«To preserve patient access to this treatment option, and given the scale that we've reached, demonstrating the safety and efficacy
of fecal transplantation through adequate and well - controlled clinical trials is the right thing to do,» explained Carolyn Edelstein, OpenBiome's director of Outreach and Public Affairs, in an op - ed published earlier today with the Fecal Transplant Foundation.
Bacteriotherapy by way
of fecal transplantation can be used to treat recurrent CDAD, which is thought to reestablish the normal colonic microflora.
«Meta studies have shown that the controlled grafting
of fecal transplantation from healthy donors is a safe and very effective treatment of acute diarrheal diseases caused by the pathogenic bacterium Clostridium difficile,» said Sieglinde Angelberger, gastroenterologist at the University Clinic for Internal Medicine III of the Medical University of Vienna and author of the study: «this was the reason why we applied this therapy for the treatment of patients with chronic intestinal diseases.»
Not exact matches
Fecal microbial
transplantation (FMT) has gained acceptance for treating Clostridium difficile infection, a life threatening and difficult to treat dysbiosis that often is caused by heavy use
of antibiotics.
«So far, it has not been sufficiently tested whether and how successful
fecal transplantation is for the permanent settlement
of microbiota from a healthy donor to a patient,» said Alexander Loy
of the Department
of Microbiology and Ecosystem Research, University
of Vienna.
A team led by gastroenterologists Sieglinde Angelberger and Walter Reinisch (Medical University Vienna) and microbiologists David Berry and Alexander Loy (University
of Vienna) explored how a treatment called «
fecal microbiota
transplantation» can be used to support microbial recolonization
of the gut
of patients with chronic intestinal inflammation (ulcerative colitis).
The research also sheds new light on why
fecal microbiota
transplantation may work so well, despite the uniqueness
of each individual's microbiome.
The procedure
of transferring stool to a patient — technically called
fecal microbiota
transplantation — was first performed in the United States in 1958 to treat an intractable case
of C. difficile colitis, a gastrointestinal condition caused when the balance
of microbes in the gut — called the microbiome — is destabilized or destroyed.
«This is the first randomised trial to show that
fecal transplantation may be
of benefit to patients with hepatic encephalopathy.
The authors call for more uniform documentation
of the clinical efficacy and safety
of fecal microbiota
transplantation.
Fecal microbiota
transplantation in the management
of hepatic encephalopathy.
Interestingly, this «leakiness» could be abrogated if the mice were exposed to
fecal transplantation of normal gut microbes.
Analysis
of Treatment Outcomes for Recurrent Clostridium difficile Infections and
Fecal Microbiota
Transplantation in a Pediatric Hospital
Effect
of Vegan
Fecal Microbiota
Transplantation on Carnitine and Choline ‐ Derived Trimethylamine ‐ N ‐ Oxide Production and Vascular Inflammation in Patients With Metabolic Syndrome — Loek P. Smits — Journal
of the American Heart Association
Fecal microbiota
transplantation and its potential therapeutic uses in gastrointestinal disorders — Ryan D. Heath — Northern clinics
of Istanbul
Fecal microbiota
transplantation in puppies with canine parvovirus infection — Giorgio Q. Pereira — Journal
of Veterinary Internal Medicine
OpenBiome was founded to expand safe access to
fecal transplantation for patients with recurrent C. difficile infection and to catalyze research on the role
of the microbiome in human health.
For patients who fail multiple courses
of antibiotic treatment,
fecal transplantation has been shown to prevent recurrence in more than 85 %
of cases.
Finally, we will focus on the results
of different therapeutic approaches in this context: administration
of pre - and probiotics, antibiotics,
fecal microbiota
transplantation and special diets and dietary supplements.
Fecal Microbiota
Transplantation in Inflammatory Bowel Disease - a Primer for the Internists — Gaurav Syal — The American Journal
of Medicine
Analysis
of Treatment Outcomes for Recurrent Clostridium difficile Infections and
Fecal Microbiota
Transplantation in a Pediatric Hospital — Aileen Aldrich — The Pediatric Infectious Disease Journal
Human gut microbiome ** Competitively Selected Donor
Fecal Microbiota
Transplantation: Butyrate Concentration and Diversity as Measures
of Donor Quality.
Fecal Transplantation for the Treatment
of Clostridium difficile Infection.
Editorial Comment:
Fecal microbiota
transplantation as a possible treatment
of irritable bowel syndrome.
Neuroprotective effects
of fecal microbiota
transplantation on MPTP - induced Parkinson's disease mice: gut microbiota, glial reaction and TLR4 / TNF - α signaling pathway.
As the Director
of Policy and Global Partnerships at OpenBiome, Carolyn Edelstein oversees OpenBiome's efforts to expand the availability
of Fecal Microbiota Transplantation overseas, present its work to the public, and contribute to the discourse on the regulation of fecal microb
Fecal Microbiota
Transplantation overseas, present its work to the public, and contribute to the discourse on the regulation
of fecal microb
fecal microbiota.
The Intestinal Microbiome Influences the Response
of Cancers to PD - 1 — Based Immunotherapy: Might
Fecal Transplantation Become Part
of Cancer Therapy?
16S rDNA analysis
of the effect
of fecal microbiota
transplantation on pulmonary and intestinal flora — Tianhao Liu — 3 Biotech
For this subgroup
of patients, a promising new treatment called
Fecal Microbiota
Transplantation (FMT) brings hope.
The first study
of the social and ethical issues associated with a provocative approach to treatment for ulcerative colitis has found that the majority
of potential patients are eager for what is now called «
fecal microbiota
transplantation» to become available, although many have concerns about donor selection, screening, and methods
of delivery.
June 2, 2011 Patients with bowel disease eager to test «
fecal» therapy The first study
of the social and ethical issues associated with a provocative approach to treatment for ulcerative colitis has found that the majority
of potential patients are eager for what is now called «
fecal microbiota
transplantation» to become available, although many have concerns about donor selection, screening, and methods
of delivery.
Our
Fecal Microbiota Transplantation (FMT) residential programs include fecal transplants for the treatment of Clostridium Difficile infection (C.Diff) and a comprehensive educational program for many other conditions including obesity, Crohn's disease, ulcerative colitis, anxiety, depression and schizophr
Fecal Microbiota
Transplantation (FMT) residential programs include
fecal transplants for the treatment of Clostridium Difficile infection (C.Diff) and a comprehensive educational program for many other conditions including obesity, Crohn's disease, ulcerative colitis, anxiety, depression and schizophr
fecal transplants for the treatment
of Clostridium Difficile infection (C.Diff) and a comprehensive educational program for many other conditions including obesity, Crohn's disease, ulcerative colitis, anxiety, depression and schizophrenia.
The 5 - day program for
Fecal Microbiota
Transplantation (FMT) includes two colonics, three infusions (transplants)
of a fresh specimen and a chamomile enema.
Dr. Davis is one
of a handful
of physicians in North America with clinical expertise in
fecal microbiota
transplantation (FMT), which he offers via retention enema and capsule.
Their report, «Commentary on key aspects
of fecal microbiota
transplantation in small animal practice» (J. Chaitman, et al, Veterinary Medicine: Research and Reports, May 31, 2016), addressed FMT mechanisms, indications, donor selection, preparation, administration, safety, and regulation.
The purpose
of this study was to determine if
fecal transplantation could be used to cure Clostridium perfringens infections that were not cured by treatment with metronidazole and amoxicillin trihydrate / clavulanate potassium.