Basic fibroblast growth factor reduces scar by inhibiting the differentiation
of epidermal stem cells to myofibroblasts via the Notch1 / Jagged1 pathway.
Not exact matches
Interestingly, they found that
stem cells coming from different
epidermal compartments present very similar response during wound repair, despite the fact that they are recruited from different regions
of the epidermis.
Importantly, the new technique grows the pluripotent
stem cells as floating spheres in high concentrations
of two growth factors, fibroblast growth factor - 2 and
epidermal growth factor.
Human
epidermal equivalents representing different types
of skin could also be grown, depending on the source
of the
stem cells used, and could thus be tailored to study a range
of skin conditions and sensitivities in different populations.»
De Luca's team used a patch
of skin a little bigger than a U.S. postage stamp from an unblistered part
of the boy's groin to culture
epidermal cells, which include
stem cells that periodically regenerate the skin.
Derivation
of pluripotent
stem cells, either
of embryonic origin or following genetic reprogramming, has opened the path for an alternative source for
epidermal cell therapy as these
cells are both immortal and pluripotent, theoretically capable
of providing any requested number
of cells of any desired phenotype.
4
Epidermal Stem Cell Lab, Department
of Bioscience Technology, Chung Yuan Christian University, Chung - Li, Taiwan
The research, described in the journal
Stem Cells under the title «Reprogramming Postnatal Human
Epidermal Keratinocytes Toward Functional Neural Crest Fates,» was supported by grants from the National Institutes
of Health.
Epidermal stem cells from mouse tail skin visualized by wholemount 3D immunostaining: Left panel shows epidermal stem cells marked with BrDU (Label Retaining Cells); Middle and right panels Show expression of keratin - 15 and high expression of integrin alpha6, resp
Epidermal stem cells from mouse tail skin visualized by wholemount 3D immunostaining: Left panel shows epidermal stem cells marked with BrDU (Label Retaining Cells); Middle and right panels Show expression of keratin - 15 and high expression of integrin alpha6, respecti
cells from mouse tail skin visualized by wholemount 3D immunostaining: Left panel shows
epidermal stem cells marked with BrDU (Label Retaining Cells); Middle and right panels Show expression of keratin - 15 and high expression of integrin alpha6, resp
epidermal stem cells marked with BrDU (Label Retaining Cells); Middle and right panels Show expression of keratin - 15 and high expression of integrin alpha6, respecti
cells marked with BrDU (Label Retaining
Cells); Middle and right panels Show expression of keratin - 15 and high expression of integrin alpha6, respecti
Cells); Middle and right panels Show expression
of keratin - 15 and high expression
of integrin alpha6, respectively.
By turning on a single gene, researchers can prevent skin
stem cells from maturing into the three types
of adult skin
cells —
epidermal, sebaceous and hair
cells.
Effects
of telomerase and telomere length on
epidermal stem cell behavior.
Title: Transplantation and Tracking
of Autologous
Epidermal Neural Crest
Stem Cells into the Spinal Cord
of Dogs with Acute Severe Spinal Cord Injury