Homodimerization and internalization
of galanin type 1 receptor in living CHO cells.
Recent studies have found elevated levels of this protein in post-mortem brain samples of patients with MS.. In this latest work, investigators compared the frequencies of «more active» and «less active» variants of the DNA sequences that control expression
of the galanin gene between healthy controls and MS patients.
«We hope that our findings will foster development of a personalized strategy for the prevention and treatment of multiple sclerosis, one that takes into account the gender - specific contribution
of galanin gene variants to susceptibility and disease progression,» said Dr. Victoria Lioudyno, lead author of the study.
Not exact matches
The researchers attached these entry keys to PNAs designed to shut down expression
of a test gene — the
galanin receptor gene, which binds a protein,
galanin, that helps regulate everything from pain perception to food intake.
Obesity and endocrine dysfunction in mice with deletions
of both neuopeptide Y and
galanin.
Gutzler, S.J., Karom, M. Erwin, W.D., and Albers, H.E. Seasonal regulation
of social communication by photoperiod and testosterone: effects
of arginine - vasopressi, serotonin, and
galanin in the medial preoptic area - anterior hypothalamus.
Conclusions: Here, we demonstrate that oral
galanin administration improves glucose homeostasis via the enteric nervous system and could be considered a therapeutic potential for the treatment
of T2D.
Oral chronic gavage with
galanin in diabetic mice increases insulin sensitivity, which is associated with an improvement
of several metabolic parameters such as glucose tolerance, fasting blood glucose, and insulin.
Artists: Nicholas
Galanin, Edgar Heap
of Birds, Marcus Amerman, and artist collective Postcommodity (Raven Chacon, Cristóbal Martínez, Kade L. Twist and Nathan Young)
In advance
of his March 28 artist talk at the University
of Minnesota and his participation in the March 29 Walker panel discussion, we share
Galanin's Walker Reader commission on this oft - perpetuated and false dichotomy.