Partial epilepsy accounts for approximately 60 %
of all epileptic patients, with Mesial Temporal Lobe Epilepsy being the most common form.
Electrodes implanted deep in the brains
of epileptic patients have detected single neurons dedicated to the recognition of a particular person in different situations and guises.
But it wasn't until May this year that researchers measured the firing of mirror neurons in humans directly, using electrodes implanted in the brains
of epileptic patients awaiting surgery (Current Biology, vol 20, p 750).
Since then more than 100
of his epileptic patients with electrodes implanted in their brains for diagnostic purposes have volunteered as subjects for basic research.
Simultaneously there arose in my mind the image
of an epileptic patient whom I had seen in the asylum, a black - haired youth with greenish skin, entirely idiotic, who used to sit all day on one of the benches, or rather shelves against the wall, with his knees drawn up against his chin, and the coarse gray undershirt, which was his only garment, drawn over them inclosing his entire figure.
Not exact matches
I do not debate with people who think we should treat epilepsy by casting demons out
of the
epileptic person; I do not waste time engaging those medical opinions that suggest that bleeding the
patient might release the infection.
Team leader Olaf Blanke, a medical doctor who has treated
epileptic and stroke
patients who have had out -
of - body experiences, placed a camera six and a half feet behind the back
of each
of 14 participants wearing 3 - D video goggles.
Patients with epilepsy often have ECoG arrays temporarily implanted in their brains to determine the location in the brain of epileptic seizures, so the scientists were able to study all the data collected from five such patients on healthy, seizure - free
Patients with epilepsy often have ECoG arrays temporarily implanted in their brains to determine the location in the brain
of epileptic seizures, so the scientists were able to study all the data collected from five such
patients on healthy, seizure - free
patients on healthy, seizure - free nights.
«New analysis
of brain network activity offers unique insight into
epileptic seizures: Researchers are exploring «evolving
epileptic brain networks» to gain a better understanding
of brain activity in epilepsy
patients and the roles played by different regions
of the brain.»
Because lack
of sleep can provoke seizures, these
patients stay awake all night to speed the onset
of an
epileptic episode and shorten their hospital stay.
Fried led an international team in studying 12 UCLA
epileptic patients who had electrodes implanted in their brains in order to pinpoint the origin
of their seizures prior to surgery.
Then a frustrated group
of epilepsy physicians invited computer nerds around the world to take a shot instead, providing data sets recorded from the brains
of human epilepsy
patients and
epileptic dogs.
This second option inspired neurologist Josef Parvizi, psychologist Kalanit Grill - Spector and their colleagues at Stanford University to conduct a study
of 10
epileptic patients.
Nicholas Steinmetz and colleagues found that some mice expressing the genetically - encoded calcium sensor GCaMP6 display brief bursts
of electrical activity, commonly observed in
epileptic patients and animal models.
Current non-invasive techniques can't detect
epileptic areas
of the brain smaller than approximately eight to 10 square centimeters, so many early - stage epilepsy
patients often go undiagnosed and untreated.
Loeb and colleagues used a technique called magnetic resonance spectroscopy to identify the metabolomic signature
of epileptic versus non-
epileptic brain tissues removed from nine
patients who underwent invasive electrical brain monitoring as part
of their epilepsy surgery.
Surgery to remove areas
of the brain associated with
epileptic activity can help prevent seizures in these
patients.
Due to the build - up
of toxic glycogen clumps in neurons and other cell types,
patients with this disease commonly experience severe
epileptic seizures, motor impairment, muscle spasms, and dementia.
Professor Patrik Verstreken (VIB - KU Leuven): «Our work shows that increasing specific brain fats at the synapses
of patients with a TBC1D24 mutation is a possible strategy for preventing
epileptic seizures.
More animal studies would be needed to move this drug toward human clinical trials, but «what we hope is that we could use this drug to intervene in
patients who have had an episode
of prolonged seizures and give it to them briefly following that episode to protect them from becoming
epileptic,» said James McNamara, M.D., a professor in the departments
of neurobiology and neurology at Duke University.
Surgery can be an option for a minority
of patients who do not respond to medications or other treatments and have
epileptic scar tissue that can be removed safely.
The research for the study was conducted on 19
epileptic patients at the UCLA Medical Center, who required invasive monitoring
of brain activity prior to potential surgical excision
of seizure - causing areas
of the brain.
In fact, Upton says, if the cycle
of headaches — or seizures, for
epileptics — is broken, then the
patient may «forget» the pattern
of electrical activity that leads to the symptoms.
One third
of patients do not respond to medication and an alternative can be surgery to locate and remove the small cluster
of neurons that act as the seed
of an
epileptic seizure, unfortunately such surgeries often fail to bring any relief.
The ability to reliably pinpoint the anatomical source
of epileptic seizures, different for each
patient, remains elusive.
These unexpected findings may be related to the
epileptic phenotype
of many pedigrees
of patients with early - onset familial AD and to the hyperactivation
of neuronal networks in
patients with sporadic AD and amyloid - positive nondemented subjects.
A recent clinical study that emerged from their research revealed
epileptic activity in roughly 40 %
of Alzheimer
patients tested.
These findings are probably related to the
epileptic phenotype
of many pedigrees
of patients with early - onset familial AD and to the hyperactivation
of neuronal networks in
patients with sporadic AD and amyloid - positive nondemented subjects.
Led by staff scientist Keith Vossel, MD, the team
of researchers used sophisticated technologies to detect «subclinical»
epileptic activity (too subtle to be noticed on standard clinical exams) and showed that Alzheimer
patients with such activity had a faster cognitive decline than those without.
Dr. Milner is best known for work with an
epileptic patient known as H.M., who had become unable to form new memories after having parts
of both temporal lobes
of his brain surgically removed.
We implemented a rare variant transmission disequilibrium test (TDT) to search for autosomal recessive
epileptic encephalopathy genes in a cohort
of 320 outbred
patient - parent trios that were generally prescreened for rare metabolic disorders.
«We might have some real insight into the advantages
of dampening
of synaptic activity that is caused by fasting,» said Haghighi, for example, how fasting can be beneficial for
epileptic patients, who can experience reduced seizures when restricting calories.
Vitamin D can improve seizure control in
epileptics, relieve memory loss and confusion in Alzheimer's
patients, and protect against age - related macular degeneration, the leading cause
of blindness.
The most commonly accepted theory among scientists as to why keto works for
epileptic patients is that on the diet the number
of ketones in the body spike.
In ketosis, the body is fueled by fat (ketone bodies) rather than glucose (carbohydrates)-- this helps
epileptic patients by changing the metabolism
of the brain, and the same changes might be beneficial for migraneurs.
You can use this Indian version
of ketogenic diet plan for any
epileptic patient as well.
We've also referenced service dogs employed by
epileptic patients, potentially warning their owners
of an impending episode and attracting the attention
of others.
But listening to music could help prevent
epileptic seizures, according to US study that found the brains
of patients with reacted differently to certain types
of music than those without the disorder.