Sentences with phrase «of gametocytes»

Study protocol for a randomised controlled double - blinded trial of the dose - dependent efficacy and safety of primaquine for clearance of gametocytes in children with uncomplicated falciparum malaria in Uganda

About 3 years ago, I performed an experiment that worked out well: Somehow, with careful cultivation, I turned a couple of gametocytes into this thing that knows how to negotiate for ice cream.

Not exact matches

For mosquito transmission to occur, the sexual form gametocytes, which are structurally distinct and have a very different program of gene and protein expression, have to form continually in the blood on a 2 - day cycle.

In what was originally a separate line of investigation, David Baker and Taane Clark and colleagues at the London School of Hygiene & Tropical Medicine and the Wellcome Trust Sanger Institute analyzed the whole - genome sequences of two P. falciparum laboratory strains that they knew were unable to produce gametocytes.

Two teams have independently discovered that a single regulatory protein acts as the master genetic switch that triggers the development of male and female sexual forms (termed gametocytes) of the malaria parasite, solving a long - standing mystery in parasite biology with important implications for human health.

Compared to the new assays, the current molecular standard assay failed to identify 16 % of infections, and at least 40 % of those contained parasite gametocytes, the parasite stage that is transmitted when mosquitoes bite an infected person.

«Finding new drugs that will also target the gametocyte stages of the malaria parasite are essential to reduce its transmission,» Cassera said.

Her newest project, funded by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, will look at the crucial time when malaria is transmitted — when reproductive cell precursors known as gametocytes develop.