Not exact matches
«Large aggregates
of ALS - causing protein might actually help brain cells: UNC School
of Medicine scientists add to evidence that small aggregates
of SOD1 protein are the brain - cell killing culprits in ALS, but the
formation of larger, more visible, and
fibril - like aggregates
of the same protein may protect brain cells.»
Scientists attribute more than 20 human diseases to the
formation of amyloid
fibrils.
University
of Wisconsin - Madison professor Martin Zanni used a sophisticated technique that relies on 2 - D infrared spectroscopy to follow the sequence
of events in the chemical reactions leading to
fibril formation.
We are interested in the role
of secretory chaperones in the biochemistry and cell biology
of the neuron and have shown that two small secretory chaperones can block the
formation of both Abeta oligomers and
fibrils in vitro and neurootoxic aggregates in cell culture models.
The symposium will summarize new aspects
of tooth enamel production, collagen
fibrils formation, the role
of glycosaminoglycans and their interaction with proteins, and the tissue engineering
of cartilage and bone.