Sentences with phrase «of gene pathways»

Two years into her research on a mouse - model study of a gene pathway's role in the immune system, she joined UCB Celltech.

Not exact matches

But there may be other, more deeply rooted, connections — tracing to an overlooked intersection of gene interactions or to another surprise crossing of molecular pathways.

Nurturing behaviors stimulate activation of pathways that remove methyl groups from DNA, allowing the glucocorticoid gene, which lowers stress response, to be activated.

Therefore, we questioned whether PTPRF gene expression might be elevated in Mature Group 2 samples, as PTPRF overexpression could be causing excessive downward modulation of the insulin signaling pathway in the women with lower insulin sensitivity.

Xie et al. report that STING (stimulator of interferon genes)-- the main adaptor in several DNA - sensing pathways — is mutated in bats at the serine - 358 residue, which is critical for downstream interferon (IFN) activation.

Volatile release stimulated by volicitin may also depend on the octadecanoid pathway, raising the possibility of cross talk between this molecule and the wound - induced expression of defense genes.

In all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent manner.

Susceptibility genes for diabetes may be involved in several different metabolic pathways in the body, including storage and release of fat for energy.

Huntington's monkeys also show levels of inflammatory markers (cytokines and inflammatory pathway genes) in their blood that is greater than in controls.

They specifically applied their model to the Ras pathway, a family of genes that make proteins that govern cell replication and death.

Chung and Felton then investigated expression of genes in the anti-herbivore pathway and the production of enzymes.

The Geneva neuroscientists» results thus reveal that during development, the various sensory pathways initially share a common gene expression structure, which then adapts to the activity of the organ attached to each sense.

Up to 15 percent of people's genes are regulated by the day - night pattern of circadian rhythms, including those involved with metabolic pathways in the liver.

Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

The cannabinoids inhibited the expression of several genes critical to angiogenesis known as the VEGF (vascular endothelial growth factor) pathway.

Fruit flies with the mutant form of LRRK2 also had a disrupted microRNA pathway associated with the gene, and accumulated toxic proteins that killed motor - coordinating neurons in the brain.

«The next step is to identify antibodies and small - molecule drugs that can successfully target Helios or genes in the Helios pathway,» says the study's lead author, Hye - Jung Kim, PhD, of Dana - Farber.

The study also found that some of the morphing genes in the python's intestine, notably those in a signaling pathway called WNT, were genes that were involved in intestinal and other cancers.

The team designed the Haploinsufficient / Triplosensitive Gene (HAPTRIG) computational tool to identify pathways significantly disrupted by the loss and gain of genes.

Cobbling together the genes of three different species, chemical engineer Jay Keasling (Discover's 2006 Scientist of the Year) of the University of California at Berkeley transformed a metabolic pathway in yeast that allows the engineered microbe to produce a precursor to artemisinin, a compound used to treat malaria.

The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast.

«We showed that the deletion of the gene responsible for this pathway can restore the original therapeutic function of the cells,» said Prof. Leor.

They have also used state - of - the - art information about brain development to accurately pinpoint new genes and biological pathways implicated in this disorder.

«Nature has already done the work of tuning genes and metabolic pathways to the environment of the organism.

Scientists from the Biogerontology Research Foundation (BGRF), a UK - based charity founded to support aging research and address the challenges of a rapidly aging population, propose a new concept for signalome - wide analysis of changes in intracellular pathways, called OncoFinder, which allows for accurate and robust cross-platform analysis of gene expression data.

And the mutation that bestows such remarkable longevity is a gene that happens to regulate activity in the insulin / IGF signaling pathway, says Robert Schmookler - Reis of the University of Arkansas, a molecular geneticist who discovered the relationship between the mutation and the superworm's extraordinary life.

The most «striking» find, Austad adds, is the role of a gene known as FOXO, which is regulated by the insulin / IGF pathway.

«RB loss causes a major reprogramming of gene expression, allowing induction of pathways that promote features that induce characteristics of lethal disease,» said senior author Karen Knudsen, PhD, Director of the Sidney Kimmel Cancer Center (SKCC) at Thomas Jefferson University.

Participants who lacked two genes involved in a genetic pathway that helps the antioxidant glutathione remove carcinogens and toxicants from the body saw an even bigger benefit to taking the watercress extract, which increased their detoxification of benzene by 95.4 percent, acrolein by 32.7 percent and crotonaldehyde by 29.8 percent.

«Our research has identified a gene affecting another type of ischemic stroke, due to small vessel disease, and also suggests some genes may be associated with both ischemic and hemorrhagic stroke and may act through a novel pathway affecting pericytes, a type of cell in the wall of small arteries and capillaries.

«However, recent work has shown that at least some of the fungal partners in arbuscular mycorrhizal symbioses lack the genes for enzymes involved in the major pathway of lipid biosynthesis, and are therefore unable to produce certain essential fatty acids,» Gutjahr explains.

Many of the genes identified by Dr. Papapanou and his team are implicated in immune and inflammatory pathways, confirming laboratory and clinical observations of the development of periodontal disease.

Other groups had already supplied yeast with genes for the second half of the pathway, which converts a similar intermediate called R - reticuline into codeine, morphine, and the like.

Interestingly, the let - 7 family of micro RNA affects several key genes that regulate glucose metabolism, called the PI3 / AKT / insulin pathway.»

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

Research led by Margery Smelkinson found that NS1 modulates the activitiy of a signaling cascade known as the Hedgehog pathway (so named because fruit fly larvae lacking the Hedgehog gene emerge hairless and resemble tiny hedgehogs).

They identified previously unknown recurrent loss - of - function mutations that target genes regulating epigenetic pathways — ones that act on how tightly or loosely chromosomes are wound and thus accessible for genes to be expressed.

We have some gene candidates for the next step of the pathway, and we are just starting to characterize those.»

The study was the first of its kind to employ genome - wide reverse engineering to identify the gene pathways that contribute to periodontitis.

Both findings suggest that different types of autism may share a common pathway even when they occur in distinct syndromes or alone — something that wasn't clear just from looking at the genes.

By combining salivary gene expression profiles, postconceptional age and sex, this predictive model not only assessed the probability of feeding success, but also, and most importantly, highlighted specific developmental pathways that were likely contributing to feeding immaturity.

They looked at other genes that interacted with TAK1 kinase including activators and inhibitors of the TAK1 pathway and found that most of them also affected regeneration, but only when worms were infected.

Dias and Ressler probed the Notch pathway because they were examining many genes that are activated in the brains of mice after they learn to become afraid of a sound paired with a mild foot - shock.

By mapping out the genes of this parasite, researchers aim to better understand its molecular pathways.

Understanding the role of the microbes that live in the gut and help process nutrients not only promises a fuller understanding of the link between genes, diet and disease, but may also be a pathway to pinpointing the genes responsible for conditions like diabetes.

Nucleic acid and protein sequences, as well as three - dimensional structures of proteins, are frequently the objects of study, but gene expression as well as the simulation of pathways and biochemical networks are attracting more and more attention.

But BRCA is just one of the many genes that encode important proteins in the DNA repair pathway known as homologous recombination,» says the study's lead author, Arielle Heeke, MD, a clinical fellow at Georgetown Lombardi Comprehensive Cancer Center.

The gene expression similarities between this common condition and the current findings in late - stage RP suggest that the canine RP models could serve as stand - ins to evaluate the effectiveness of pharmaceutical interventions that target innate immunity pathways in AMD

On the flip side, turning up expression of these genes or their pathways could help researchers grow new intestinal tissue to replace tissue destroyed by diseases such as inflammatory bowel disease or radiation treatment for cancer.