Sentences with phrase «of epithelial barrier»

«However, prolonged exposure [to Alternaria] leads to disruption of epithelial barrier function that would ultimately reduce mucociliary clearance,» the researchers wrote.

Efficient repair of the epithelial barrier is critical for suppressing inflammation and reestablishing intestinal homeostasis.

The researchers thus suspect that they play a major role in ensuring the integrity of the epithelial barrier function.

Not exact matches

The research team, led by Georgia State University and the University of Michigan, wanted to understand how a wound heals in the intestine because in IBD, which includes Crohn's disease and ulcerative colitis, damage to the intestinal epithelial barrier allows bacteria in the intestine to go across the barrier and stimulate the body's immune system.

Using a crystal structure of a complex protein compound of botulinum neurotoxin, Rongsheng Jin, associate professor of physiology & biophysics at UC Irvine, and collaborators found that these compounds — called clostridial hemagglutinin (HA)-- bind with epithelial cell proteins in the intestines of patients, which initiates a process that disrupts the close intercellular seals so that the complex toxin molecules can slip through the epithelial barrier.

In addition, the combination of defective epithelial barrier and abnormal epithelial cell extrusion observed in this mouse model may be further exploited to study the role of Alix in cancer.

The epithelial barrier in the choroid plexus of the brain is the blood - cerebrospinal fluid interface.

«This detection activates cell - signaling pathways that produce antimicrobial peptides, suppress the growth of harmful bacteria, and maintain the integrity of the intestine's epithelial barrier.

Corresponding to the primary function of epithelial tissues, i. e. forming a barrier between compartments, epithelial cells form tight adhesions between each other, and display only lateral mobility, confined by the basement membrane.

In each route of infection, spores or vegetative bacteria must translocate through an epithelial barrier in order to disseminate and cause disease.

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

B. anthracis secretes lethal toxin, which contributes to barrier disruption via interference of epithelial, endothelial and immune cell function [5].

Efficient wound healing is required to maintain the integrity of the intestinal epithelial barrier because of its constant exposure to a large variety of environmental stresses.

This lining consists of a layer of epithelial cells that come together to form a barrier that is impenetrable to the nanoparticles, thereby necessitating the use of injections to be an effective form of treatment.

Another issue is that mucus is essential for immunity at epithelial surfaces, and glycosylation is essential for the integrity of cellular junctions and tissue barriers such as the intestinal and blood - brain barriers.

Diversity of tight junctions (TJs) between gastrointestinal epithelial cells and their function in maintaining the mucosal barrier.

The small intestine and the stomach are lined with epithelial cells that are connected together by tight junctions similar to the tight junctions in the blood brain barrier (BBB) of the brain.

In the small intestine, gluten triggers the release of zonulin, a protein that regulates the tight junctions between epithelial cells and therefore intestinal, but also blood - brain barrier function.

But it does exist and has been studied for some time: «The blood - brain barrier (BBB) is formed by epithelial - like high resistance tight junctions within the endothelium of capillaries perfusing the vertebrate brain.»

The lining of the gastrointestinal (GI) tract is composed of small epithelial cells that act as a barrier between the interior and the exterior of the body.

Probiotics strengthen the intestinal epithelial barrier so that the damaging contents of the gut remain out of our bodies.