Krassioukov and his colleagues are currently collaborating with colleagues in the U.S. on a larger trial, examining the benefits
of epidural stimulation on a bigger group.
To that end, UofL is screening participants for a six - year study that will further explore the life - enhancing effects
of epidural stimulation on people with spinal cord injury (SCI).
Now three years later, the key findings documented in Brain detail the impact
of epidural stimulation in four participants, including new tests conducted on Summers.
However, in the presence
of epidural stimulation, all four recovered voluntary control of their lower extremities, surprising researchers who believed at least some of the sensory pathway must be intact for epidural stimulation to be successful.
When coupling the intervention with rehabilitative therapy, the impact
of epidural stimulation intensified.
«Because
of epidural stimulation, they can now voluntarily move their hips, ankles and toes.
Research in animals with spinal injuries has shown that this type
of epidural stimulation can activate neural circuits in the spinal cord and enable them to use sensory information from the legs to coordinate the muscle contractions necessary for standing and taking a step, Edgerton said at the press conference.
Not exact matches
A recent study comparing women's choices
of pain relief in midwife - led and consultant - led units in Ireland showed that when women were offered other options such as hydrotherapy and transcutaneous electrical nerve
stimulation, fewer women chose
epidural analgesia [9].
Edgerton is also working with various collaborators on NIBIB - funded projects to explore whether
epidural stimulation can be used to help patients with paralysis
of the upper limbs.
The initial research hypothesis stated that the two participants with the American Spinal Injury Association Impairment Scale (AIS) classification
of AIS A would not elicit any voluntary movement, despite the therapy intervention, and the two participants who were AIS B would develop voluntary movement following a combination
of training and
epidural stimulation.
These results were achieved through continual direct
epidural electrical
stimulation of the participants» lower spinal cords, mimicking signals the brain normally transmits to initiate movement.
However, the implications
of this study for the entire field are quite profound and we now can envision a day where
epidural stimulation might be part
of a cocktail
of therapies used to treat paralysis.»
Four young men who have been paralyzed for years achieved groundbreaking progress — moving their legs — as a result
of epidural electrical
stimulation of the spinal cord, an international team
of life scientists at the University
of Louisville, UCLA and the Pavlov Institute
of Physiology reported today in the medical journal Brain.
«
Epidural stimulation shown to normalize blood pressure following spinal cord injury: Research supports future study
of beneficial effects
of stimulation.»
This work builds on previous research at KSCIRC showing benefits
of spinal cord
epidural stimulation, along with activity - based training, in which individuals with SCI have achieved voluntary movement, standing and stepping, and improved bladder, bowel and sexual function.
Darrel made the decision to have electrodes surgically implanted over his spinal cord in 2016 to test out a treatment known as
epidural stimulation in the hopes
of improving some
of the side effects.
In addition, Kessler is partnering with the University
of Louisville to investigate
epidural stimulation, in which a chip is implanted to deliver an electrical current through the spine to trigger walking.
Other avenues
of exploration for Kessler include Hocoma's LokomatPro V6 and
epidural stimulation.
«
Epidural stimulation electrodes are implanted during surgery and are located right on the surface
of the spinal cord, so they require little current to activate the spinal cord,» Moritz explained.