Sentences with phrase «of fibrotic»

In areas where there is a selenium deficiency, use of rapeseed oil has been associated with a high incidence of fibrotic lesions of the heart, called Keshan's disease.20 The animal studies carried out over the past twenty years suggest that when rapeseed oil is used in impoverished human diets, without adequately saturated fats from ghee, coconut oil or lard, then the deleterious effects are magnified.

Serrapeptase is an exceptional fibrinolytic enzyme that has the ability to digest and liquefy large amounts of fibrotic scar tissue.

«Our data are a strong proof of principle and the first to show that inhibiting fibronectin polymerization preserves heart function, reduces left ventricle remodeling and limits formation of fibrotic connective tissue,» said lead investigator of the study and director of translational research in the Heart Institute and the Center for Translational Fibrosis Research.

Co-precipitating of fibrotic lesions as demonstrated by collagen expression in acinar cells may be attributed to defence mechanism against inflammatory cytokine - induced pancreatic injury and inflammation [26]; interestingly, the collagen expression was restored when pancreatic inflammation was relieved [46].

Not exact matches

Cirrhosis is a consequence of chronic liver disease characterized by replacement of liver tissue by fibrotic scar tissue as well as regenerative nodules, leading to progressive loss of liver function.

It's time we began to learn about its role in fibrotic scarring of the lens in cataract formation and other diseases.»

The firm dropped discovery and development in the areas of diabetes, virology, and neuroscience in favor of a research focus on oncology, heart failure, genetically defined diseases, immunoscience, and fibrotic diseases.

The problem arises in this case from a faulty fibrotic conversion and enlargement of the heart.

«In the future, these results could also lead to new therapeutic options for the treatment of other fibrotic diseases.»

«There could be potential long - term therapeutic treatments that could arise from this new knowledge, which can be explored for the treatment of additional fibrotic disorders including kidney disease.»

Dr. Summer and colleagues are currently working to develop a therapy that could restore lipid production in the lungs of pulmonary fibrosis patients and slow the fibrotic process.

Now, in a new study published in the journal Cell, scientists at the Salk Institute for Biological Studies have discovered that a synthetic form of vitamin D, calcipotriol (a drug already approved by the FDA for the treatment of psoriasis), deactivates the switch governing the fibrotic response in mouse liver cells, suggesting a potential new therapy for fibrotic diseases in humans.

The Salk discovery that calcipotriol counters the fibrotic response in stellate cells illuminates a potentially safer, more effective strategy capable of neutralizing multiple convergent fibrotic triggers.

Salk researchers found that a drug already approved by the FDA for the treatment of psoriasis deactivates the switch governing the fibrotic response in mouse liver cells, suggesting a potential new therapy for fibrotic diseases in humans.

Fibrotic diseases, such as chronic kidney disease and failure, lung disease, heart failure and cirrhosis of the liver, are estimated to be responsible for up to 45 percent of deaths in the developed world.

Previously Dr. Martini worked at Shire plc in Lexington, Mass., as Senior Director of Discovery Biology and Translational Research, Mass., focusing on fibrotic diseases of muscle, kidney, skin, lung, bone marrow and metabolic liver diseases, with particular emphasis on different therapeutic modalities for pathway modulation.

Research Focus: My research projects are focused on the roles of TNF family members linked to fibrotic disorders associated with scleroderma, atopic dermatitis, idiopathic pulmonary fibrosis and asthma.

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.

These observations do illustrate for the characteristic of AP and chronic pancreatitis like changes exemplified with fibrotic lesions [26].

Myofibroblasts can proliferate elsewhere in the body as well — although they may arise from different cell types in different tissues — and fibrotic remodeling of the kidney, liver (cirrhosis of the liver) and lungs follows a similar progression, Genin says.

In this way, they can mimic the fibrotic changes characteristic of a heart attack and those characteristic of hypertension.

These fibrotic processes, nowadays more frequently detected, may be related to defects in the repair process and / or to an increased incidence of autoimmune diseases due to ageing.

Molecular mechanisms leading to pDC dysregulation and persistent type I IFN signature are largely unexplored, especially in systemic sclerosis (SSc), a disease in which pDCs infiltrate fibrotic skin lesions and produce higher levels of IFNα as compared to healthy controls.

In specific aim II, the role of miR - 24 and its target proteins in inflammatory and fibrotic processes in CNV are being assessed.

High levels of heart disease are associated with selenium - deficient soil in Finland and a tendency to fibrotic heart lesions is associated with selenium deficiency in parts of China.

One study of Chinese children consuming rapeseed oil indicated an association with Keshan's disease, which causes fibrotic lesions on the heart (2).

Unfortunately, about two - thirds of the mono - unsaturated fatty acids in rapeseed oil are erucic acid, a 22 - carbon monounsaturated fatty acid that had been associated with Keshan's disease, characterized by fibrotic lesions of the heart.

It also helps increase production of glutathione, the liver's main antioxidant and «detoxifier» and protects against fibrotic changes in the liver.

Muscle inflammation due to many autoimmune diseases (Masticatory myositis, Eosinophilic Myositis, Polymyositis, Myositis Ossificans, Fibrotic myopathy, etc.) can be the cause of high CK blood levels — particularly early in the disease or during flareups.