Sentences with phrase «of epigenetic enzymes»

My research centralized around the role of epigenetic enzymes — KDM5s and EZH2 in multiple cancers.

Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion.

Not exact matches

«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.

Already, Surani's and Hanna's groups have used the artificial PGCs to investigate the role of individual enzymes in epigenetic regulation, which may one day show how the epigenetic networks are involved in disease.

Before now, a lot of this epigenetic research had been done in yeast — single cell organisms that also use enzymes to lay chemical tags on histone proteins.

While various molecular biology techniques were initially used to identify and validate epigenetics enzymes and their substrates, novel approaches are now available to perform pharmacological characterization of histone - modifying enzymes.

The team has been able to prove that such epigenetic alterations are associated with the increased levels of an enzyme, namely DNA methyltransferase 3A (DNMT3A), which is responsible for the acquisition of the suppressive properties of these cells that develop in the tumoral microenvironment.

This study represents a step forward in understanding the underlying mechanisms of T - cell function and epigenetic regulation of the HDAC11 enzyme.

Tet2 is a type of cellular enzyme known as an epigenetic regulator — responsible for making specific chemical annotations to regions of DNA that alter the activity of many different genes.

The discovery of small molecule regulators (activators or inhibitors) of epigenetic modification enzymes provides researchers with pharmacological tools with which to investigate the biological consequences of chromatin modifications.

We are exploring the roles for epigenetic enzymes, small non-coding RNAs, and DICER 1 in the initiation and maintenance of abnormal DNA methylation patterns in cancer.