Sentences with phrase «of gene function»

The institute will combine under one roof the various kinds of expertise needed to perform studies of gene function on a large scale.

The group also develops new compounds targeting the epigenetic regulation of gene function.

We are pleased to contribute to this international effort establishing a global resource of knockout mice and related database of gene function.

The CNCR focuses on the mechanistic understanding of gene function in the context of cognitive function.

Howard Hughes Medical Institute scientists have developed a much - needed genetic resource that will greatly accelerate the study of gene functions in wheat.

To address this challenge, the International Mouse Phenotyping Consortium (IMPC) is creating a genome - and phenome - wide catalogue of gene function by characterizing new knockout - mouse strains across diverse biological systems through a broad set of standardized phenotyping tests.

Researchers, funded by Cancer Research UK, from the Section of Gene Function and Regulation and the Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research (ICR), have pinpointed early genetic changes that lead to cancer in mice lacking the BRCA2 gene in their prostate gland.

«Although the medical applications utilizing light regulated gene expression are in the distant future, the first applications will be probably found among life science basic research areas which are in the need of accurate control of gene function» Dr. Rossi says.

Optogenetic methods and tools have evolved fast, and in addition to be able to control cellular activity, researchers can now control the activity of gene function.

He said future directions for the study included pinpointing the exact types of gene functions involved and to understanding the broader consequences of male - female interactions and their relevance to the evolutionary history of other species.

This allowed them to identify specific genes that are turned on or off by co-regulators of gene function called TAZ and YAP in the nucleus of developing mouse Schwann cells.

Much of this DNA is no longer capable of moving, but is likely «auditioning» perhaps as a regulator of gene function or in homologous recombination, which is a type of genetic recombination where the basic structural units of DNA, nucleotide sequences, are exchanged between two DNA molecules to repair breaks in the DNA strands.

Hence it is imperative to the health of an organism that both classes of genes function normally to maintain balance — encouraging cells to grow and divide only at the right times and in the right places.

11:15 - 12:15 PM Evaluation of mouse embryonic developmental defects as evidence of gene function Kelli Boyd, Vanderbilt University

The Phenotyping department provides comprehensive, standardized or advanced, customized characterization of gene function in mouse models.

Remarkable new tools, made possible by dCas9, are coming to fruition that will allow for a new kind of interrogation of gene function, allowing us to ask more sophisticated questions about the biology of drug targets.

«Vertical integration of gene function» describes how gene expression initiates a series of biochemical, cellular, and physiological changes that ultimately culminate in an observable behavior.

Mi, H., Muruganujan, A. & Thomas, P.D. PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees.

I am particularly pleased that the fundamental knowledge of gene function and the derivation of animal models of human disease are underpinning important therapeutic advances.

Finally, animal research focusing on brain - structural aspects related to early care and the new, conceptually important direction of studying environmental programming of early development through epigenetic modification of gene functioning is examined in brief.

In these diseases, the NMD pathway eliminates the RNA, resulting in a complete loss of the gene function.

«The collaboration of scientists with computational skills, others with population genetics and large - scale genomics knowledge, and those with in - depth understanding of gene function and interaction from the molecular to the whole - tree level is a major step forward,» she said.

The advent of genomics and rapid sequencing techniques has seen HeLa cells used in numerous large - scale studies of gene function and expression.

INFRAFRONTIER aims to build a world - class research infrastructure that provides the biomedical research community with the tools needed to unravel the role of gene function...

Lead author, Dr Amanda Swain, from the Section of Gene Function and Regulation at the ICR, said: «The discovery that BRCA2 alterations play the same role in the development of hereditary prostate cancer as they do in breast cancer is an important step.

After inserting more than 400 human genes into yeast cells one at a time, researchers found that almost 50 % of the genes functioned and enabled the fungi to survive.

Thus, most mutations resulting in loss of gene function are known as recessive, meaning that an organism must inherit two mutant copies of the gene from its parents before an overt defect is observed, as is the case in humans with muscular dystrophy, cystic fibrosis or Tay Sachs disease.

Announcing the award, the Nobel Assembly said of the three men's research: «Its impact on the understanding of gene function and its benefits to mankind will continue to increase over many years to come.»

Embryonic stem (ES) cells are important tools in the study of gene function and may also become important in cell therapy applications.

The goal is to produce a comprehensive «encyclopedia «of gene function, that will help identify causative factors of human diseases as well as novel targets for therapeutic intervention.

The wealth of Drosophila resources and knowledge make it a powerful tool for accelerating our understanding of gene function, and the authors encourage greater collaboration and communication between fly biologists, human geneticists, and clinicians.