Sentences with phrase «of gene copies»

The nuclear pores thus create an environment conducive to the efficient production of gene copies.

Not exact matches

Gene therapy involves the delivery, using a modified virus, of a healthy copy of a gene to make up for one that's deficient in a way that causes diseGene therapy involves the delivery, using a modified virus, of a healthy copy of a gene to make up for one that's deficient in a way that causes disegene to make up for one that's deficient in a way that causes disease.

Also found in the water bear genome were more copies of an anti-oxidant enzyme and a DNA repair gene than in any other animal.

The mechanism then turns off both copies of the browning gene.

To coax the apples to create these particular anti-browning RNA molecules, the scientists gave the apple extra copies of the browning gene that were tweaked to set off the plant's interference mechanism.

Rather than jamming the operon, the relevant genes were copied and placed within the reach of a genetic switch which turned them on.

For Dawkins, by far the most important aspect of biological nature is the ability of certain stretches of DNA («genes») to engender faithful copies of themselves, under conditions that prevail.

My relatively muted response to the refined starches makes me interested in learning how many copies of the AMY1 «carb breakdown» gene I have.

Things get more complicated if the gene is recessive and a woman would need to get copies of the gene from both parents in order to express it.

Since all people have two copies of every gene, combinations of the TAS2R8 gene variants determine whether someone tastes bitter foods intensely.

But those genes don't make you an exact copy of your mom or dad.

If you're a carrier of a defective gene for a recessive disorder, that means you have one normal copy of the gene from one of your parents and one defective copy from the other.

If you have one non-functional copy of the gene, you're fine.

In order for your child to inherit your recessive genetic disorder, such as cystic fibroisis, sickle cell disease, fragile X syndrome or Tay - Sachs, both the male and the female partner have to pass on their copy of the mutated gene.

During reproduction, humans inherit two working copies of most genes — one copy, or allele, from each parent.

The researchers corrected a mutation in liver cells in mice by snipping out the gene and sewing in a healthy copy of it.

Researchers still have much to learn about the imprinting process and the genes involved, Zhang says, but the discovery of a second mechanism for silencing one copy of these genes underscores imprinting's importance.

For a very small number of genes, though, people inherit only one working copy; the other copy is turned off, forever silenced.

Both mouse and human males typically die early from the mutation in Mecp2, because their Y chromosome does not supply a normal copy of the gene.

Lacking money to outfit the new lab, Wang and Xin bought used equipment: a single channel DNA sequencer (bought and barely touched by a Harvard Medical School researcher); second - hand centrifuges and pipettes; a reconditioned CytoScan HD system that detects variations in the number of copies of a gene.

Chen and his colleagues, postdocs Xiongyi Huang, Jennifer Kan, and graduate student Ruijie Zhang, did this by giving the bacteria a copy of a gene that encodes an enzyme called cytochrome P450.

Because there's only one functioning allele of an imprinted gene, if that copy becomes defective, developmental abnormalities can occur.

The scientists are also experimenting with gene therapy, using a harmless virus to deliver a normal copy of the normal CIB2 gene to baby mice that have the mutated version.

These highly repeated bits of DNA are capable of expressing and inserting new copies of themselves back into the genome — hence the sobriquet «jumping genes.»

But a faulty variant of this gene arose six generations ago in an Amish group, causing the people who carry one copy of the variant to produce half as much of the age - promoting protein.

Of these, 43 people carried at least one copy of the gene varianOf these, 43 people carried at least one copy of the gene varianof the gene variant.

Fortunately, humans have a nearly identical copy gene called SMN2, however, SMN2 normally only makes a small amount of the correct SMN protein.

A girl who inherits one defective copy of such a gene from her parents has a backup on her other X chromosome.

This particular founder was born missing the letters A (for adenine) and G (guanine) from the DNA chain at the 185 site on one copy of his or her BRCA1 gene.

A previous study found that today's dogs have many copies of the AMY2B gene, which produces an enzyme that helps break down starch, while wolves have only two copies.

The two parents are healthy because each carries a copy of the gene that works, but their child inherits two damaged copies.

They made these clones by a process called automatic parthenogenesis: The egg is formed normally (with half the species» usual number of chromosomes), then fertilized by the «polar body,» a cell that is created during oogenesis and contains the same gene copies as the egg, resulting in the shark having half the genetic variation of its mother.

About one in 8,000 children is born with some form of SMA in which mutations in both copies of the gene that code for the survival motor neuron (SMN) protein cripples its production.

Embryos die unless they inherit a copy of the antidote gene in either egg or sperm, and so the poison - antidote duo can spread unusually fast through populations.

To account for the remarkable similarity between retrovirus oncogenes and their normal cellular kin, most virologists have settled on the idea that retrovirus oncogenes are copies of cellular genes.

However, in some spots, an organism may have long strips of identical DNA in both copies of a gene.

The mutation is on the X chromosome so female children with two X chromosomes should have at least one functioning copy of the gene.

Taking advantage of the handful of complete human genome sequences now available, the pair looked at how alleles — the two copies of each gene we inherit from our parents — differ within a genome.

The researchers looked at a type of genetic change called copy number variants, which refers to the number of copies of genes in human DNA.

This must be how the first genes, made of RNA, would have copied themselves.

But first he needed copies of the gene; it had to be cloned.

The less adept mice, Rubin's team found, carry extra copies of a previously known human gene called DYRK; a mutated version of an almost identical gene in fruit flies, called minibrain, causes neurological defects.

AN EXTRA copy of a gene on chromosome 21 may explain why people with Down's syndrome are less likely to get breast and lung cancer than the rest of the population.

Tumours in these mice grew 50 per cent more slowly than those in healthy mice, indicating that one extra copy of the gene has a significant effect on tumour growth (Nature, DOI: 10.1038 / nature08062).

Thirty to 50 percent of multiple myeloma patients have extra copies of the gene that encodes the enzyme ADAR1.

Huntington's is heritable — a copy of the gene from either parent guarantees a person will develop the disease.

Instead, ezetimibe blocks dietary cholesterol absorption in the gut by inhibiting the NPC1L1 protein, perhaps approximating the effect of having only one working copy of the NPC1L1 gene.

But beyond simply lowering cholesterol, the 82 people with inactive copies also had about half the risk of coronary heart disease as people with two functional copies of the gene.

For gene therapies, scientists remove most of the AAV genome, replace it with therapeutic genetic cargo, and inject trillions of copies into the patient.

This approach entails transferring a healthy (non-mutant) copy of the defective gene to restore the expression of the missing protein.