Not exact matches
Cirrhosis is a consequence
of chronic liver
disease characterized by replacement
of liver tissue by
fibrotic scar tissue as well as regenerative nodules, leading to progressive loss
of liver function.
It's time we began to learn about its role in
fibrotic scarring
of the lens in cataract formation and other
diseases.»
The firm dropped discovery and development in the areas
of diabetes, virology, and neuroscience in favor
of a research focus on oncology, heart failure, genetically defined
diseases, immunoscience, and
fibrotic diseases.
«In the future, these results could also lead to new therapeutic options for the treatment
of other
fibrotic diseases.»
«There could be potential long - term therapeutic treatments that could arise from this new knowledge, which can be explored for the treatment
of additional
fibrotic disorders including kidney
disease.»
Now, in a new study published in the journal Cell, scientists at the Salk Institute for Biological Studies have discovered that a synthetic form
of vitamin D, calcipotriol (a drug already approved by the FDA for the treatment
of psoriasis), deactivates the switch governing the
fibrotic response in mouse liver cells, suggesting a potential new therapy for
fibrotic diseases in humans.
Salk researchers found that a drug already approved by the FDA for the treatment
of psoriasis deactivates the switch governing the
fibrotic response in mouse liver cells, suggesting a potential new therapy for
fibrotic diseases in humans.
Fibrotic diseases, such as chronic kidney
disease and failure, lung
disease, heart failure and cirrhosis
of the liver, are estimated to be responsible for up to 45 percent
of deaths in the developed world.
Previously Dr. Martini worked at Shire plc in Lexington, Mass., as Senior Director
of Discovery Biology and Translational Research, Mass., focusing on
fibrotic diseases of muscle, kidney, skin, lung, bone marrow and metabolic liver
diseases, with particular emphasis on different therapeutic modalities for pathway modulation.
In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models
of age - related
disease, exploiting the high dependence
of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation
of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models
of diseases of aging like osteoarthritis, 12
fibrotic lung
disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related
diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.
These
fibrotic processes, nowadays more frequently detected, may be related to defects in the repair process and / or to an increased incidence
of autoimmune
diseases due to ageing.
Molecular mechanisms leading to pDC dysregulation and persistent type I IFN signature are largely unexplored, especially in systemic sclerosis (SSc), a
disease in which pDCs infiltrate
fibrotic skin lesions and produce higher levels
of IFNα as compared to healthy controls.
High levels
of heart
disease are associated with selenium - deficient soil in Finland and a tendency to
fibrotic heart lesions is associated with selenium deficiency in parts
of China.
One study
of Chinese children consuming rapeseed oil indicated an association with Keshan's
disease, which causes
fibrotic lesions on the heart (2).
Unfortunately, about two - thirds
of the mono - unsaturated fatty acids in rapeseed oil are erucic acid, a 22 - carbon monounsaturated fatty acid that had been associated with Keshan's
disease, characterized by
fibrotic lesions
of the heart.
In areas where there is a selenium deficiency, use
of rapeseed oil has been associated with a high incidence
of fibrotic lesions
of the heart, called Keshan's
disease.20 The animal studies carried out over the past twenty years suggest that when rapeseed oil is used in impoverished human diets, without adequately saturated fats from ghee, coconut oil or lard, then the deleterious effects are magnified.
Muscle inflammation due to many autoimmune
diseases (Masticatory myositis, Eosinophilic Myositis, Polymyositis, Myositis Ossificans,
Fibrotic myopathy, etc.) can be the cause
of high CK blood levels — particularly early in the
disease or during flareups.