Feldmann and his colleagues are reporting their results at the 7th International Symposium
of Filoviruses in Washington, D.C., this week.
Comprehensive panel of real - time TaqMan polymerase chain reaction assays for detection and absolute quantification
of filoviruses, arenaviruses, and New World hantaviruses
«The work on antibodies isolated from survivors
of filovirus infections, including Marburg and Ebola, was started by James Crowe's laboratory at Vanderbilt University together with our laboratory about 3 years ago,» said virologist Alex Bukreyev, professor at UTMB and co-corresponding author.
Not exact matches
The study, published by EcoHealth Alliance's Dr. Kevin Olival and Dr. David Hayman from Massey University, reviewed all
of the current literature on
filoviruses — the class
of viruses that include both Ebola and Marburg virus — and took a critical look at the ecological and virological methods needed to understand these viruses to protect human health.
One
of these chemical structures, benzoquinoline, showed antiviral activity against Ebola virus and was also active against another deadly
filovirus, Marburg virus.
Diagnostic reverse - transcription polymerase chain reaction kit for
filoviruses based on the strain collections
of all European biosafety level 4 laboratories
«A nice thing about the
filovirus field is that it was populated by very straightforward, salt -
of - the - earth people,» she says.
But equally intriguing was how few different families
of RNA viruses turned up: just Bornaviruses and
Filoviruses.
Of these, only half have ever been tested for
filovirus, says Peterson.
The researchers engineered a DNAzyme with two loops: one to detect to detect the Marburg sequence, and another to detect a sequence common to all
filoviruses, which includes Marburg and all strains
of Ebola.
Fedson says that many scientists who study
filoviruses like Ebola have yet to catch on to the idea
of treating the immune response.
The WHO
filovirus clinical working group, convened in response to the current outbreak, discussed the evidence on convalescents» serum at a meeting in Geneva, Switzerland, at the end
of July, says Bausch, who is part
of the group.
Because three kinds
of bats from the region are believed to harbor the deadly
filovirus.
In a study reported online this week in BMC Evolutionary Biology, the researchers conclude that
filoviruses have existed for tens
of millions
of years.
Some reports based on the estimated mutation rate
of this virus family have suggested that
filoviruses are a mere 10,000 years old, but Derek Taylor, an evolutionary biologist at the State University
of New York (SUNY), Buffalo, has found a new way to gauge their age.
For the published broad agency announcement, see the April 29, 2016 solicitation, Advanced Development
of Multivalent Vaccine Candidates for
Filovirus and Lassa Fever.
Finding comparable safety and immunogenicity in U.S. and Ugandan populations provided proof
of principle that a protective, multivalent
filovirus vaccine is attainable.
Her work included the genome sequencing
of the Ebola and Marburg
filoviruses and Lassa Fever, as well as joint work to develop possible therapies.
The team is also working on prevention
of related Ebolavirus members Sudan virus (SUDV) and Bundibugyo virus (BDBV), and the related
filovirus Marburg virus.
Developed and optimized protocols for detection
of hemorrhagic fever viruses including
Filoviruses, Arenaviruses and Bunyaviruses (Ebola, Marburg, Lassa, Machupo, CCHF, Rift Valley Fever and others).