Lead researcher Dr Gabriella Ficz from QMUL's Barts Cancer Institute said: «It's surprising that cells from several healthy individuals are so permissive to gaining this epigenetic change and that one «hit» from an epigenetic editing tool is sufficient to set off this chain
reaction of epigenetic inheritance and establish a cancer cell - like gene expression signature.»
The improved sensitivity of μChIP - seq, developed jointly by Klugland, Ren and John Arne Dahl of Oslo University, led to «some remarkable discoveries that have completely changed our
view of epigenetic inheritance mechanisms,» says Ren.
Molaro, A. and Hodges, E. and Fang, F. and Song, Q. and McCombie, W. R. and Hannon, G. J. and Smith, A. D. (2011) Sperm Methylation Profiles Reveal
Features of Epigenetic Inheritance and Evolution in Primates.
The
idea of epigenetic inheritance of sexual phenotypes solves the puzzle of why parthenogenetically - produced daughters carrying only maternal chromosomes exclusively develop into queens and why parental phenotypes (nymph - or worker - derived reproductives) strongly influence caste differentiation of offspring.