Sentences with phrase «of epigenetic data»

The TMWG kit incorporates Cambridge Epigenetix's TrueMethyl oxidative bisulfite (oxBS) technology, which allows researchers to accurately quantify different DNA modifications at single - base resolution, as well as proprietary library preparation methods designed to overcome the limitations of traditional bisulfite library construction, and to improve the yield and quality of epigenetic data.

ChroGPS is a software application that serves to facilitate the analysis and understanding of epigenetic data and to extract intelligible information, which can be downloaded free of charge in Bioconductor (www.bioconductor.org), a reference repository for biocomputational software.

Not exact matches

A recent flurry of conferences have forwarded the idea of creating an international epigenome project that could centralize the data, set goals for different groups, and standardize the technology for decoding epigenetic patterns.

In June, the European Human Epigenome Project released its data on epigenetic patterns of three human chromosomes.

Preliminary data from another study of theirs suggest that Fresno youth, by moving elsewhere to attend college, might see a reversal of some epigenetic changes to their immune cells.

Epigenetic data spanning a much longer interval in human prehistory could reveal that the process was key to adapting quickly to a wide range of environmental conditions during the Pleistocene.

The data from the study demonstrate that KZFP partner up with transposable elements to create what the authors call «a largely species - restricted layer of epigenetic regulation.»

They review data relating to birth size and early growth in both preterm and term born infants and emerging data on the role of epigenetic mechanisms.

For his study of cancer and epigenetics, «ENCODE data were fundamental,» says Mathieu Lupien, a molecular biologist from the University of Toronto in Canada who was not associated with ENCODE.

What's more, the researchers hope to be able to add other types of «omics data such as RNA sequencing, epigenetic information, and histone modifications.

Because the epigenetic study looked at the broader genome of NK cell DNA, not just at the IL - 10 gene, Tarrio added, the researchers can now go back to the data to look for other proliferation - induced changes.

Gilean McVean, who studies statistical genetics at the University of Oxford University in the United Kingdom, says much stronger data are needed to make the case that nutritional signals are transmitted through epigenetics.

But the new data showing that a large fraction of epigenetic signatures of ethnicity reflect something other than ancestry suggests that abandoning the idea of race and ethnicity altogether could sacrifice a lot of valuable information about the drivers of differences in health and disease between different communities.

Professor Widschwendter says: «The data is encouraging since it shows the potential of a blood based epigenetic test to identify breast cancer risk in women without known predisposing genetic mutations.»

Analysis of genomic, epigenetic, and RNA sequencing data revealed that the combinations of mutations that lowered the levels of functioning BRCA1 and BRCA2 RNA — genes that produce the breast cancer tumor suppressor proteins — were associated with significantly better survival outcomes.

-- In silico basic and systems biology: We develop innovative approaches to reverse engineer biological networks from omics data, model tumor progression at the genomic, transcriptomic and epigenetic level, automatically annotate new proteins and functional elements through integration of complex and heterogeneous data, including data obtained from high - throughput sequencing or time - lapse video - microscopy.

Using data from blood and brain tissue, a team led by researchers at Johns Hopkins Bloomberg School of Public Health found that they could gain insights into mechanisms that might help explain autism by analyzing the interplay between genes and chemical tags that control whether genes are used to make a protein, called epigenetic marks.

Epidapo (Epigenetics, Data, Politics), a joint unit of the the French CNRS (Centre National de la Recherche Scientifique) and UCLA, located within the latter, and housing social and life scientists, proposes to study the UDN from a sociological point of view.

«Cross-tissue integration of genetic and epigenetic data offers insight into autism spectrum disorder» was written by Shan V. Andrews, Shannon E. Ellis, Kelly M. Bakulski, Brooke Sheppard, Lisa A. Croen, Irva Hertz - Picciotto, Craig J. Newschaffer, Andrew P. Feinberg, Dan E. Arking, Christine Ladd - Acosta, M. Daniele Fallin

While evidence obtained in our and other laboratories strongly suggests that H. pylori triggers a transcriptional response, epigenetic alterations and DNA damage in infected cells, most of the data supporting these findings rest on fragmentary analyses of clinical samples and cells infected in vitro.

Current explorations into the molecular underpinnings of cell circuitry are leveraging multiple data types including expression profiling and epigenetic analysis leveraging RNA - seq and CHiP - Seq coupled with molecular markers and cellular phenotypes.

With the sequence data in hand, the scientists were able to categorize the genes into three groups, each modified by different combinations of the two epigenetic markers.

The investigation, led by Åsa Johansson (Uppsala University / SciLifeLab), combined data on e.g. DNA methylation levels, an epigenetic feature, with measurements of protein biomarkers for cancer, inflammation and cardiovascular disease.

The investigation, led by Åsa Johansson (Uppsala University / SciLifeLab), combined data on e.g. DNA methylation levels, an epigenetic feature, with measurements of protein -LSB-...]

The quality and novelty of the data, leads to new insights into the replication landscape of the human genome and to further unravel the links between replication, gene expression, epigenetic modification and 3D genome organization in normal and cancer cells.

Yann Hérault's team at the IGBMC (Strasbourg, France) and the Institut Clinique de la Souris (PHENOMIN - ICS) have recently published data helping to better understand neurocognitive pathways affected in the pathology; this work in the framework s of the European consortium GENCODYS («Genetic and Epigenetic Networks in Cognitive Dysfunction») has been done in collaboration with the teams of Hendrik Stunnenberg and Hans van Bokhoven from the Raboud University (Nijmegen, Netherlands), and the IGMM (Montpellier, France).

These data define a critical role for MORC2 in epigenetic silencing by the HUSH complex and provide a mechanistic basis underpinning the role of MORC2 mutations in CMT disease.

City of Hope is home to diabetes experts from all over the world, who are studying genetic and epigenetic signatures in patients, using data from the most well - known, longest - ranging diabetes clinical trial.

«The data show that aberrant epigenetic gene programming can now be considered a hallmark of acute lymphoblastic leukemia, occurring in all patients regardless of the presence of genetic mutations,» Melnick said.