Sentences with phrase «of gene dosage»

Here we show that the predominant mechanism determining transcript abundance differences (> 85 %) in Leishmania tropica is that of gene dosage at the level of individual genes or chromosomal somy.

We are also applying CRISPR / Cas9 - mediated genome engineering to develop novel mouse models in order to explore the impact of gene dosage alterations on tumor development in vivo.

In studying the regulation of gene dosage, his lab described the first known biological role of a microRNA in the mammalian system, ultimately revealing a network of microRNAs that titrate the dose of key cardiac gene networks that dictate cell fate and differentiation.

Not exact matches

After determining the proper dosage of tamoxifen — an early trial resulted in a number of mouse deaths due to overactivation of Mecp2 — researchers settled on a four - week regimen of ramping up the gene's function.

Because this imprinting affects hundreds of genes that are non-coding, including microRNAs and non-coding RNAs, it's a very interesting fine - tuning mechanism for the dosage of gene expression in the brain and elsewhere in the body.»

Particularly influential were last year's ruling in Association for Molecular Pathology v. Myriad Genetics Inc. that naturally occurring human genes can not be patented and the 2012 Mayo v. Prometheus decision, which invalidated a patent on a method of adjusting drug dosage using measures of blood metabolites because it relied on a «law of nature.»

Rather gene dosage, which depends on the number of chromosome copies, is responsible for this: «If the chromosome is multiplied, then more copies of the same gene will be transcribed.

Bellott and his colleagues looked closer at the properties of the ancestral Y chromosome genes and found that the majority of them were dosage - dependent — that is, they required two copies of the gene to function.

This leads to degradation of «viral» RNA, preventing its translation on ribosomes into a protein encoded by it, thereby reducing the viral gene expression,» says one of the main co-authors of the research Alexander Timin, a JRF of the Novel Dosage Laboratory at Tomsk RASA Center.

In accordance with the gene dosage, a further reduction of up to 70 % of the wt level was observed in hemizygous XpdTTD / KO cells.

Leukemia in gene therapy trials: a question of vectors, inserts and dosage?»

A hallmark of the Notch pathway is its gene dosage sensitivity, such that small differences in the amount of Notch activity can cause aberrant cell fate choices and T - cell leukemia.

«Gene mutations that cause congenital heart disease lower the levels of these transcription factors by half, and we've shown that the dosage of these factors determines which genes are turned on or off in a cell.

(2) Studying the evolution of gene expression and dosage compensation in Drosophila.

Human cancers exhibit a diverse array of genomic gains and losses that alter the dosage of hundreds of genes at once.

Lippman's team dug deeper into the tomato genome and found a way to fine - tune the level of branching by lowering the dosages of certain genes.

By utilizing paired genome - wide high - throughput DNA sequencing (DNA - seq) with RNA - seq, we found that gene dosage, at the level of individual genes or chromosomal «somy» (a general term covering disomy, trisomy, tetrasomy, etc.), accounted for greater than 85 % of total gene expression variation in genes with a 2-fold or greater change in expression.

Our results suggest that gene dosage is an adaptive trait that confers phenotypic plasticity among natural Leishmania populations by rapid down - or upregulation of transporter proteins to limit the effects of environmental stresses, such as drug selection.

Like Page's group, the Swiss team also found that Y chromosome genes were expressed in a variety of tissues beyond those involved in sexual development and are dosage - dependent.

Leishmania lacks classical regulation of transcription at initiation through promoters, so aneuploidy could represent a major adaptive strategy of this parasite to modulate gene dosage in response to stressful environments.

A ClinGen curated resource of genes and regions of the genome that are dosage sensitive and should be targeted on a cytogenomic array.

Here we will use it to seek evidence for an increased dependence of protein function on gene dosage upon aging.