Sentences with phrase «of gene loci»

From the genome wide scan, a set of gene loci correspond to thermostatic regulation has been identified.

Not exact matches

Simulating the yield impacts of organ - level quantitative trait loci associated with drought response in maize: A «gene - to - phenotype» modeling approach.

For example, in sporadic PD, multiple GWAS point to the alpha - synuclein gene (SNCA) as one of the strongest risk loci in patients» genomes, yet GWAS contain little information regarding the mechanism of how this gene is dysregulated in sporadic PD patients.

A major finding of this study is that the genetic loci associated with asthma are enriched in epigenetic marks characterizing gene enhancers.

By using engineered zinc - finger nucleases (ZFNs) designed to target an integrated reporter and two endogenous rat genes, Immunoglobulin M (IgM) and Rab38, we demonstrate that a single injection of DNA or messenger RNA encoding ZFNs into the one - cell rat embryo leads to a high frequency of animals carrying 25 to 100 % disruption at the target locus.

At the bottom is an extra line that includes the shorthand names of the 13 «CODIS loci,» the locations on a person's genes that are read to make a DNA profile.

In their study, the researchers showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other mice.

A locus is the position of a gene on a chromosome.

Although many different malaria resistance loci have been postulated over the years, this is one of very few that have stood up to stringent testing in a large multi-centre study; the others include the genes for sickle cell and the O blood group.

The new locus they have identified is near a cluster of genes which code for proteins called «glycophorins» that are involved in the malaria parasite's invasion of red blood cells.

The second locus significantly correlated with severe CCD was on chromosome 11, the same chromosome that contains a gene thought to increase the risk of schizophrenia in humans.

The investigators confirmed the activity of genes at the newly identified loci by probing discarded corneal tissue from deceased individuals with and without Fuchs.

Analyses found novel associations with three loci — regions of the genetic code — and the disorder at genes KANK4, LAMC1 and ATP1B1.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

Results from the analysis confirmed previous findings of some copy number variants already associated with autism, but they also found a host of other genes (SHANK2, SYNGAP1, DLGAP2 and the X chromosome — linked DDX53 - PTCHD1 locus) in which mutations seem to be linked to autism.

This essentially gives us «barcodes» of specific gene loci, which we can use to help untangle the complex genetics of complex diseases,» said Andrey Rzhetsky, PhD, professor of genetic medicine and human genetics at the University of Chicago, who led the study.

The exact site of the Odysseus (Ods) locus of hybrid male sterility inDrosophila contains such a homeobox gene.

The puffy appearance was a known sign that genes were being activated in those regions to give rise to their encoded proteins, so those sites of activity became known as the heat shock loci.

This cascade of activity enables PRC2 to spread this modification over the entire neighboring gene loci, thereby marking it for silencing.

Another one of the loci identified, SNCA, is also associated with Parkinson's, but differently — the researchers found that a different part of the gene is linked to DLB.

Not only do black - furred dogs and wolves have the same gene variant, but the DNA surrounding the K locus is also quite similar — and quite different from that of gray wolves — suggesting that the variant was introduced when wolves interbred with domestic dogs.

This interaction is explained by divergent evolution occurring among paralogs of an essential duplicate gene, for which the functional copy is not located at the same locus in different accessions.

Analyzing the DNA of about 3,500 diagnosed people and nearly 11,000 without the disorder, researchers homed in on a genetic locus — a gene's location on a chromosome — that's involved in the body's metabolic processes and seems to be associated with the disorder.

«As the gene loci that had previously been associated with DLB were also implicated in Alzheimer's and Parkinson's, it was unclear if DLB's genetic roots were simply a combination of the other two diseases.

These regions can be clumped into larger areas of the genome called quantitative trait loci, which are known to contain genes that produce a specific physical effect, such as shaggy hair.

Experts believe that the gene loci discovered to date explain at most 5 percent of problematic behaviors.

Scientifically, the success was the engineering of a gene cassette containing four genes for the micronutrient improvement that could be inserted into the rice genome as a single genetic locus.

But when we put these genetic associations alongside the ENCODE data, we saw that although the loci are not close to a protein - coding gene, they really are close to one of these new elements that we're discovering.

To demonstrate the critical role for ecRNA - directed methylation, first author Katherine Savell, a graduate student in the Day lab, blocked one specific ecRNA for the Fos gene locus in the hippocampus of the rat brain.

The researchers also provided a detailed analysis of ecRNAs arising from the Fos gene locus.

The more powerful one occurred within a stretch of DNA, or locus, that contains the HCP5 gene, which codes for a human endogenous retrovirus — a genetic fossil of a virus that wove itself into human chromosomes long ago but no longer produces infectious progeny.

«If we can identify similar genetic loci in people, and if we could find biomarkers for these gene - environment interactions, then perhaps we could develop a simple blood test that identifies people who are at high risk of cancer from low - dose radiation,» says Mao.

Mature miR - 7 is individually transcribed and processed from 3 different gene locus in human genome, and it is highly expressed in parts of the brain, eye, and pancreas, suggesting its role in the development of these organs (20 — 22).

It's therefore a thrill when there's an update to RetNet — the database of genes and loci causing retinal disease — that includes one of our recent discoveries.

Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in Virulence.

This is the case at the level of loci (e.g. identifying causal variants underlying genome - wide associations), genes (e.g. understanding not only that mutations in gene X underlie a given phenotype, but also the how and why of it), and variants (e.g. variants of uncertain significance).

Some ~ 20 % of loci examined exhibited cis - regulatory assocations between somatic CNAs and gene expression.

This locus contains a conserved non-coding element (CNE) upstream of three neuronal cell adhesion molecule (NCAM) genes, where the derived «sand» allele appears to disrupt a neuronal transcription factor binding motif.

Together, these integrated results suggest that evolution of gene expression at the NCAM locus has accompanied behavioral adaptation to microhabitat, which could ultimately reinforce speciation through spatial isolation.

The Mir 137 locus encodes a micro RNA that regulated hundreds of other genes, and several of those are also linked to schizophrenia.

The locus sits close to an area of the genome where humans and chimps are known to share specific combinations of genes.

Further, his group pioneered expression quantitative trait locus (eQTL) studies, which enabled variation in global gene expression to be applied to genetics of complex human diseases.

Other accomplishments in this area include the mapping of variation in the FTO gene for obesity, characterizing the role of interleukin (IL)-6, IL - 10, and IL - 1RA in obesity and insulin resistance in African Americans (AA), and determining the loci associated with CRP, IL - 10, IL - 1Ra, and IL - 6 levels in a GWAS of AA.

Multiple transcripts arising from alternative initiation or polyadenylation sites, or alternative RNA splicing at a single locus were not considered as multiple genes but as variants of a single transcription unit.

From this large sample comprising a quarter of the fly genome we estimate that there are approximately 3600 lethal loci in a Drosophila genome of 12,000 genes (Table 2).

Citation: George is credited with the cloning of many novel kallikrein and other genes, the characterization of the kallikrein locus and the demonstration that many of these genes are regulated by steroid hormones and can act as effective cancer biomarkers.

Disrupting «Silent» Genes The number of transcripts appears to exceed the number of mutable loci in several extensively analyzed segments of the Drosophila genome (34 - 35).

Type I parasites are typically highly lethal in mice; however, the recent identification of ROP5 genes as the mediators of acute virulence and the generation of attenuated parasites lacking this locus [16], [17] permits long - term Type I infection studies in mice, perhaps due to a non-persistent infection following Immunity Related GTPase - mediated clearance.

Targeted Gene Addition to a Safe Harbor locus in human CD34 + Hematopoietic Stem Cells for Correction of X-linked Chronic Granulomatous Disease.

Our first striking observation was that over one half of measured genes are affected by common genetic variation in human populations — called expression quantitative trait loci or eQTLs.