Sentences with phrase «of epigenetic modifiers»

In addition to effects on translation and DNA replication gene expression, high - replicate RNA - seq in morphologically normal individuals demonstrates a stable regulatory response of epigenetic modifiers and the specific de-repression of a group of zinc finger genes residing in constitutive heterochromatin.

These services are aimed to deliver high quality sequencing - ready libraries to map chromatin states (histone modifications), or profile binding of epigenetic modifiers (transcription co-regulators) or DNA binding proteins (transcription factors) on a genomic scale.

First observed in B - cell lymphoma, recurrent mutations of epigenetic modifier genes have recently been identified in PTCL - NOS. 9 In the present study, we performed targeted sequencing of the main epigenetic modifier genes in a large cohort of Chinese PTCL - NOS patients.

A total of 91 somatic mutations of epigenetic modifier genes were identified in 60 of 125 (48.0 %) patients with PTCL - NOS by targeted sequencing (Figure 1A).

Not exact matches

The researchers also showed just how flexible their LITE system could be by applying it to altering gene expression via epigenetics with the addition of histone modifiers.

Below you'll find some of the CRISPR - based epigenetic modifiers avaliable from Addgene.

Both of these methods also recruit epigenetic machinery - but is there an advantage to using direct epigenetic modifiers?

In contrast, many scientists consider that chromatin does not form an independent epigenetic layer of the genome and that chromatin modifiers do not operate independently of a DNA sequence specific targeting mechanism, such as transcription factors.

Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise

Interestingly, it has been reported that reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Kap1, cause an increased phenotypic noise, suggesting that faithful epigenetic control of transcription is central to suppressing deleterious levels of phenotypic variation [43].

Suboptimal IVC reduced the expression of Kap1, Sox2, Hdac1, Dnmt1, and Dnmt3a, suggesting a molecular epigenetic role for gene expression modifiers in the origin and transmission of these abnormal phenotypes.

We have found that blastocysts produced by suboptimal IVC exhibit transcriptional repression of some genes (Sox2, Hdac1, Kap1, Dnmt1, and Dnmt3a) that are modifiers of epigenetic gene silencing through the regulation of the transcription of specific genes, which involves changes in the chromatin state.

Finally, we analyzed, through gene silencing, the effect of IVC on the mRNA expression at the blastocyst stage for 11 known gene expression modifiers of epigenetic reprogramming.

In this work, we have analyzed at blastocyst stage the expression of some genes that are modifiers of epigenetic gene silencing that produce considerable variance in many complex traits in inbred individuals reared in controlled environments [39, 40].