Sentences with phrase «of epigenetic gene regulation»

The Sarma laboratory is interested in the mechanisms of epigenetic gene regulation, or how the dynamic modifications of the architecture of chromatin, the complex of DNA and proteins within the nucleus of our cells, impacts gene expression and cellular function.

His fundamental work has provided novel insights into the mechanisms of epigenetic gene regulation.

Not exact matches

The evidence for epigenetic effects on emotion regulation is quite solid: Early caregiving experiences can affect the expression of the genes that regulate a baby's stress and they can shape how the endocrine system will mobilize to stress.

For 50 years, the fundamental principles and mechanisms of the epigenetic regulation of gene expression have been explored across myriad organisms and human diseases.

Epigenetic mechanisms give tortoiseshell cats their markings, but are also involved in our development in the womb and the day - to - day regulation of our genes

There already has been great effort to elucidate the mechanisms of gene expression regulation, but it will be important to continue research to fully realize the potential of these epigenetic therapies and their applications in clinical settings.

Rather the opposite was true, the altered epigenetic regulation of the gene was responsible for the development of the fatty liver,» added Sophie Saussenthaler, who shared the first authorship with Baumeier.

Beverly A. Purnell Senior Editor Education: B.S., Shepherd College; M.S., Ph.D., The Pennsylvania State University Areas of responsibility: Developmental biology, gene regulation, stem cells, reproductive biology, molecular biology, epigenetics E-Mail: [email protected]

The chemical modification of histones is thought to be a form of epigenetic information — information separate from our DNA — that controls gene regulation.

The researchers linked the excess weight and changes in metabolism to epigenetic modifications that reduce expression of the gene for adiponectin — a hormone that helps regulate several metabolic processes, including glucose regulation.

Epigenetic changes do not alter the structure of the DNA, but they do change the way the DNA is modified, which subsequently determines the potential of gene regulation.

Instead, viruses mute the immune system by epigenetic regulation — instead of changing the actual code of genes, viruses change the degree to which genes are expressed.

Methyl labels in the DNA play a key role in this «epigenetic» regulation of gene activity.

Hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes, including those for cell cycle regulation, receptors, DNA repair, and apoptosis (5, 6, 7, 8).

Chromatin structure contributes to the epigenetic regulation of gene expression, DNA replication or DNA repair.

Epigenetics involves the regulation of genomic functions, including gene expression.

Studies could include examining the activation and deactivation of genes (e.g., transcription factors or epigenetic regulation) or involve more classical genetic identification studies.

Protein complexes, epigenetic regulation of gene expression and cancer.

The isoforms of this histone play complex regulatory roles in several cellular processes — epigenetic regulation of gene expression, selective regulation of developmental genes, and telomere maintenance — that could contributed to tumor growth and progression if dysregulated.

Researchers have identified a host of factors involved in epigenetic control of gene expression and development, but many of the precise mechanisms underlying this type of regulation remain unclear.

Through this packaging mechanism, researchers think that histone proteins are the key to regulating access to the genetic information by making different parts of the DNA accessible to factors that express the gene, so - called epigenetic regulation.

Research Focus: I dedicate my time and effort to develop high - throughput sequencing technologies such as single cell transcriptomic, ChIP - Seq, ChIA - PET, and many more... The scientific rational is to understand better and with a different angle, the mechanisms of epigenetic regulation of gene expression in (rare) immune cells, pathologically relevant in many diseases such as asthma, SLE, tuberculosis...

We found that genes within islands of differentiation were enriched for several functional classes (Table S4), and most terms were related to transcription and epigenetic pathways (e.g. chromatin organization and modification, regulation of transcription and translation, DNA binding).

Her scientific expertise lies in understanding the epigenetic basis of gene regulation during embryonic development and disease ontology.

The gene content of these regions, which in several cases reached gene - level resolution, suggests an important role for epigenetic and transcription regulation in the maintenance of reproductive barriers.

This observation and the availability of a reference rabbit genome allowed us to identify several candidate genes for reproductive isolation in this system that suggest an important role for epigenetic and transcription regulation in the maintenance of reproductive barriers.

Xu is developing computational algorithms for the design and analysis of high - throughput biological experiments with a focus on applications in transcriptional and epigenetic gene regulation.

Although the mechanism of age - related decline in DNA repair capacity is unknown, growing evidence suggests that epigenetic events (e.g., DNA methylation) contribute to the ageing process and may be functionally important through the regulation of the expression of DNA repair genes.

The afternoon of the second day focused on somatic changes in melanoma, that is changes that occur in the tumour itself, and this session saw talks from ESR07 Sofia Chen on the mutational landscape of primary melanoma tumours; ESR08 Catarina Salgado on DNA hydroxymethylation (a form of regulation) in melanoma and naevi; and ESR10 Adriana Sanna on epigenetic regulation (reversible changes to the DNA which can turn genes on / off) of melanoma cell phenotypes.

Professor Dockrell and her group are investigating mechanisms that regulate the production of immune - related proteins, starting from gene regulation (epigenetics), gene expression (transcriptomics), cell phenotypes (flow cytometry) and finally protein release.

We have found that blastocysts produced by suboptimal IVC exhibit transcriptional repression of some genes (Sox2, Hdac1, Kap1, Dnmt1, and Dnmt3a) that are modifiers of epigenetic gene silencing through the regulation of the transcription of specific genes, which involves changes in the chromatin state.

Throughout the 2000s, Wistar scientists made seminal discoveries in the field of epigenetics and RNA transcription, contributing new knowledge on the role of histone modifications in gene regulation and DNA repair and how different RNA species, including microRNAs (miRNA) and long noncoding RNAs (lncRNA), are generated and how they regulate gene transcription.

How does regulation of gene expression determine inner ear function on a genetic and epigenetic level?

Dynamic epigenetic regulations of the Gdnf gene play significant roles in identifying both the susceptibility and the adaptation responses to chronic stressful events.

We want to understand this observation through the investigation of gene regulation in the context of the epigenetic landscape.