Sentences with phrase «of gene regions»

Not exact matches

That's not to say gene editing is new (it isn't), but Crispr simplifies the process by using molecular scissors that can be precisely targeted to snip out aberrant regions of genetic code, which can then be replaced with the correct sequences.

I spent a year researching a 96 basepair region of the non-coding region of a gene in an attempt to demonstrate its supposed enhancer properties on that gene.

We've developed a range of tools and techniques to answer today's challenges and plan for the future, including gene technology, digital modelling and region - specific strategies.

The researches found that the transgene was inserted into an active region of the genome, thereby disrupting the coding sequence and ultimately the function of the plants own OsAux1 gene.

The reliability and stability of these methods were described by Wu et al. 27 Illumina tag sequencing of the 16S rRNA gene V4 - V5 hypervariable region was performed at the Marine Biological Laboratory in Woods Hole, Massachusetts, using established methods.28, 29 Details of sequencing methods, quality control and filtering, and statistical modeling are presented in the eAppendix in the Supplement.

The researchers then found that these same genes carry an additional risk for a phenomenon called spreading depolarization, a slowly - progressing, temporary electrical blackout of a region in the brain.

This permits high - resolution mapping of genes and chromosomal regions on single fibers of DNA, and it targets the physical location of mitochondrial DNA probes down to a resolution of 1,000 base pairs.

«Manyfold more genes were regulated in the resilient animals than in the susceptible animals across several brain regions,» says Eric Nestler, director of The Friedman Brain Institute at Icahn School of Medicine at Mount Sinai.

McCallion's strategy to make sense of all this data looks at the active genes in cells affected by a disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for disease risk down to just a handful within any one implicated region.

People who inherit a mutated version of the ATF6 gene are born with a malformed or missing fovea, the eye region responsible for sharp, detailed vision.

He also suggested that «there is a connection» between Bt cotton, a GM product that includes genes from Bacillus thuringiensis (Bt) to make it pest - resistant, and farmers» suicides, referring to thousands of farmers who have committed suicide in the last few years due to indebtedness, mostly in cotton growing regions.

In a three - stage meta - analysis, Harvard University neurologist Clemens Scherzer and his collaborators analyzed gene expression in 410 samples taken from patients that either had symptomatic or asymptomatic Parkinson's or were healthy, including 185 samples of substantia nigra — a midbrain region where dopamine neurons are particularly susceptible to degeneration.

Of the genes involved in Parkinson's disease that are present in indicated regions, the strategy captured all but one.

While they don't have definite answers, besides having good genes, Kawas said, the answer is probably a combination of being resilient to Alzheimer's Disease and also that they did not develop other dementia - causing conditions, such as microscopic infarctions that occur when blood flow is blocked from certain regions of the brain and hippocampal sclerosis, which causes neuron loss.

By using the strategy, he and his team were able to filter down the thousands of genes in these sections to an average of two per region.

GWAS identify regions of the genome that can contain hundreds of genes potentially affected by a mutation.

The SRY (sex - determining region Y) gene on the male's Y chromosome orchestrates the formation of the testes, while the gonadal precursor will differentiate into an ovary by default (in the absence of the steroids produced by the testes).

This region of homologous is encoded by eight contiguous exons in each respective gene.

However, the team also found virulence genes in regions of the genome that are not so variable.

The tests especially differ in that they examine different regions of the viral gene.

Conventional wisdom has it that genes vital to the life or reproduction of a cell are likely to be highly conserved, yet these crucial regions appear to be diverging rapidly.

Gene discovery was greatly facilitated by a new exome sequencing technology, which analyzes all protein - coding regions of the genome at once.

The authors defined the gene signature of the different regions surrounding the wound to uncover the gene expression signature of the cells that actively divide and those that migrate to repair the wound.

The researchers then examined a number of DNA variants in the protein production - control region of the bellwether gene in cell cultures.

This finding suggests that the homologous region may have resulted from a duplication of an ancestral gene and that the two genes evolved further by recruitment of exons from other genes, which provided the specific functional domains of the LDL receptor and the EGF precursor.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

Comparisons of the Neandertal genome to the genomes of five present - day humans from different parts of the world identify a number of genomic regions that may have been affected by positive selection in ancestral modern humans, including genes involved in metabolism and in cognitive and skeletal development.

Viral - mediated gene transfer now enables investigators to overexpress or knock out a gene of interest within highly localized regions of brain.

This consortium selected 44 separate sections of the genome that included regions of high to low gene density and high to low similarity between mouse and human.

The direct methylation of the DNA changes the gene expression permanently if it takes place in the control regions of genes (so - called CpG islands), that have been made accessible by the modification of the histones.

«The interesting thing is that when we looked the same dog genes in human breast cancer, epigenetic aberrations occur in the same regions of DNA.

One of these regions includes the site of the FOXP2 «language» gene.

«The IMM teams showed clearly that the gene was switched on only in hypoxic regions,» says Sue Kingsman, the research director of Oxford BioMedica.

They add that other genes in the region of the genome around Gp - 9 are probably involved in regulating fire ant social organization as well.

The result is that individuals with the most common form of the disease have a total of three copies of all the genes in this region.

Finally, the team identified a network of genes in these regions that exhibit changes in expression when the normal boost from serotonin is lacking, and these changes depended on how long the drug was given.

Further molecular biological studies by the scientists demonstrated that methylation in the non-coding region of the Igfbp2 gene contributes to less IGFBP2 synthesis.

The key differences they uncovered lay within regions of the gene that regulate how many receptors are made.

We did not find any evidence for a so - called «positive selection» but instead found that many gene variants linked to schizophrenia reside in regions of the genome in which natural selection is not very effective in the first place.

If it is true that epigenetic changes to genes active in certain regions of the brain underlie our emotional and intellectual intelligence — our tendency to be calm or fearful, our ability to learn or to forget — then the question arises: Why can't we just take a drug to rinse away the unwanted methyl groups like a bar of epigenetic Irish Spring?

She speculates that the culprit may be a mutation located in a genome region that regulates activity of the IL - 33 gene.

«Genetics researchers close in on schizophrenia: 50 new gene regions that increase risk of developing schizophrenia.»

They lie in a region of chromosome 5 that sits squarely between two genes that produce cell - adhesion molecules, which govern how neurons connect to each other.

«By either skipping a mutation region or precisely repairing a mutation in the gene, CRISPR - Cpf1 - mediated genome editing not only corrects Duchenne muscular dystrophy mutations but also improves muscle contractility and strength,» said co-author Dr. Rhonda Bassel - Duby, Professor of Molecular Biology and Associate Director of the Hamon Center for Regenerative Science and Medicine.

Much like the association between BRCA gene mutation and the risk for breast cancer in women changed the approach to treatment / prevention, the identification of the Kallikrein 6 gene region may change the course of prostate cancer care through a blood test developed by the Lunenfeld - Tanenbaum Research Institute.

When oxygen is scarce, however, HIF - 1α starts to accumulate and turns on the expression of a host of genes that assist in promoting and increasing oxygen delivery to hypoxic regions.

The pilot project tested a dozen or so of the most commonly used gene promoters (regions of DNA that facilitate gene transcription) and segments of DNA that encode ribosome - binding sites (sequences of messenger RNA that control protein translation) to determine whether they behave consistently in different cellular contexts.

A decade of post-genomic biology has also focused new attention on the regions outside protein - coding genes, many of which are likely to have key functions, through regulating the expression of protein - coding genes and by making a slew of non-coding RNA molecules.

Of the nearly 7,000 genes in the mycobacterial genome, one region spanning just 6 genes appears to be key in determining whether a mycobacterial strain will be a donor or recipient when it comes to mating.

But in a closer study of 73 families researchers found a region of genes on chromosome eight in those with perfect pitch and from European ancestry.