Sentences with phrase «of epidermal growth factor»

Along the same lines, in non-small cell lung cancer (NSCLC), acquired resistance to Gefitinib / Erlotinib kinase inhibitors has also been associated with a secondary mutation of the gatekeeper Thr790 residue of the epidermal growth factor receptor (EGFR).

His graduate work at Yale University involved making lots of mutations in the transmembrane region of the epidermal growth factor receptor (EGFR) and collecting data on which mutations affected dimerization.

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.

Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy - refractory, advanced colorectal cancer.

Urokinase - type plasminogen activator receptor regulates a novel pathway of fibronectin matrix assembly requiring Src - dependent transactivation of epidermal growth factor receptor.

In addition to causing proteins to be secreted through general pathways from the cell and pathways involving metalloproteases, PMA specifically causes activation of an epidermal growth factor receptor (EGFR).

Multiple mechanisms collectively regulate clathrin - mediated endocytosis of the epidermal growth factor receptor.

RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis.

Changes in cell junctions induced by inhibition of epidermal growth factor receptor in oral squamous cell carcinoma cells.

One of the key metabolic alterations that takes place during EMT is that of the epidermal growth factor receptor (EGFR) which is a pathway that regulates growth, survival, proliferation, and differentiation in mammalian cells.

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

About 15 to 20 % of breast cancers are classified as «triple negative,» so called because these tumors do not express three key proteins that are biomarkers and / or drug targets for breast cancer: the estrogen receptor, the progesterone receptor, and HER2 (a member of the epidermal growth factor receptor family).

Right after childbirth, the colostrum contains high amounts of epidermal growth factor.

Not exact matches

Increased epidermal growth factor levels in human milk of mothers with extremely premature infants.

Findings of the research, published April 22 in the journal Mucosal Immunology, reveal that a substance found in animal and human breast milk called epidermal growth factor, or EGF, blocks the activation of a protein responsible for unlocking the damaging immune cascade that culminates in NEC, a disease marked by the swift and irreversible death of intestinal tissue that remains one of the most - challenging - to - treat conditions.

High total and saturated fat intake were associated with greater risk of estrogen receptor - and progesterone receptor - positive (ER+PR +) breast cancer (BC), and human epidermal growth factor 2 receptor - negative (HER2 --RRB- disease, according to a new study published April 9 in the Journal of the National Cancer Institute.

Clinically important findings suggest that targeting the epidermal growth factor receptor (EGFR) and the fibroblast growth factor receptor (FGFR) cellular pathways may benefit thousands of patients with this disease, according to the study published today in the journal PLOS Genetics.

Between 10 and 30 percent of NSCLC cases are driven by mutations in the epidermal growth factor receptor (EGFR) gene.

Researchers found that a combination of drugs — one targeting epidermal growth factor receptor (EGFR) and one targeting tumor necrosis factor (TNF)-- effectively blocks the cancer from using TNF as an escape route.

By using a range of tissue stains, they were able to assess levels of oestrogen receptor (ER), progesterone receptor (PR) and HER2 — human epidermal growth factor — in order to divide the samples into four subtypes.

«CRKII most likely regulates the stability of mutated epidermal growth factor receptors and drives cancer growth by promoting signaling, or communication, within cancer cells,» said Julia Petschnigg, lead author on the paper and a postdoctoral fellow at U of T. «We found that a combinatorial chemotherapy that inhibits those mutated receptors and CRKII could be beneficial in treating lung cancer.»

Importantly, the new technique grows the pluripotent stem cells as floating spheres in high concentrations of two growth factors, fibroblast growth factor - 2 and epidermal growth factor.

Among patients with advanced non-small cell lung cancer without a mutation of a certain gene (EGFR), conventional chemotherapy, compared with treatment using epidermal growth factor receptor tyrosine kinase inhibitors, was associated with improvement in survival without progression of the cancer, but not with overall survival, according to a study in the April 9 issue of JAMA.

Epidermal growth factor receptor (EGFR) mutations found in the circulating free tumor DNA (ctDNA) from the plasma of advanced non-small cell lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient - matched tumor tissue DNA.

Human epidermal growth factor receptor 2 (HER2) is upregulated in a subset of human breast cancers.

The analysis also found that Asian / Pacific Islander women were more likely to be diagnosed with another subtype of breast cancer: so - called human epidermal growth factor receptor 2 (HER2)- overexpressing breast cancer.

«It turns out that the same signal — the so - called epidermal growth factor (EGF) pathway — control both the formation of pipes and beta cells through polarity changes.

Researchers at the San Diego Supercomputer Center (SDSC) and the Moores Cancer Center at the University of California, San Diego, have described for the first time the molecular mechanism of cancer development caused by well - known «resistance» mutations in the gene called epidermal growth factor receptor (EGFR).

The study, called «Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients.

The advent of therapies directed at tumors with mutations in epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and B - Raf proto - oncogene (BRAF) genes over the past decade have dramatically changed outcomes, he says.

Epidermal growth factor receptor (EGFR) signal transduction plays a major role in growth, proliferation and differentiation of mammalian cells.

But Raz and colleagues have found that TPRV1 is also expressed by epithelial cells of the intestines, where it is activated by epidermal growth factor receptor or EGFR.

Approximately 10 - 15 % of Caucasian and 30 - 35 % of Asian patients with NSCLC have a mutation in the epidermal growth factor receptor (EGFR), which can be successfully targeted with EGFR inhibitors called tyrosine kinase inhibitors (TKI), such as erlotinib, gefitinib and afatinib.

Josef Singer and Judith Fazekas, both lead authors of the study, discovered that a receptor frequently found on human tumor cells (epidermal growth factor receptor or EGFR) is nearly 100 percent identical with the EGF receptor in dogs.

Alice Shaw recalls a signal moment in 2004 — just as she was finishing her oncology fellowship at MIT — when scientists discovered that mutations in a gene for epidermal growth factor receptor (EGFR) were the culprits in about 10 to 15 percent of lung cancer patients.

The researchers, including scientists from pharmaceutical company AstraZeneca, report in an advanced online publication in Nature Medicine on May 4, that their findings indicate «an underappreciated genomic heterogeneity» in mechanisms of resistance to tyrosine kinase inhibitor (TKI) drugs that target the Epidermal Growth Factor Receptor (EGFR) mutation that drive some cases of non-small cell lung cancer (NSCLC).

However, contrary to other studies of astrocyte de-differentiation [3, 4], epidermal growth factor (EGF)- mediated signaling had no role in astrocyte to NSC conversion.

Epidermal - growth - factor - induced proliferation of astrocytes requires Egr transcription factors.

PALLAS: Palbociclib Collaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib with Standard Adjuvant Endocrine Therapy versus Standard Adjuvant Endocrine Therapy Alone for Hormone Receptor Positive (HR +) / Human Epidermal Growth Factor Receptor 2 (HER2)- Negative Early Breast Cancer

Cell division was also stimulated with epidermal growth factor (EGF) at 10 ng / ml in a total added volume of 20 ml.

An Open Label, Phase II Study of Neratinib in Patients with Solid Tumors with Somatic Human Epidermal Growth Factor Receptor (EGFR, HER2, HER3) Mutations or EGFR Gene Amplification

Basic fibroblast growth factor reduces scar by inhibiting the differentiation of epidermal stem cells to myofibroblasts via the Notch1 / Jagged1 pathway.

Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas.

Zhang, Y. and Wolf - Yadlin, A. and Ross, P. L. and Pappin, D. J. and Rush, J. and Lauffenburger, D. A. and White, F. M. (2005) Time - resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.

Finally, we demonstrate that treatment of T - 47D cells with epidermal growth factor (EGF), which promotes cell ruffling, stimulates increased accumulation of activated matriptase at the sites of membrane ruffling, suggesting a possible functional role at these sites.

Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma.

The first relies on the biochemical properties of a drug, while the second uses the antigen / antibody connection.26 The use of biotynilated - epidermal growth factor (EGFR) has been used to enhance the accumulation of cisplatin.27 Other local factors in the respiratory system influencing the absorption are the local transporters and genes.

Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation.

Differential effects of low - and high - dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion.

Growth factor receptor binding protein 2 - mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocyGrowth factor receptor binding protein 2 - mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocygrowth factor receptor is essential and sufficient to support receptor endocytosis.