, we analyzed root epidermal (trichoblast, to be able to recognize root hair) and cortex cell files of wild ‐ type Col ‐ 0 ecotype, from day 1 to 10 postgermination (Materials and Methods, Dataset EV1).

Along the same lines, in non-small cell lung cancer (NSCLC), acquired resistance to Gefitinib / Erlotinib kinase inhibitors has also been associated with a secondary mutation of the gatekeeper Thr790 residue of the epidermal growth factor receptor (EGFR).

4 Epidermal Stem Cell Lab, Department of Bioscience Technology, Chung Yuan Christian University, Chung - Li, Taiwan

Morphologically, the DZ in the wild type (WT) is marked by the appearance of epidermal root hairs on the external surface of outer cell files (trichoblast) and the existence of fully differentiated xylem for internal cell files (Dolan et al, 1993; Ishikawa & Evans, 1995; Beemster et al, 2003; Verbelen et al, 2006; Zhang et al, 2010; Mähönen et al, 2014).