The cost of testing (and often re-testing because
of false positive test results) could possibly hinder the success of a spay and neuter program.
Not exact matches
The data presented last week, though not peer - reviewed, suggests they can do that remarkably well — with the algorithm, in the five - minute
testing windows, detecting AFib with a 99.3 % rate
of sensitivity and a 0.8 % rate
of «
false positives.»
The national cost
of false -
positive tests and overdiagnosed breast cancer is estimated at $ 4 billion a year, according to a 2015 study in Health Affairs.
They suggest most women in their 40s should not have routine mammograms because the
tests may cause more harm than good because
of false positive results (follow - up
testing proves negative for cancer).
A new genetic
test that analyzes the free DNA floating in a pregnant woman's blood was proven to be more effective at predicting chromosomal disorders compared with standard screening
tests, due to its much smaller incidence
of false -
positive results.
THE BIOPSY»S DANGEROUS CASCADE: HOW TO LESSEN THE NEED FOR INVASIVE
TESTING Intervention Track Hosted By: Insigniam Current medical
tests are too often marred by high rates
of overdiagnosis («
false positive» results) or they too often miss the danger altogether («
false negatives»).
Unless you think the amounts
of the decay element are varying just the right amount to give a
false positive to highly repeatable
tests and calibrations from samples all over the world (and beyond with meteorites), then you are wrong.
Christian disbelief is, instead, a
positive testing of what is true and
false by a single criterion: «By this you know the Spirit
of God: every spirit which confesses that Jesus Christ has come in the flesh is
of God, and every spirit which does not confess Jesus is not
of God» (1 John 4:2 — 3).
This study leaves open the question
of whether the green tea
tested in this study is contaminated with gluten or if something in the green tea is causing
false positive results.
Fearful
of a mass drug -
test failure — poppy seeds are said to cause
false positives — Chimello ordered flight attendants to replace the offending rolls with unseeded ones.
But then again, the thousands
of false positives on a cancer screening also suffer in some ways, the emotional stress, the follow - up
testing, etc..
Although we do not have results
of confirmatory
testing, we would expect a similar rate
of false positives for our screening.
Rather than being «confirmed,» they were «validated» through a series
of simpler follow - up observations and complex statistical
tests designed to rule out
false positives.
Because only about 16 in every 100,000 people end their own lives, a
test with such a level
of accuracy will give many
false positive and
false negative results if used on the general population.
She points out that the
test would have to have a very low rate
of false positives to avoid putting healthy people at risk
of picking up diseases from other, genuinely infected people.
A study published this month, and paid for by Sequenom, found that the company's
test has a
false positive rate
of 0.2 % (G. E. Palomaki et al..
Because ovarian cancer is relatively rare, occurring in approximately one out
of every 2,500 women, a
test with only 99 percent specificity would result in
false -
positive diagnoses for 25 women, leading to unnecessary and risky surgeries and procedures.
If you're
testing a long shot, say with a 10 percent chance
of being effective, the
false positive risk for a P value
of.05 is 76 percent.
But cost - benefit decisions, even as the price
of Tc - 99m rises when supply shrinks, should include the cost
of follow - up
tests after a
false -
positive thallium scan, he urges.
Dr. Catalona, who was the first physician in the U.S. to run the phi
test, added, «However, the problem is that higher levels
of PSA can also be caused by a benign enlargement or inflammation
of the prostate, leading to many
false ‐
positives for cancer and ultimately unnecessarily invasive biopsies and an increased potential for patient harm.»
Results
of a multi ‐ center clinical study found a 31 percent reduction in unnecessary biopsies due to
false ‐
positives as a result
of using the phi
test.1
More work is needed to refine the
tests so that they can detect tinier amounts
of target molecule, and ensure the rates
of false positives and negatives meet the standards required for diagnostic
tests.
«Such a high rate
of a
false positives in this particular study was unexpected,» says Tandy - Connor, who believes that some
of the discrepancies in the results can be explained by technical differences between the various
testing methods used.
As the authors note, the blood
test's» accuracy may be even higher as some
of the «
false positives» — healthy cases mischaracterized as AD — may be from subjects who are actually
positive for pre-symptomatic manifestations
of Alzheimer's.
While there are a number
of portable
tests for cocaine commercially available, these are mainly based on antibody reagents, which can not offer quantitative data and — since the cocaine antibody can bind to something that is not cocaine — can give
false positive results.
In an editorial also published in the July 1 issue
of Annals
of Internal Medicine, Dr. George Sawaya and Dr. Vanessa Jacoby
of the Department
of Obstetrics, Gynecology and Reproductive Sciences at the University
of California, San Francisco write, «The pelvic examination has held a prominent place in women's health for many decades and has come to be more
of a ritual than an evidence - based practice... With the current state
of evidence, clinicians who continue to offer the examination should at least be cognizant about the uncertainty
of its benefits and its potential to cause harm through
false -
positive testing and the cascade
of events it prompts.»
The
test also had a handful
of false positives, however, making its specificity 92 %.
The
test is much less accurate for Edward syndrome and Patau syndrome, however, with respective detection rates
of about 96 % and 92 % and a
false positive rate
of 0.26 %.
The blood
tests, used on at least 2 million people a year, are wrong 50 %
of the time, says WHO, yielding either
false positives or negatives, both
of which are dangerous.
As a result, blood
tests may be detecting the presence
of other mycobacterial infections; they may also produce
false positives when antibody levels remain elevated after cases
of TB have been treated.
Inappropriate
testing for heart attacks increases the cost
of treatment; increases the number
of false positives, which could lead to further
testing and unnecessary consultations; and adds to patient anxiety, said Dr. Anil Makam, Assistant Professor
of Internal Medicine at UT Southwestern and first author
of the study published today in JAMA Internal Medicine.
And skilled staff in good laboratories can almost always distinguish genuine infection from a
false positive by carrying out an array
of tests.
Additionally,
false -
positive results occurred, suggesting contaminations or wrong handling
of the
tests.
The new NIST human genome RMs increase the ability
of DNA sequencing laboratories to be more confident in their reporting
of true
positives,
false positives, true negatives and
false negatives, and therefore, significantly improve genetic
tests used for disease risk prediction, diagnosis, and progression tracking.
«This study has shown that the main advantage
of cfDNA
testing, compared with the combined
test, is the substantial reduction in
false positive rate.
Using a two - tiered
testing strategy, the new
test quickly identified all
of the NPC patients with no
false positives and no
false negatives.
In addition to the huge hit to your wallet, there's also the potential harm
of false positives, and just because a
test has traditionally been done for a condition doesn't mean it's the best way to treat it.
It's highly likely, however, that you have fallen victim to a
false positive — a result that, despite the accuracy
of the
test, erroneously yields an affirmative result that points toward illness.
«Good as gold: Researchers use gold nanoparticles to enhance the accuracy
of biomedical
tests, thereby eliminating
false positive results.»
The assay — when compared against the performance
of the conventional ELISA — has proved to be «up to clinical standards,» according to the researchers, with the added ability
of removing the
false positives, thereby eliminating the need for repeated
testing.
While the result is
false, the psychological toll is real, and so are the billions
of dollars spent every year on
tests and procedures performed as a result
of false positives.
«Our method would be an effective low - cost addition to a battery
of tests helping to lower the
false positive rate since it provides 10 % better sensitivity and specificity than any other screening method, including Pap and HPV
tests,» says Huang.
Results from these
tests provide also in many cases insights into the nature
of the sources
of the
false positives, which are generally produced by one
of several kinds
of configurations involving eclipsing binaries (EB).
Because
of these
false positives, a sequence
of tests - as originally outlined by Alonso et al. (2004)- is employed, beginning with detailed revisions
of the detection light - curves, and continuing for surviving candidates with follow - up observations, to either reject them from the list
of planetary candidates or to verify their planetary nature.
We used a
false discovery rate rather than standard significance measures to avoid an inflated
false -
positive rate as a consequence
of the large number
of hypothesis
tests (42).
We discuss common correction schemes such as Bonferroni, Holm, Benjamini & Hochberg and Storey's q and show how they impact the
false positive rate (FPR),
false discovery rate (FDR) and power
of a batch
of tests.
Identification
of those men at greatest risk for prostate cancer development and progression would provide a means
of targeted screening, thereby reducing unnecessary
testing,
false positive tests, and the burden
of overdiagnosis and over treatment.
A suite
of diagnostic
tests is performed on all candidates to aid in discrimination between genuine transiting planets and instrumental or astrophysical
false positives.
One common cause
of false positives are so - called «high - risk» lesions that appear suspicious on mammograms and have abnormal cells when
tested by needle biopsy.
For models, such as SMR, where the distribution
of the model parameters is unknown, permutation
test and stability selection are typically used to control for
false positives.