Sentences with phrase «of gene expression by»

More recent research on the epigenetic modification of gene expression by early maternal care in animals suggests the possibility of similar processes affecting human development.

Intracellular uptake and inhibition of gene expression by PNAs and PNA - peptide conjugates.

His lab is interested in the regulation of gene expression by mRNA processing in C. elegans and human cells.

EPFL biologists and geneticists have uncovered how the circadian clock orchestrates the 24 - hour cycle of gene expression by regulating the structure of chromatin, the tightly wound DNA - protein complex of the cell.

Not exact matches

Taylor and colleagues made this discovery by exposing fetal mice to BPA during pregnancy and examining gene expression and DNA in the uteruses of female fetuses.

Results showed that BPA exposure permanently affected the uterus by decreasing regulation of gene expression.

The resulting transcriptional profiles cluster not by postpartum day, but by milk Na: K ratio, indicating that women sampled during similar postpartum time frames could be at markedly different stages of gene expression.

The shared patterns of gene expression in the limbs and phallus are generated in part by a common set of noncoding DNA, also called «elements» or «enhancers,» which act to control gene expression in both of these structures, argues a study published October 1 in Developmental Cell.

Scientists at Southern Methodist University, led by Professor and Chair of Biological Sciences Santosh D'Mello, have used RNA - Seq to conduct transcriptome profiling of gene expression changes in dying neurons.

In the new research, the UB scientists found they could reverse those social deficits with a very low dose of romidepsin, which, they found, restores gene expression and function using an epigenetic mechanism, where gene changes are caused by influences other than DNA sequences.

An international team led by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a new technique for identifying gene enhancers — sequences of DNA that act to amplify the expression of a specific gene — in the genomes of humans and other mammals.

«Autism's social deficits are reversed by an anti-cancer drug: Using an epigenetic mechanism, romidepsin restored gene expression and alleviated social deficits in animal models of autism.»

A protein called peroxisome proliferator — activated receptor g co-activator 1 - alpha (PGC1 - alpha) regulates the expression of many genes identified by the researchers.

Volatile release stimulated by volicitin may also depend on the octadecanoid pathway, raising the possibility of cross talk between this molecule and the wound - induced expression of defense genes.

A team of researchers from BWH has tackled this problem by comprehensively analyzing gene expression and protein distribution in human aortic valves obtained from valve replacement surgery.

Messenger RNA (mRNA) serves as an important intermediary during gene expression, by relating the genetic information of DNA to the molecular mechanisms involved in manufacturing proteins.

A single miRNA can ramp down expression of multiple genes — but the number of genes affected by known miRNAs hasn't been determined.

This image shows the metabolic expression of a gene identified by scientists from EPFL in Lausanne and ETH Zürich as being a key player in the development of type 2 diabetes.

By identifying gene expression signatures common to sight, touch and hearing, neuroscientists at the University of Geneva (UNIGE), Switzerland, discovered a sensory «lingua franca» which facilitates the brain's interpretation and integration of sensory input.

A team of scientists led by the University of Birmingham has shown how a common mRNA modification, N6 - methyladenosine (m6A), regulates gene expression to determine the sex of fruit flies.

The overlap in gene expression changes when neural progenitor cells are infected by African or Asian strains of Zika virus.

RNAScope ISH was developed by Advanced Cell Diagnostics (ACD) Inc., initially for studies of gene expression in animal (and especially human) tissues.

By blocking the expression of a certain gene in patients, University of Montreal researchers have contributed to the demonstration of great decreases in the concentration of triglycerides in their blood, even in various severe forms of hypertriglyceridemia and regardless of the base values or the treatment the patient usually receives.

Among the historical figures bound by the thematic thread of dna in journalist Sam Kean's new book are Charles Hapsburg, whose weak chin was the result of royal inbreeding, and a group of Arctic explorers who were poisoned by the Vitamin A in polar bear liver, which threw off their gene expression.

The two - step process of TILT — getting sick upon toxicant exposure and failing to get well — may be driven by epigenetic changes, which occur when the environment alters the expression of genes without changing the core DNA code itself.

By tracking activity in almost all the genes of a free - living archaeon — which, like a bacterium, is a prokaryote — Bonneau was recently able to piece together how the genes affected one another's expression, enabling him to map the organism's «control circuit» as if it were a machine.

The direct methylation of the DNA changes the gene expression permanently if it takes place in the control regions of genes (so - called CpG islands), that have been made accessible by the modification of the histones.

In a new study published in Physiological Genomics, a team of U.S. researchers tracked in detail how this extreme makeover is controlled by changes in gene expression.

By day 34 of development, however, the pattern of gene expression was much more similar to control cows derived from artificial insemination, suggesting that these surviving clones were able to implant in the uterus and begin to form a placenta.

This means that gene expression can be measured by the amount of each unique type of mRNA found in a blood sample.

The Epstein - Barr virus, which infects some 90 % of Americans, may cause changes in gene expression that dramatically increase a person's chance of getting lupus and six other autoimmune disorders, a new study by Harley, now a rheumatologist at the Cincinnati Children's Hospital Medical Center in Ohio, and colleagues shows.

Four days later, the livers of the non-supressed mice had readjusted to a normal daily rhythm, as revealed by the daily rise and fall of liver - gene expression.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

Sure enough, plant root cells that harbor fungal arbuscules increase their expression of genes involved in producing such lipids by 3000-fold.

They did this by testing tissue concentrations of fatty acids in liver, muscle and brain tissue, along with the expression of genes involved in regulating EPA status and its physiological benefits.

«This could mean that the reversal or suppression of pathological gene expression by beta blockers is somehow protective against heart failure, but it's something we would need to look into further to understand how individual genes function in the heart.»

«It is exciting to find a correlation between brain circuitry and gene expression by combining high quality data from these two large - scale projects,» says David Van Essen, Ph.D., professor at Washington University in St. Louis and a leader of the Human Connectome Project.

W: We should have gene expression and big projects organized by the National Institutes of Health, and they're not doing anything.

Despite the anatomical complexity of the brain and the complexity of the human genome, most of the patterns of gene usage across all 20,000 genes could be characterized by just 32 expression patterns.

Then they compared the expression of thousands of genes in two samples by measuring levels of messenger RNA.

An antisense - based treatment called nusinersen, which removes a roadblock in the expression of the second SMN gene, was recently approved by the FDA.

By examining gene expression patterns, the new study found that parrot brains are structured differently than the brains of songbirds and hummingbirds, which also exhibit vocal learning.

Investigators at Duke University, led by Erica Davis, PhD, a co-senior author of the report, blocked the gene's expression in zebrafish, which resulted in abnormal facial cartilage, smaller eyes and structural abnormalities of neurons involved in the development of reproductive organs.

FA is caused by reduced expression of a mitochondrial protein called frataxin (FXN) due to a two mutated or abnormal copies of the FXN gene.

«The number of protein functions that are currently targeted by drugs is incredibly small compared to the total number of protein interactions that could be targeted for therapeutic benefit,» says Geoffrey Wahl, a professor in Salk's Gene Expression Laboratory.

A decade of post-genomic biology has also focused new attention on the regions outside protein - coding genes, many of which are likely to have key functions, through regulating the expression of protein - coding genes and by making a slew of non-coding RNA molecules.

A new study from the Institute of Food Research has uncovered a mechanism by which Salmonella bacteria organise the expression of genes required for infection.

Another version, the CTC - iChip, rapidly isolates CTCs in a way that does not rely on preidentified tumor antigens, allowing capture of cells with gene expression patterns that may be missed by the antibodies used in the HBCTC - Chip.

The once - disparate fields of psychiatry and molecular genetics have been merged by physician - scientists who study the correlation between gene expression, transcription, and human behaviors.

It's not clear, for example, if the process of analyzing gene expression from a tumor biopsy to decide on a course of treatment can be protected by a patent.