Sentences with phrase «of gene data»

Not exact matches

Recently a team of its researchers combed through this data, searching the the genomes of 89,283 people for correlations between particular genes and a person's self - reported status as a lark or night owl.

Spark Therapeutics» stock soared 20 % in Wednesday trading on the heels of its second quarter 2017 earnings report and some (very) early data on the gene therapy - focused firm's treatment for the blood disorder hemophilia A.

KGI's analysis joins Gene Munster of Loup Ventures who collected data on various iPhone 8 configurations and ship times on Apple's website as a snapshot of how the unusual launch is going.

Katherine High, Spark's president and chief scientific officer, expressed her enthusiasm for the early clinical data related to SPK - 8011: «The encouraging start of our SPK - 8011 clinical trial reinforces the strength of our gene therapy platform, delivers human proof - of - concept in a second liver - mediated disease — a significant achievement in the gene therapy field — and positions us well to potentially transform the current treatment approach for this life - altering disease with a one - time intervention.»

Taking the hot seat was vice president of partnerships, Gene Alston, who pre-empted any questioning on the Cambridge Analytica data breach by launching into a pre-prepared pacification at the intro stage of the keynote session.

@Chuckles «DNA works because it works and it is a conduit for different species to spread their genes through» = > definition of faith in the absence of data right there.

Data access and analysis tools are being made available for the 3K RGP dataset through the International Rice Informatics Consortium (IRIC), which promotes collaboration in bioinformatics analysis of rice data and provides computational tools to facilitate rice improvement via discovery of new gene - trait associations and accelerated breedData access and analysis tools are being made available for the 3K RGP dataset through the International Rice Informatics Consortium (IRIC), which promotes collaboration in bioinformatics analysis of rice data and provides computational tools to facilitate rice improvement via discovery of new gene - trait associations and accelerated breeddata and provides computational tools to facilitate rice improvement via discovery of new gene - trait associations and accelerated breeding.

Billions of data points on genes, proteins and other molecules are compiled in large files and systematically studied.

By using this tool to analyze their data the scientists were able to catalogue active alleles in a comprehensive set of mouse tissues, or the mouse «Allelome,» and gain an insight into how this differential gene activity is regulated.

McCallion's strategy to make sense of all this data looks at the active genes in cells affected by a disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for disease risk down to just a handful within any one implicated region.

The large MESA population also provided Rodriguez with a rich data pool: She decided to analyze all known mutations of the SCARB1 gene.

The data suggest that around 3500 B.C. — roughly the same time that many linguists place the origin of PIE and that archaeologists date horse domestication — Yamnaya genes replaced about 75 percent of the existing human gene pool in Europe.

«Our new data is scientifically important because ataluren restores activity to genes inactivated by nonsense mutations, and as a result, it has the potential to do so much for a large number of very complex genetic disorders,» Jacobson said.

profile of NF B - regulated genes and to extract clinically relevant data that could potentially bear on optimal cancer prevention and treatment.

«Together, our data strongly suggest that cutaneous gene therapy with inducible expression of GLP1 can be used for the treatment and prevention of diet - induced obesity and pathologies,» the authors wrote.

An apparently new Variant of human serum albumin, albumin Naskapi, has been found in high frequency in the Naskapi Indians of Quebec and, in lower frequency, in other North American Indians.The family and population data of the albumin are consistent with its inheritance as a simple autosomal trait Controlled by a gene designated Al Naskapi.

Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models.

Extracting clinically relevant information pertinent to a complex disease process, drawing from a data set of 19,000 genes, required a creative rather than systematic research approach.

Brains of individuals who died with Huntington's, Parkinson's or no neurological condition were analyzed using sequencing technology that provides a data readout of the activity of all genes in the genome.

The challenge is substantial — the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus repository (GEO) alone contains 80,985 public datasets, spanning hundreds of tissue types in thousands of organisms — and the rapid growth in data makes it difficult for journals or data repositories to «police» whether datasets that should be made publicly available actually are.

Novel abnormalities in the FGFR gene, called FGFR fusions, were identified in a spectrum of cancers, and preliminary results with cancer cells harboring FGFR fusions suggested that some patients with these cancers may benefit from treatment with FGFR inhibitor drugs, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research.

In a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cooking.

Sarah also interviews Augustine Kong of the Big Data Institute at the University of Oxford in the United Kingdom about his Science paper on the role of noninherited «nurturing genes.»

But as researchers pool data from thousands of cancer gene tests, some of those benign variants may be reclassified as dangerous, or may become informative in ways that hadn't been anticipated.

Inheriting a single X chromosome exposes men to a host of X-linked diseases, such as hemophilia or Duchenne muscular dystrophy, and researchers hope to use the new data to understand more fully the role of genes in other X-linked conditions.

The new analysis, based on data assembled primarily by graduate student Yan - Jie Feng at Sun Yat - Sen University in Guangzhou, China, focused on the sequences of 95 genes located on chromosomes in the nucleus and how they changed over time.

«We used the Allen Human Brain Atlas data to quantify how consistent the patterns of expression for various genes are across human brains, and to determine the importance of the most consistent and reproducible genes for brain function.»

«It is exciting to find a correlation between brain circuitry and gene expression by combining high quality data from these two large - scale projects,» says David Van Essen, Ph.D., professor at Washington University in St. Louis and a leader of the Human Connectome Project.

Rather than supporting a genome duplication event at the time when yeast evolved to have twice the number of chromosomes, their data indicated that the duplicated genes had begun to diverge long before.

Genetic data from ancient Scythian horses indicates that more than 2,000 years of domestication caused changes in horse genes related to mammary gland development and milk production.

Using the new data, Laura Carrel, a geneticist at Pennsylvania State College of Medicine in Hershey, and Huntington Willard, a geneticist at Duke University in Durham, North Carolina, discovered that 15 percent of the genes on the inactivated X chromosome are actually not silenced — and most are likely to be expressed at higher levels overall in women than men.

The largest of its kind, the study examined genetic data in 100,000 individuals including 40,000 people with a diagnosis of schizophrenia and also found that some of the genes identified as increasing risk for schizophrenia have previously been associated with other neurodevelopmental disorders, including intellectual disability and autism spectrum disorders.

The growth of publicly accessible data troves on genome sequences, gene activity, and protein structures and interactions has opened new territory for biologists.

So her team conducted an analysis of the genetic data from 36,626 individuals to see which genes were associated with body fat.

He and his colleagues gathered genetic data from 156 frog species and combined this with earlier information about two genes from 145 different frogs, for a total of 301 distinct frog species from all 55 families of frogs.

The team also examined data from a prior genetic study of children with asthma and found that a variant of the dectin - 1 gene — which reduces production of the receptor — is strongly linked to increased asthma risk.

«For a long time now, the entire field was collecting data on MYC, LIN41, and other genes and proteins without knowing what most of it meant,» said Yamanaka, who is also director of the Center for iPS Cell Research and Application (CiRA) at Kyoto University, and professor at UC San Francisco.

Finally, the authors addressed two major challenges for any study that generates large data - sets of individual genes and proteins in model organisms like yeast: How to assemble the data into coherent maps?

Scientists from the Biogerontology Research Foundation (BGRF), a UK - based charity founded to support aging research and address the challenges of a rapidly aging population, propose a new concept for signalome - wide analysis of changes in intracellular pathways, called OncoFinder, which allows for accurate and robust cross-platform analysis of gene expression data.

«For several years the potential for the use of gene expression data in research and clinical applications has been underappreciated due to the inconsistency of the data coming from the various types of equipment.

They compared each individual's lifespan to that of their relatives and their degree of separation and found that genes explained about 16 percent of the longevity variation seen in their data — on the low end of previous estimates which have ranged from about 15 percent to 30 percent.

«Those modern humans» selected genes under selection may prove central to a relevant process of domestication, given that these interactions may provide significant data on relevant phenotypic traits,» said Boeckx.

«This reemphasizes the need for caution, and it adds some concrete data to help us quantify the risks and benefits,» says Amy Patterson, acting director of the Food and Drug Administration's Division of Cellular and Gene Therapies.

Using genetic data from more than 36,000 people with a variety of autoimmune diseases, researchers found that one genetic variant in the gene that codes for the TYK2 protein...

Co-senior author Professor Jennifer Nichols at the Wellcome Trust - Medical Research Council Stem Cell Institute, said: «Our data allow us to study gene activity in individual cells to an unprecedented level of precision.

In all, the study included the data of more than 23,000 people to show that approximately 12 percent of a person's variation in delay discounting can be attributed to genetics — not a single gene, but numerous genetic variants that also influence several other psychiatric and behavioral traits.

Using computational data analysis, Hughes hopes to create evolutionary trees of these genes and regulatory mechanisms in order to figure out how they work together to make cells function and how they contribute to the physiology of the organisms they are found in.

Using genetic data from more than 36,000 people with a variety of autoimmune diseases, researchers found that one genetic variant in the TYK2 gene protects against a wide range of...

Many genes are likely to influence delay discounting; and some of Dr. Ahokhin's preliminary data suggest that these «impulsivity genes» may include genes coding for enzymes that synthesize the neurotransmitter serotonin and receptors where serotonin binds in the brain.

To figure out what's really happening within an organism — or within a particular organ or cell — researchers are linking the genome with large - scale data about the output of those genes at specific times, in specific places, in response to specific environmental pressures.