Sentences with phrase «of epigenetic regulators»

E. Korb et al. «Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Bd4 Inhibition,» Cell 170 (September 7, 2017): 1209 - 1223.

We apply advanced reverse genetic strategies, some of which were developed by us, to analyze select classes of epigenetic regulators in both organisms.

«Through this assessment of epigenetic regulators, we identified PRMT1 as a top scoring «hit» in these patient - derived tumors,» said Virginia Giuliani, Ph.D., senior research scientist, IACS.

One of these, a novel inhibitor of the epigenetic regulator KDM4, co-developed in the lab of Prof. Schüle, showed promising results.

Now, they have discovered that an inhibitor of the epigenetic regulator KDM4 shows great promise in modulating breast cancer stem cell pathology.

Not exact matches

Durect, Corp., a biopharmaceutical company developing therapeutics based on its epigenetic regulator program and proprietary drug delivery platforms, posted an all - time low of 61 cents in November 2012 before embarking on an uptrend that topped out at $ 3.42 in June 2015.

The field of cancer epigenetics was recently transformed by the finding that genes encoding for epigenetic regulators are among the most commonly mutated genes in human cancers.

Scientists from the cluster of excellence BIOSS Centre for Biological Signalling Studies at the University of Freiburg and the Freiburg University Medical Center have shown that inhibiting the epigenetic regulator KDM4 might offer a potential novel treatment option for breast cancer patients.

His team's previous work had hinted that FMRP controls a group of proteins called epigenetic regulators.

«Multiple epigenetic regulators participate in the drug - desensitizing pathway, so they could serve as new targets to improve therapy for this type of cancer.»

Identified additional novel epigenetic and transcriptional regulators of cardiac hypertrophy and heart failure pathogenesis

Discovered that BET bromodomain epigenetic regulators function as critical drivers of heart failure pathogenesis and vascular injury responses that can be pharmacologically targeted in vivo

The fact that she has found them to be differentially regulated in angiosarcoma tumors has led to the hypothesis that there are epigenetic regulators of these genes that have yet to be identified through the genomic profiling applied to these studies thus far.

This activation is achieved by proteins called epigenetic regulators, which work to make specific regions of our genome more or less accessible to transcription.

I graduated with my thesis on «Epigenetic regulators in normal and malignant development of skin» while working with Prof.Dr.Karin Scharffetter - Kochanek.

Tet2 is a type of cellular enzyme known as an epigenetic regulator — responsible for making specific chemical annotations to regions of DNA that alter the activity of many different genes.

She explains, «We think that HDAC2 serves as a master regulator of memory gene expression, and during Alzheimer's disease it's elevated so it causes an epigenetic blockade if the expression of those memory genes.»

Many other molecules are also involved in this process, including epigenetic regulators that help to densely pack the genome into the nucleus of a cell, or locally unpack it to allow gene expression.

The researchers say they've found evidence that obesity changes the microRNA (miRNA) signature — epigenetic regulators of gene expression — in both the dad's sperm and the daughter's breast tissue, suggesting that miRNAs may carry the epigenetic information from obese dads to their daughters.

Michelle Barton, Ph.D., was nominated and elected by her scientific peers in recognition for her contributions to understanding the function of the tumor suppressor, p53 in stem cells, particularly with respect to the discovery of TRIM24, an E3 - ligase and epigenetic regulator that is overexpressed in many cancers.

The discovery of small molecule regulators (activators or inhibitors) of epigenetic modification enzymes provides researchers with pharmacological tools with which to investigate the biological consequences of chromatin modifications.

Interestingly, the most commonly mutated set of genes were those involved in epigenetic modification (25 % of tumors) followed by transcriptional regulators and MAP kinase - associated genes (12 - 15 %).

We applied our technology to several epigenetic regulators, recovering bi-allelic targeted clones with a high efficiency of 60 % and used Flp recombinase to restore expression in two null cell lines to demonstrate how our system confirms causality through mutant phenotype reversion.

Next up was Didier Trono who talked about how transposable elements and their epigenetic control mechanisms are key regulators of transcriptional networks in PSCs.