Sentences with phrase «of fragments of protein»

The Bristol group has now revealed how the administration of fragments of the proteins that are normally the target for attack leads to correction of the autoimmune response.

Not exact matches

Peptides themselves are actually fragments of proteins, and proteins are the building blocks of your skin.

THE ELUSIVE LIQUID BIOPSY Intervention Track Ballroom C1 Every protein fragment, every strand of microRNA, every sentence and mis - sentence of DNA, every immune system marker, every signature of disease in the human being.

To minimize the allergenic properties of the protein, it is divided into small fragments so that the infant can tolerate them better.

To reduce the allergenic properties of the protein, it is divided into small fragments so that the infant can tolerate them better.

Food allergens (the food fragments responsible for an allergic reaction) are proteins within the food that usually are not broken down by the heat of cooking or by stomach acids or enzymes that digest food.

Levels of a protein fragment in the blood paralleled how long head injuries benched hockey players.

And blood levels of SNTF were much higher one hour to six days later than were levels of the protein fragment in eight other athletes who had gotten concussions that cleared up within five days.

In Robinson's lab, Sharon studied protein - protein interactions within proteasomes, large multiprotein complexes that clear cells of unwanted proteins by degrading them into small peptide fragments.

Hannes Stockinger, the senior author of the study, adds: «If we coupled this delivery method with screening of patient's tumours for the presence of a unique surface protein, which we can target with the Fab fragment - functionalized liposomes, we might be able to treat tumours more efficiently and decrease the side effects of the delivered anti-cancer drugs substantially.

In another study, Rezende helped functionally characterize the specific fragments of the cell surface protein, Als5p, that allows the pathogenic fungus, Candida albicans, to bind to its host.

Each venomous snake species produces a unique venom, a mixture of around 50 - 200 toxic proteins and protein fragments that co-evolve with the typical prey of the snake, such as the smaller reptiles eaten by the eastern coral snake or the rodents preferred by rattlesnakes.

The brains of mice engineered to develop Alzheimer's disease were riddled with these plaques, clumps of amyloid - beta protein fragments, by the time the animals were 10 months old.

She plugged in new x-ray snapshots of p53 fragments and beefed up her program to make a movie of the quivering activity of each of the protein's 1.6 million atoms over a full microsecond, an eternity on the atomic scale that required about a month of supercomputer time.

No. 5,817,479, entitled Human Kinase Homologs, claims 44 ESTs which are fragments of genes encoding protein kinases.

They found that fragments released by the break down of the lung's key proteins (collagen and elastin), are increased in the sputum of patients with TB.

An analysis of the peptide's structure in semen indicated that it hooked up with similar fragments to create amyloid fibers (clusters of protein fragments that have also been implicated in diseases such as Alzheimer's).

The task of HLAs is to bind to fragments of proteins that are broken down in the cells, transport the fragments to the cell surface and present them to the T - lymphocytes.

To get a closer look at the interaction between the antibody and a fragment of the virus» envelope protein, scientists in Pamela J. Bjorkman's lab at Caltech determined the molecular structure formed as the two units interacted.

The presence of the dead, snarled nerve cells and sticky protein fragments characteristic of Alzheimer's in the main smell - processing structures of these deceased patients could suggest the disease gets its start in the olfactory system.

They first injected a fragment of myelin protein into the brains of the test mice, causing nerve damage similar to that seen in MS patients.

But additional research has confirmed that structures resembling blood cells and collagen protein fibers — key elements of connective tissue — were preserved in six of eight fragments.

Most experimental treatments for Alzheimer's have aimed at curbing beta - amyloid, an apparently toxic protein fragment that is the dominant component of amyloid plaques.

Huntington's disease is caused by an expansion of glutamine residues in the huntingtin protein, altering its function and ultimately resulting in toxic aggregation of huntingtin fragments in neurons.

The world's oldest protein fragments of fossilised soft tissue to date were discovered by American scientists, and dated back 80 million years.

Neurobiologist Ulo Langel of Stockholm University in Sweden, with colleagues at several other labs, solved this problem by pairing PNAs with fragments from two other proteins — transportan or pAntp — that use an unidentified mechanism to slip easily into cells.

We now know that plaques are clusters of protein fragments called beta - amyloid peptides.

Polish scientists say they've discovered the world's oldest preserved fossils of blood vessels and fragments of fossilised animal proteins.

To treat humans, researchers must still find a way to deliver the protein fragments past the blood - brain barrier, which prevents circulating proteins from entering the brain, and to the site of the plaques.

The target fragment binds to a gene switch in the DNA, which triggers the production of a colourful substance such as the protein that gives jellyfish a green glow under ultraviolet light, or proteins from bacteria that produce colour changes visible to the naked eye.

When prompted, fragments of a tRNA synthetase come together and charge a tRNA with a bio-orthogonal amino acid (N3), which is inserted as a recognizable tag into all subsequent proteins made in the cell.

The team found that proteins disrupt the crystallization of calcium carbonate, so that what seems at low resolution to be neatly aligned crystals is actually a more fragmented jumble.

The majority of people in this field today believe that the plaques, made of a protein fragment called beta - amyloid peptide (BAP), come first, and that the accumulation of this material causes the rest of the disease.

They found that at 19 and 51 days old, the boy had fragments of the virus's protein coat in his blood.

But when they tested the boy again at 12 months, all traces of both the protein and the gene fragments had gone, and the child had no antibodies to HIV.

Fragmented and separated, the bits of protein are then placed in mass spectrometers.

A protein fragment called amyloid - beta (Aβ) is known to aggregate and create plaque in the brains of Alzheimer's patients.

Later, they reported faint signatures of preserved protein fragments, but no independent group has managed to replicate those findings.

The method has allowed researchers to study key players involved in cell division — which include proteins that form much of the structure of chromosomes, and fragments of DNA that help to orchestrate the process.

The treatment uses tiny droplets of fat, called nanoliposomes, which are coated in protein fragments that are able to stop amyloid protein accumulating into plaques, even at low concentrations.

They reached this conclusion during studies of mice engineered to build up protein fragments in their brains known to cause the disease.

The team identified eight protein fragments, two of which were identical to those found previously.

It binds to wall - building protein fragments called peptides, in particular those that end with two copies of the amino acid D - alanine (D - ala).

But rather than delivering the entire gene for the clotting - factor proteins to cells, as most gene therapies do, the researchers used the viruses to engineer immune - regulating B cells to express a fragment of the clotting factor fused to an immune molecule called an immunoglobulin.

«Telomerase is a unique protein - RNA complex where the protein subunit uses its RNA component as a template to add identical fragments of DNA to the end of chromosomes,» said Emmanuel Skordalakes, Ph.D., associate professor in the Gene Expression and Regulation program of Wistar's NCI - designated Cancer Center.

«Our research work shows that single and artificially composed fragments of the Chikungunya virus surface protein may suffice to induce a partially protective immune response.

Specifically, the release of a stress - coping hormone called corticotropin - releasing factor (CRF), which is widely found in the brain and acts as a neurotransmitter / neuromodulator, is dysregulated in AD and is associated with impaired cognition and with detrimental changes in tau protein and increased production of amyloid - beta — protein fragments that clump together and trigger the neurodegeneration characteristic of AD.

Vaccines made of protein or sugar fragments, also known as subunit vaccines, have been successful against a few diseases, such as hepatitis and diphtheria.

«In the early days, these fragments of RNA were generally dismissed as irrelevant since they did not code for proteins.»

In the new study, a team led by Wiktorowicz ground up a small portion of each of the pottery fragments (or sherds), used detergent and other chemicals to dislodge any proteins stuck to them, and isolated and analyzed the protein fragments using various techniques.